Zobrazeno 1 - 10
of 1 068
pro vyhledávání: '"David C. Whitcomb"'
Autor:
David C. Whitcomb, Sinead N. Duggan, Robert Martindale, Mark Lowe, Virginia A. Stallings, Darwin Conwell, Jodie A. Barkin, Georgios I. Papachristou, Sohail Z. Husain, Christopher E. Forsmark, Vivek Kaul
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 395-411 (2023)
Exocrine pancreatic insufficiency (EPI) is a clinically defined syndrome based on the physician’s assessment of a patient’s maldigestion. However, current clinical definitions are inadequate in determining (1) the threshold of reduced pancreatic
Externí odkaz:
https://doaj.org/article/b661e80b2dde44348d3261b79fd25db8
Autor:
Christian Bime, Nancy G. Casanova, Sara M. Camp, Radu C. Oita, Juliet Ndukum, Vivian Reyes Hernon, Dong Kyu Oh, Yansong Li, Phil J. Greer, David C. Whitcomb, Georgios I. Papachristou, Joe G. N. Garcia
Publikováno v:
BMC Anesthesiology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT) exhibits dual functionality – as an intracellular enzyme regulating nicotinamide adenine dinucleotide metabolism and as an extracellular secreted protein (eNAMPT) to function as a c
Externí odkaz:
https://doaj.org/article/4a9a6cb92cbb42b3867fe595c78e81c3
Autor:
David C. Whitcomb
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Traditional approaches to understanding the origins of chronic pancreatitis (CP) and find treatments led to abysmal failure. Thus, no drugs now exists to meet this need. Outdated concepts of the etiopathogenesis of CP have been replaced with new insi
Externí odkaz:
https://doaj.org/article/81d324cffa974e37ad61cc7d32e4bde0
Autor:
David C. Whitcomb
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 2, Pp 281-282 (2023)
Externí odkaz:
https://doaj.org/article/8f0fe4f1efce4dfa840c914abb135810
Autor:
Yonjung Kim, Ikhyun Jun, Dong Hoon Shin, Jihoon G. Yoon, He Piao, Jinsei Jung, Hyun Woo Park, Mary Hongying Cheng, Ivet Bahar, David C. Whitcomb, Min Goo Lee
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 79-103 (2020)
Backgraoud & Aims: Aberrant epithelial bicarbonate (HCO3−) secretion caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with several diseases including cystic fibrosis and pancreatitis. Dynamica
Externí odkaz:
https://doaj.org/article/c6eb1ab64573444889221934c2ae218e
Autor:
Pranav Murthy, Aatur D. Singhi, Mark A. Ross, Patricia Loughran, Pedram Paragomi, Georgios I. Papachristou, David C. Whitcomb, Amer H. Zureikat, Michael T. Lotze, Herbert J. Zeh III, Brian A. Boone
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic i
Externí odkaz:
https://doaj.org/article/2f246b1f618e4df2a01e34b810a99c8b
Autor:
David T. Chao, Nilesh H. Shah, Herbert J. Zeh, Aatur D. Singhi, Nathan Bahary, Kevin M. McGrath, Kenneth E. Fasanella, Amer H. Zureikat, David C. Whitcomb, Randall E. Brand
Publikováno v:
Gastroenterology Research and Practice, Vol 2018 (2018)
Background. Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at
Externí odkaz:
https://doaj.org/article/e7071c46e6964b80ae8b5771e7bddb2c
Autor:
Simon Sherman, Oleg Shats, Marsha A. Ketcham, Michelle A. Anderson, David C. Whitcomb, Henry T. Lynch, Paola Ghiorzo, Wendy S. Rubinstein, Aaron R. Sasson, William E. Grizzle, Gleb Haynatzki, Jianmin Feng, Alexander Sherman, Leo Kinarsky, Randall E. Brand
Publikováno v:
Cancer Informatics, Vol 2011, Iss 10, Pp 83-91 (2011)
Externí odkaz:
https://doaj.org/article/7596bc9ed3af4570a87ee7f4aa2e0d7f
Autor:
Robert S. Rosenson, Daniel Gaudet, Christie M. Ballantyne, Seth J. Baum, Jean Bergeron, Erin E. Kershaw, Patrick M. Moriarty, Paolo Rubba, David C. Whitcomb, Poulabi Banerjee, Andrew Gewitz, Claudia Gonzaga-Jauregui, Jennifer McGinniss, Manish P. Ponda, Robert Pordy, Jian Zhao, Daniel J. Rader
Publikováno v:
Nature Medicine. 29:729-737
Severe hypertriglyceridemia (sHTG) is an established risk factor for acute pancreatitis. Current therapeutic approaches for sHTG are often insufficient to reduce triglycerides and prevent acute pancreatitis. This phase 2 trial (NCT03452228) evaluated
Autor:
Phil A. Hart, Dana K. Andersen, Erica Lyons, Gregory A. Cote, Zobeida Cruz-Monserrate, Robert H. Dworkin, B. Joseph Elmunzer, Evan L. Fogel, Christopher E. Forsmark, Ian Gilron, Megan Golden, Aysegul Gozu, Lindsay McNair, Stephen J. Pandol, Emily R. Perito, Anna Evans Phillips, Jennifer A. Rabbitts, David C. Whitcomb, John A. Windsor, Dhiraj Yadav, Tonya M. Palermo
Publikováno v:
Pancreas. 51(7)
Recurrent acute pancreatitis and chronic pancreatitis represent high morbidity diseases, which are frequently associated with chronic abdominal pain, pancreatic insufficiencies, and reduced quality of life. Currently, there are no therapies to revers