Zobrazeno 1 - 10
of 39
pro vyhledávání: '"David C. Tully"'
Autor:
Eloy D. Hernandez, Lianxing Zheng, Young Kim, Bin Fang, Bo Liu, Reginald A. Valdez, William F. Dietrich, Paul V. Rucker, Donatella Chianelli, James Schmeits, Dingjiu Bao, Jocelyn Zoll, Claire Dubois, Glenn C. Federe, Lihao Chen, Sean B. Joseph, Lloyd B. Klickstein, John Walker, Valentina Molteni, Peter McNamara, Shelly Meeusen, David C. Tully, Michael K. Badman, Jie Xu, Bryan Laffitte
Publikováno v:
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist obeticholic acid (OCA) has shown promise in a phase 2 study in patients
Externí odkaz:
https://doaj.org/article/f910e104a218414a82b33320fcf44859
Autor:
Ruhma Syeda, Jie Xu, Adrienne E Dubin, Bertrand Coste, Jayanti Mathur, Truc Huynh, Jason Matzen, Jianmin Lao, David C Tully, Ingo H Engels, H Michael Petrassi, Andrew M Schumacher, Mauricio Montal, Michael Bandell, Ardem Patapoutian
Publikováno v:
eLife, Vol 4 (2015)
Piezo ion channels are activated by various types of mechanical stimuli and function as biological pressure sensors in both vertebrates and invertebrates. To date, mechanical stimuli are the only means to activate Piezo ion channels and whether other
Externí odkaz:
https://doaj.org/article/20a3d73548454cefb9bd2e849079a1d3
Autor:
Sean B. Joseph, Paul Vincent Rucker, Peter McNamara, Michael Badman, Todd Groessl, Chianelli Donatella, Bo Liu, Alan Chu, Yugang Liu, Badry Bursulaya, H. Martin Seidel, Young Kim, John Nelson, Valentina Molteni, David C. Tully, David J Huang, Wendy Richmond, Andrew Phimister, Dingjiu Bao, Jane Wu, Thierry Schlama, Jason Roland, Eloy D. Hernandez, Bryan Laffitte, Jocelyn Zoll, Mahavir Prashad, Ignacio Sancho-Martinez, Robert Hill, Xiaodong Liu, James Schmeits
Publikováno v:
Journal of medicinal chemistry. 63(8)
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects on multiple aspects of the disease. FXR agonists reduce lipid accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308b3ff9affec6142819020e4a0d2b6c
https://pubmed.ncbi.nlm.nih.gov/31940200
https://pubmed.ncbi.nlm.nih.gov/31940200
Autor:
Peter McNamara, Jocelyn Zoll, Lianxing Zheng, Shelly Meeusen, Young Kim, Glenn C. Federe, Lihao Chen, Eloy D. Hernandez, John R. Walker, Dingjiu Bao, Lloyd B. Klickstein, William F. Dietrich, Paul Vincent Rucker, Valentina Molteni, Bin Fang, Reginald Valdez, Sean B. Joseph, Bo Liu, James Schmeits, Claire Dubois, Chianelli Donatella, Michael Badman, David C. Tully, Bryan Laffitte, Jie Xu
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist obeticholic acid (OCA) has shown promise in a phase 2 study in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b079294bba158fc56bd23ecf7f7afe6
https://pubmed.ncbi.nlm.nih.gov/31388629
https://pubmed.ncbi.nlm.nih.gov/31388629
Autor:
Xiaolei Ma, Gladys T. Muiru, Vincent H. J. Leonard, Yongjin Xu, Dirksen E. Bussiere, Weidong Zhong, Charles Wartchow, David C. Tully, Warne Robert L, Steven Shia, Kyoko Uehara, Alexey Rivkin, Isabel Zaror, Lili Xie, Dianna M. Baldwin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports
Scientific Reports
Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit. The result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676683a0bba30d0c344634542d5a6e86
https://doi.org/10.1038/s41598-017-09538-x
https://doi.org/10.1038/s41598-017-09538-x
Autor:
