Zobrazeno 1 - 10
of 457
pro vyhledávání: '"David C. Warltier"'
Autor:
Yanan Liu, Shelley L. Baumgardt, Juan Fang, Yang Shi, Shigang Qiao, Zeljko J. Bosnjak, Jeannette Vásquez-Vivar, Zhengyuan Xia, David C. Warltier, Judy R. Kersten, Zhi-Dong Ge
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic.
Externí odkaz:
https://doaj.org/article/10546a57160b4846a85f06d91c1197c8
Autor:
Thorsten M Leucker, Zhi-Dong Ge, Jesse Procknow, Yanan Liu, Yang Shi, Martin Bienengraeber, David C Warltier, Judy R Kersten
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70088 (2013)
Endothelial-myocardial interactions may be critically important for ischemia/reperfusion injury. Tetrahydrobiopterin (BH4) is a required cofactor for nitric oxide (NO) production by endothelial NO synthase (eNOS). Hyperglycemia (HG) leads to signific
Externí odkaz:
https://doaj.org/article/2c12d953f25c46dfa5868db72b12b888
Autor:
Zhi-Dong Ge, David C. Warltier, Zhengyuan Xia, Yanan Liu, Shigang Qiao, Shelley L. Baumgardt, Judy R. Kersten, Juan Fang, Yang Shi, Jeannette Vasquez-Vivar, Zeljko J. Bosnjak
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866a5d036ee608a06a30b01696574259
http://hdl.handle.net/10722/249606
http://hdl.handle.net/10722/249606
Publikováno v:
Journal of Molecular and Cellular Cardiology. 62:36-42
Nitric oxide (NO) is a crucial mediator of hindlimb collateralization and angiogenesis. Within tissues there are nitrosyl-heme proteins which have the potential to generate NO under conditions of hypoxia or low pH. Low level irradiation of blood and
Autor:
David C. Warltier, Dorothee Weihrauch, Adrian Coon, Zhi-Dong Ge, Judy R. Kersten, Ines Baotic, Filip Sedlic
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H219-H227
Acute hyperglycemia (AHG) decreases the availability of nitric oxide (NO) and impairs anesthetic preconditioning (APC)-elicited protection against myocardial infarction. We investigated whether D-4F, an apolipoprotein A-1 mimetic, rescues the myocard
Autor:
Shelley L. Baumgardt, David C. Warltier, Zhi-Dong Ge, Jianhai Du, Shigang Qiao, Yanan Liu, Juan Fang, Zeljko J. Bosnjak, Judy R. Kersten, Hsiang En Wu, Yang Shi, Mark Paterson
Publikováno v:
Scientific Reports
Diabetic cardiomyopathy increases the risk of heart failure and death. At present, there are no effective approaches to preventing its development in the clinic. Here we report that reduction of cardiac GTP cyclohydrolase 1 (GCH1) degradation by gene
Autor:
Juan Fang, David X. Zhang, Judy R. Kersten, Zeljko J. Bosnjak, Zhi-Dong Ge, Thorsten M. Leucker, Mark Paterson, David C. Warltier, Shelley L. Baumgardt
Publikováno v:
Circulation. Heart failure. 9(1)
Background— Diabetic heart disease is associated with tetrahydrobiopterin oxidation and high arginase activity, leading to endothelial nitric oxide synthase dysfunction. Sepiapterin (SEP) is a tetrahydrobiopterin precursor, and l -citrulline ( l -C
Autor:
David C. Warltier, Ines Baotic, Maria Muravyeva, Martin Bienengraeber, Anna K. Brzezinska, Thorsten M. Leucker, Judy R. Kersten, Dorothee Weihrauch, Phillip F. Pratt
Publikováno v:
Journal of Molecular and Cellular Cardiology. 51:803-811
Endothelial cells (EC) serve a paracrine function to enhance signaling in cardiomyocytes (CM), and conversely, CM secrete factors that impact EC function. Understanding how EC interact with CM may be critically important in the context of ischemia-re
Autor:
Jianhai Du, Zhi-Dong Ge, David C. Warltier, Anna K. Brzezinska, Thorsten M. Leucker, Nikolina Vladic, Phillip F. Pratt, Yang Shi, Judy R. Kersten
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H2130-H2139
Cardioprotection by ischemic preconditioning (IPC) is impaired during hyperglycemia, but the mechanisms underlying this phenomenon are poorly understood. This study investigated the role of hyperglycemia to adversely modulate tetrahydrobiopterin (BH4
Autor:
David C. Warltier, Martin Bienengraeber, Naoyuki Hirata, Yon Hee Shim, Dorothee Weihrauch, Judy R. Kersten, Philip F. Pratt, Zeljko J. Bosnjak, Nicole L. Lohr, Danijel Pravdic
Publikováno v:
Anesthesiology. 115:531-540
Background Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms of ROS generation remain unclear. In this study, the authors investigated if mitochondria-t