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pro vyhledávání: '"David C. Piper"'
Publikováno v:
European Journal of Neuroscience. 12:726-730
Orexin-A is a novel neuropeptide initially isolated from hypothalamic extracts but now known to be present in fibres distributed throughout the rat CNS including many regions associated with sleep–wake regulation. The recognition of a particularly
Autor:
T.L. Gager, Ian Thomson Forbes, J. Cilia, Peter Ham, Baxter Gordon Smith, David R. Thomas, Guy A. Kennett, Thomas P. Blackburn, Martyn D. Wood, F. Bright, David C. Piper
Publikováno v:
British Journal of Pharmacology. 117:427-434
1. SB 206553 (5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2 ,3-f]indole) displays a high affinity (pK1 7.9) for the cloned human 5-HT2C receptor expressed in HEK 293 cells and the 5-HT2B receptor (pA2 8.9) as measured in the rat stomach
Autor:
David Bolton, Ian Thomson Forbes, Mervyn Thompson, David C. Piper, Clare.J. Hayward, David R. Thomas, Neil Upton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1941-1946
A novel series of 4-amino-pyrido[2,3-b]indoles is presented as GABA A modulators with good potential as therapeutic agents for the treatment of anxiety disorders.
Autor:
David C. Piper, Margaret G. Cutler
Publikováno v:
Psychopharmacology. 101(2)
The 5-HT3 receptor antagonist BRL 43694 was administered in drinking fluid to Mongolian gerbils, previously selected for their propensity to exhibit seizures on mild stimulation, for 11 days at doses of 1.5 micrograms/kg, 150 micrograms/kg and 1 mg/k
Publikováno v:
Drug Development Research. 1:77-82
RU 31124, a new anticonvulsant 1,4-benzodiazepine was compared with clonazepam in a series of tests in rats and mice. It demonstrated greater anticonvulsant potency whilst having equivalent sedative properties to clonazepam. This profile of activity
Autor:
Colin R. Gardner, David C. Piper
Publikováno v:
European journal of pharmacology. 83(1-2)
On the holeboard, exploration (dipping) and locomotion of mice were enhanced by non-sedative doses of anxiolytics; clobazam, diazepam, nitrazepam and flunitrazepam. After chronic dosing the sedative effects of flunitrazepam showed tolerance and the i