Chek Shik Lim, Advait Nagle, Chun Li, Clemens H. M. Kocken, Pranab Mishra, Tove Tuntland, Wei Lin Sandra Sim, Rachel Borboa, Case W. McNamara, Seh Yong Leong, Nobutaka Kato, Christophe Bodenreider, Anne-Marie Zeeman, Prasuna Guntapalli, Kelli Kuhen, Thomas Hollenbeck, Thierry T. Diagana, Arnab K. Chatterjee, Elizabeth A. Winzeler, Liying Jocelyn Tan, Jonathan Chang, Siti Nurdiana Abas, Paul W. Smith, Bryan K. S. Yeung, Yong Cheng Tan, David C. Tully, Jason Roland, Suresh B. Lakshminarayana, Bin Zou, Kerstin Gagaring
Publikováno v:
ACS Medicinal Chemistry Letters. 5:947-950
Imidazopyridine 1 was identified from a phenotypic screen against P. falciparum (Pf) blood stages and subsequently optimized for activity on liver-stage schizonts of the rodent parasite P. yoelii (Py) as well as hypnozoites of the simian parasite P.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d417d8d40c2968e0a864417b3499fd6
https://doi.org/10.1021/ml500244m
https://doi.org/10.1021/ml500244m
Autor:
Xuena Lin, Kelli Kuhen, Tao Wu, Elizabeth A. Winzeler, Christoph Fischli, Chun Li, Kerstin Gagaring, Jared Ek, Tiffany Chuan, Suresh B. Lakshminarayana, Rachel Borboa, Thomas Hollenbeck, Arnab K. Chatterjee, Fenghua Liu, Thierry T. Diagana, Richard Glynne, Caroline Francek, Reto Brun, Advait Nagle, John Isbell, Bo Liu, Christopher Caldwell, David C. Tully, David Plouffe, Tove Tuntland, Philip B. Alper, Suzanne Skolnik, Jonathan Chang, Jianling Wang, Matthias Rottmann, Zhong Chen
Publikováno v:
Journal of Medicinal Chemistry
On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial properties. These changes were carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67dd0822748c0b26acd0f3ad90e7ef8
https://doi.org/10.1021/jm300041e
https://doi.org/10.1021/jm300041e
Autor:
Jennifer L. Harris, David C. Tully, Michael Hornsby, Badry Bursulaya, Henry Danahay, Glen Spraggon, Aaron Shipway, Scott A. Lesley
Publikováno v:
Protein Science. 18:1081-1094
Prostasin or human channel-activating protease 1 has been reported to play a critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel. Here, the structure of the extracellular port
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b4a401514b40558ced1a69baa7d493
https://doi.org/10.1002/pro.118
https://doi.org/10.1002/pro.118
Autor:
Henry Danahay, Michael J. Roberts, Badry Bursulaya, H. Michael Petrassi, Vidal Agnes, Arnab K. Chatterjee, Jennifer A. Williams, Andrew M. Schumacher, David C. Tully, Aaron Shipway, Reynand Pacoma, Glen Spraggon, Jennifer L. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5895-5899
Structure-based design was utilized to guide the early stage optimization of a substrate-like inhibitor to afford potent peptidomimetic inhibitors of the channel-activating protease prostasin. The first X-ray crystal structures of prostasin with smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291bfb76c956b4360e26a3ad3237664b
https://doi.org/10.1016/j.bmcl.2008.08.029
https://doi.org/10.1016/j.bmcl.2008.08.029
Autor:
Ingo H. Engels, Jie Xu, Andrew M. Schumacher, Mauricio Montal, Ardem Patapoutian, David C. Tully, Michael Bandell, Bertrand Coste, H. Michael Petrassi, Truc Huynh, Adrienne E. Dubin, Jianmin Lao, Jayanti Mathur, Jason T. Matzen, Ruhma Syeda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccc77fd24b055190a28d6739a4e590f2
https://doi.org/10.7554/elife.07369.008
https://doi.org/10.7554/elife.07369.008
