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of 40
pro vyhledávání: '"David C. Reeves"'
Publikováno v:
Neuron. 74(4):706-718
Summary Circadian rhythms offer an excellent opportunity to dissect the neural circuits underlying innate behavior because the genes and neurons involved are relatively well understood. We first sought to understand how Drosophila clock neurons inter
Publikováno v:
The Journal of General Physiology
5-HT3A receptors select among permeant ions based on size and charge. The membrane-associated (MA) helix lines the portals into the channel’s cytoplasmic vestibule in the 4-Å resolution structure of the homologous acetylcholine receptor. 5-HT3A MA
Publikováno v:
Neuron. 68:964-977
Intercellular signaling is important for accurate circadian rhythms. In Drosophila, the small ventral lateral neurons (s-LN(v)s) are the dominant pacemaker neurons and set the pace of most other clock neurons in constant darkness. Here we show that t
Publikováno v:
The Journal of Neuroscience. 25:9358-9366
Based on theTorpedoacetylcholine receptor structure, Unwin and colleagues (Miyazawa et al., 2003; Unwin, 2005) hypothesized that the transduction of agonist binding to channel gate opening involves a “pin-into-socket” interaction between αV46 at
Publikováno v:
Biophysical Journal. 84(4):2338-2344
5-HT(3) receptors demonstrate significant structural and functional homology to other members of the Cys-loop ligand-gated ion channel superfamily. The extracellular domains of these receptors share similar sequence homology (approximately 20%) with
Autor:
David C. Reeves, Sarah C. R. Lummis
Publikováno v:
Molecular Membrane Biology. 19:11-26
The ligand-gated ion channel superfamily of neurotransmitter receptors are proteins responsible for rapid transmission of nerve impulses at the synapse and have, therefore, been the subject of intensive research for many years. The cys-loop family, o
Publikováno v:
Journal of Biological Chemistry. 276:42035-42042
5-HT(3) receptors are members of the Cys loop family of ligand-gated ion channels. We used the substituted cysteine accessibility method to identify amino acid residues in the channel forming domain, M2 that face the water-accessible surface and to l
Autor:
David C. Reeves, Paul D. Roepe, David A. Liebelt, David A. Fidock, Viswanathan Lakshmanan, Myles H. Akabas
The emergence of chloroquine-resistant Plasmodium falciparum malaria imperils the lives of millions of people in Africa, Southeast Asia and South America. Chloroquine resistance is associated with mutations in the Plasmodium falciparum chloroquine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b400c7370a8c43e3bcbb9bd211416f7d
https://europepmc.org/articles/PMC1687154/
https://europepmc.org/articles/PMC1687154/
Autor:
David C. Reeves, Sarah C. R. Lummis
Publikováno v:
BMC Neuroscience, Vol 7, Iss 1, p 27 (2006)
BMC Neuroscience
BMC Neuroscience
Background The 5-HT3 receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABAA, and glycine receptors. While antibodies specific for the 5-HT3A receptor subunit are plentiful, and have revealed
Autor:
P.-L. Chau, Sarah C. R. Lummis, Andrew J. Thompson, S. Ling Chan, David C. Reeves, Kerry L. Price
Publikováno v:
The Journal of biological chemistry. 280(21)
We have used a homology model of the extracellular domain of the 5-HT(3) receptor to dock granisetron, a 5-HT(3) receptor antagonist, into the binding site using AUTODOCK. This yielded 13 alternative energetically favorable models. The models fell in