Zobrazeno 1 - 10
of 242
pro vyhledávání: '"David C. Samuels"'
Publikováno v:
Genes, Vol 14, Iss 6, p 1222 (2023)
Genetic variation in the mitochondrial genome is linked to important biological functions and various human diseases. Recent progress in single-cell genomics has established single-cell RNA sequencing (scRNAseq) as a popular and powerful technique to
Externí odkaz:
https://doaj.org/article/ac7b0f55715f45718b7605a0dc82a62a
Autor:
Dan-Qian Chen, Gang Cao, Hua Chen, Christos P. Argyopoulos, Hui Yu, Wei Su, Lin Chen, David C. Samuels, Shougang Zhuang, George P. Bayliss, Shilin Zhao, Xiao-Yong Yu, Nosratola D. Vaziri, Ming Wang, Dan Liu, Jia-Rong Mao, Shi-Xing Ma, Jin Zhao, Yuan Zhang, You-Quan Shang, Huining Kang, Fei Ye, Xiao-Hong Cheng, Xiang-Ri Li, Li Zhang, Mei-Xia Meng, Yan Guo, Ying-Yong Zhao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find
Externí odkaz:
https://doaj.org/article/4a04997a433f49e4a807e4cf744638af
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Deep learning has made tremendous successes in numerous artificial intelligence applications and is unsurprisingly penetrating into various biomedical domains. High-throughput omics data in the form of molecular profile matrices,
Externí odkaz:
https://doaj.org/article/eaa4552770f34fe7bf2b67577ae2427a
Autor:
Bing Feng, William Hoskins, Yan Zhang, Zibo Meng, David C. Samuels, Jiandong Wang, Ruofan Xia, Chao Liu, Jijun Tang, Yan Guo
Publikováno v:
BMC Medical Genomics, Vol 11, Iss S5, Pp 25-33 (2018)
Abstract Background Human Down syndrome (DS) is usually caused by genomic micro-duplications and dosage imbalances of human chromosome 21. It is associated with many genomic and phenotype abnormalities. Even though human DS occurs about 1 per 1,000 b
Externí odkaz:
https://doaj.org/article/d43044b5a7c940dbaa1e1bbb3ea5aefc
Autor:
Michael Chigaev, Hui Yu, David C. Samuels, Quanhu Sheng, Olufunmilola Oyebamiji, Scott Ness, Wei Yue, Ying-yong Zhao, Yan Guo
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/fc2dfd4f5d8f41bfb0f8c70c1162599c
Autor:
Stephanie M. Patton, Quan Wang, Todd Hulgan, James R. Connor, Peilin Jia, Zhongming Zhao, Scott L. Letendre, Ronald J. Ellis, William S. Bush, David C. Samuels, Donald R. Franklin, Harpreet Kaur, Jennifer Iudicello, Igor Grant, Asha R. Kallianpur
Publikováno v:
Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in HIV-infected (HIV+)
Externí odkaz:
https://doaj.org/article/815b6bf53baa4687a91a7d9e0e549058
Autor:
David C. Samuels, Asha R. Kallianpur, Ronald J. Ellis, William S. Bush, Scott Letendre, Donald Franklin, Igor Grant, Todd Hulgan
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 2, Pp 330-351 (2017)
Background: Mitochondrial DNA (mtDNA) haplogroups are ancestry-related patterns of single-nucleotide polymorphisms that are associated with differential mitochondrial function in model systems, neurodegenerative diseases in HIV-negative populations,
Externí odkaz:
https://doaj.org/article/e8baafaf97d14acbb488dd41465bdac5
Autor:
Michael Chigaev, Hui Yu, David C. Samuels, Quanhu Sheng, Olufunmilola Oyebamiji, Scott Ness, Wei Yue, Ying-yong Zhao, Yan Guo
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
RNA editing is phenomenon that occurs in both protein coding and non-coding RNAs. Increasing evidence have shown that adenosine-to-inosine RNA editing can potentially rendering substantial functional effects throughout the genome. Using RNA editing d
Externí odkaz:
https://doaj.org/article/07af145d5ae1403aab0eb546d2ce52f8
Autor:
Limin Jiang, Fei Guo, Jijun Tang, Shuguan Leng, Scott Ness, Fei Ye, Huining Kang, David C. Samuels, Yan Guo
Publikováno v:
Cancers, Vol 12, Iss 12, p 3646 (2020)
Global autozygosity quantifies the genome-wide levels of homozygous and heterozygous variants. It is the signature of non-random reproduction, though it can also be driven by other factors, and has been used to assess risk in various diseases. Howeve
Externí odkaz:
https://doaj.org/article/4fd51224c5494e9f9374fb0f377aa95e
Publikováno v:
Genes, Vol 8, Iss 12, p 366 (2017)
Non-coding ribonucleic acid (RNA) has without a doubt captured the interest of biomedical researchers. The ability to screen the entire human genome with high-throughput sequencing technology has greatly enhanced the identification, annotation and pr
Externí odkaz:
https://doaj.org/article/914048d000b64fd79f06dfde45ab4449