Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David C. Zimmermann"'
Autor:
Michael A. Mauragis, Robert B. Appell, Theresa M. Schwartz, Lee S. Banitt, Paul J. Dobrowolski, John R. Palmer, Daugs Edward D, and Robert C. Clouse, Michael F. Lipton, Gordon L. Bundy, Michael F. Veley, David C. Zimmermann
Publikováno v:
Organic Process Research & Development. 5:144-151
Two syntheses are described for 1-[(2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indol-9-yl)-acetyl]pyrrolidine hydrochloride (PNU-142731A), a clinical candidate in the asthma area. The route involving the initial regioselective addition of glycine ethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc21c18fe7f1e5b862d2dc6692e84b0
https://doi.org/10.1021/op000221p
https://doi.org/10.1021/op000221p
Autor:
Larry T. Bell, Edward W. Thomas, Ronald H. Rynbrandt, Christine R. Muchmore, David C. Zimmermann, Ernest W. Yankee
Publikováno v:
ChemInform. 21
The reduction of pyrrolizidinediones with (i-Bu) 2 AlH and LiBHEt 3 affords the corresponding hexahydro-5-hydroxy-3H-pyrrolizin-3-ones in good yield. LiBHEt 3 also reduces N-methylglutarimide. The combination of NaBH 4 /MeOH/Ac 2 O/CH 2 Cl 2 selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b299478d912cb09ae1629730880b98
https://doi.org/10.1002/chin.199008145
https://doi.org/10.1002/chin.199008145
Publikováno v:
Journal of Medicinal Chemistry. 32:228-236
Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1,1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino) (4-morpholinyl) methyl]urea] (1) was active and represented the first example of a bis(ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d00e8ca450487b5dc1d1ca2f5ee2cf5
https://doi.org/10.1021/jm00121a041
https://doi.org/10.1021/jm00121a041
Autor:
Edward W. Thomas, David C. Zimmermann
Publikováno v:
Synthesis. 1985:945-948
Reactions de lithiation de phenyl-5 thiadiazole-1,2,3 en position 4 et de phenyl-4 thiadiazole-1,2,3 en position 5 suivies de reactions avec divers electrophiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e0ee60daaa0699db6566434e5e59729
https://doi.org/10.1055/s-1985-31395
https://doi.org/10.1055/s-1985-31395
Autor:
David C. Zimmermann, Christine R. Muchmore, Edward W. Thomas, Ronald H. Rynbrandt, Larry T. Bell, Ernest W. Yankee
Publikováno v:
The Journal of Organic Chemistry. 54:4535-4543
The reduction of pyrrolizidinediones with (i-Bu) 2 AlH and LiBHEt 3 affords the corresponding hexahydro-5-hydroxy-3H-pyrrolizin-3-ones in good yield. LiBHEt 3 also reduces N-methylglutarimide. The combination of NaBH 4 /MeOH/Ac 2 O/CH 2 Cl 2 selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7ed323723c5ae6051a0223ed679220
https://doi.org/10.1021/jo00280a018
https://doi.org/10.1021/jo00280a018
Publikováno v:
Journal of medicinal chemistry. 28(4)
Routine screening of compounds for inhibition of collagen-induced platelet aggregation in vitro revealed 4,5-bis-(4-methoxyphenyl)-1,2,3-thiadiazole (2) was active and it represents the first example of a 1,2,3-thiadiazole with possible antithromboti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ca5f5f46de7a82a5c9bef4f83201ab
https://pubmed.ncbi.nlm.nih.gov/3981535
https://pubmed.ncbi.nlm.nih.gov/3981535
Publikováno v:
Chemischer Informationsdienst. 16
Routine screening of compounds for inhibition of collagen-induced platelet aggregation in vitro revealed 4,5-bis-(4-methoxyphenyl)-1,2,3-thiadiazole (2) was active and it represents the first example of a 1,2,3-thiadiazole with possible antithromboti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69ff39fce5ba1bc4dda1a9dc2860e333
https://doi.org/10.1002/chin.198531217
https://doi.org/10.1002/chin.198531217
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