Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David C. Schröder"'
Autor:
Hendrik Gruß, Rebecca C. Feiner, Ridhiwan Mseya, David C. Schröder, Michał Jewgiński, Kristian M. Müller, Rafał Latajka, Antoine Marion, Norbert Sewald
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1-12 (2022)
The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein–protein interactions, which had been considered undruggable for a long time. We disclose a nove
Externí odkaz:
https://doaj.org/article/b1e73b21829c4343991dd07924fa3253
Autor:
David C. Schröder, Oliver Kracker, Tanja Fröhr, Jerzy Góra, Michał Jewginski, Anke Nieß, Iris Antes, Rafał Latajka, Antoine Marion, Norbert Sewald
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Peptidotriazolamers are hybrid foldamers with features of peptides and triazolamers, containing alternation of amide bonds and 1,4-disubstituted 1H-1,2,3-triazoles with conservation of the amino acid side chains. We report on the synthesis of a new c
Externí odkaz:
https://doaj.org/article/a05e243d3c2b4cdbba7001c557bdf08a
Autor:
Nicolo Tonali, Julia Kaffy, Vadim Le Joncour, David C. Schröder, Pirjo Laakkonen, Loreen Hericks, Antoine Marion, Norbert Sewald, Verónica I. Dodero, Sandrine Ongeri, Oliver Kracker, Radosław Krzemieniecki
Publikováno v:
ChemPlusChem. 86:840-851
In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in molecular weight between small-molecule drugs and protein-based drugs. Amyloid beta (Abeta) aggregates play an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ca106a89c2909fdf080aac3c75cab8
https://doi.org/10.1002/cplu.202000814
https://doi.org/10.1002/cplu.202000814
Autor:
Rebecca C. Feiner, David C. Schröder, Antoine Marion, Norbert Sewald, Isabell Kemker, Kristian M. Müller
Publikováno v:
Journal of Medicinal Chemistry. 64:586-601
An array of l- and d-halotryptophans with different substituents at the indole moiety was synthesized employing either enzymatic halogenation by halogenases or incorporation of haloindoles using tryptophan synthase. Introduction of these Trp derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1771d700ac252daab0af281815a9e64
https://doi.org/10.1021/acs.jmedchem.0c01536
https://doi.org/10.1021/acs.jmedchem.0c01536
Autor:
Lennard Klemme, Nils Janson, Shari Heidemeyer, Beate Neumann, Jens Rudlof, David C. Schröder, Jasmin Simon, Clara Belu, Alessa Hinzmann, Hans-Georg Stammler, Lisa Teichmann, Tanja Fröhr, Philipp Holtkamp, Sebastian Hedwig, Norbert Sewald, Matthias Wünsch
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2428-2441 (2017)
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2428-2441 (2017)
The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8405f053478af0d7c5eecc3efe7b8f
http://europepmc.org/articles/PMC5704752
http://europepmc.org/articles/PMC5704752
Publikováno v:
Journal of medicinal chemistry. 62(16)
Halogenated L- or D-tryptophan obtained by biocatalytic halogenation was incorporated into RGD peptides together with a variety of alkyl or aryl boronic acids. Suzuki-Miyaura cross-coupling either in solution or on-resin results in side chain-to-tail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bb0246c7b559a077665bf8ed3095d0
https://pubmed.ncbi.nlm.nih.gov/31306009
https://pubmed.ncbi.nlm.nih.gov/31306009
Autor:
David C, Schröder, Oliver, Kracker, Tanja, Fröhr, Jerzy, Góra, Michał, Jewginski, Anke, Nieß, Iris, Antes, Rafał, Latajka, Antoine, Marion, Norbert, Sewald
Publikováno v:
Frontiers in Chemistry
Peptidotriazolamers are hybrid foldamers with features of peptides and triazolamers, containing alternation of amide bonds and 1,4-disubstituted 1H-1,2,3-triazoles with conservation of the amino acid side chains. We report on the synthesis of a new c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3dd80e0508fa8fb37a22b85314b1b07d
https://pubmed.ncbi.nlm.nih.gov/30972322
https://pubmed.ncbi.nlm.nih.gov/30972322
Autor:
Dena Lyras, Stephen G. Pyne, Zinka Brkic, Isabell Kemker, Andrew J. Tague, Kittiya Somphol, David C. Schröder, Steven M. Wales, Amy McKarral King, Thomas V. Riley, John B. Bremner, Katherine A. Hammer, Paul A. Keller
Thirty two new binaphthyl-based, functionalized oxazole and thiazole peptidomimetics and over thirty five novel leucine-containing intermediate oxazoles and thiazoles were prepared in this study. This includes the first examples of the direct C-5 ary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44f5d5c3f5c789158b834da4c923efe
https://doi.org/10.1039/c5ob01638j
https://doi.org/10.1039/c5ob01638j
Publikováno v:
The journal of physical chemistry. A. 118(34)
3-Methylbutane-1,2,3-tricarboxylic acid (3-MBTCA) is an atmospheric oxidation product of alpha-pinene and has been identified as the most relevant tracer compound for atmospheric terpene secondary organic aerosol (SOA) particles. Little is known, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9459e55afbd6326ce73e972efcc1de
https://pubmed.ncbi.nlm.nih.gov/25099628
https://pubmed.ncbi.nlm.nih.gov/25099628