Zobrazeno 1 - 10
of 51
pro vyhledávání: '"David C. Montgomery"'
Autor:
Stephen D. Fox, Michael P. Washburn, Laurence Florens, Abigail L. Thorpe, Sarah E. Bergholtz, Jose L Montano, Thorkell Andresson, Jordan L. Meier, Mihaela E. Sardiu, Kellie D. Nance, Qishan Lin, Michaella J. Levy, David C. Montgomery
Publikováno v:
Cell Chem Biol
The plant cell cycle is tightly regulated by factors that integrate endogenous cues and environmental signals to adapt plant growth to changing conditions. Under drought, cell division in young leaves is blocked by an active mechanism, reducing the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d08368445f1a8fab7a08e3060173edd
https://europepmc.org/articles/PMC8237707/
https://europepmc.org/articles/PMC8237707/
Autor:
David Wildes, John E. Knox, Daniel M. Whalen, Carlos Stahlhut, Cregg James Joseph, Abby Marquez, Mae Saldajeno-Concar, Adrian Liam Gill, Elena S. Koltun, Frances Zhao, Severin K. Thompson, Nataliya Tobvis Shifrin, Richard Hansen, Micah J. Gliedt, Mallika Singh, Mengqi Zhong, Naing Aay, Lindsay S. Garrenton, Ruiping Zhao, Elsa Quintana, Bao Nguyen, Laura L. McDowell, Jong Choi, Arlyn Tambo-Ong, Andreas Buckl, David C. Montgomery, Atti Tripathi, Alun Bermingham, Zhengping Wang, Jan A. Smith, Grace J. Lee, Daphne Hsieh
Publikováno v:
Cancer Research. 81:1273-1273
The guanine nucleotide exchange factor (GEF) protein SOS1 activates RAS by promoting its conversion from the GDP-bound RAS(OFF) state to the GTP-bound RAS(ON) state. SOS1 catalyzes or accelerates this nucleotide exchange reaction in response to upstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84529dd9e8d7b5ae744e473068a78025
https://doi.org/10.1158/1538-7445.am2021-1273
https://doi.org/10.1158/1538-7445.am2021-1273
Publikováno v:
Curr Opin Chem Biol
Altered metabolite levels are now well-established to drive epigenetic changes in development and disease. However, in many cases the specific protein–metabolite interactions that underlie this process remain enigmatic. In this review, we make the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b16b7678b8b369a16dfbca9505e1057
https://pubmed.ncbi.nlm.nih.gov/30884380
https://pubmed.ncbi.nlm.nih.gov/30884380
Autor:
Ajit Jadhav, Madhu Lal-Nag, Jordan L. Meier, David C. Montgomery, Neil K. Tiwari, Alexander W. Sorum, Anton Simeonov, Allison M. Roberts, Jonathan H. Shrimp
Publikováno v:
ACS Chemical Biology. 11:734-741
Lysine acetyltransferases (KATs) are critical regulators of signaling in many diseases, including cancer. A major challenge in establishing the targetable functions of KATs in disease is a lack of well-characterized, cell-active KAT inhibitors. To co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e6a1d157e48d3976228ed4bb431803
https://doi.org/10.1021/acschembio.5b00709
https://doi.org/10.1021/acschembio.5b00709
Publikováno v:
Chemistry & Biology. 22:1030-1039
SummaryThe finding that chromatin modifications are sensitive to changes in cellular cofactor levels potentially links altered tumor cell metabolism and gene expression. However, the specific enzymes and metabolites that connect these two processes r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc711aadb9f5618561dc41e0e87e62f
https://doi.org/10.1016/j.chembiol.2015.06.015
https://doi.org/10.1016/j.chembiol.2015.06.015
Publikováno v:
ACS Chemical Biology
Long known for their role in histone acetylation, recent studies have demonstrated that lysine acetyltransferases also carry out distinct “orphan” functions. These activities impact a wide range of biological phenomena including metabolism, RNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9578facd5659cb59e06417d237ff43e2
https://doi.org/10.1021/cb500853p
https://doi.org/10.1021/cb500853p
Autor:
Thomas Zengeya, Jordan L. Meier, Stephen D. Fox, David C. Montgomery, Daniel Arango, Wilson R. Sinclair, Justin M. Thomas, Jonathan H. Shrimp, Shalini Oberdoerffer, Thorkell Andresson
Publikováno v:
ACS Chem Biol
The human acetyltransferase NAT10 has recently been shown to catalyze formation of N4-acetylcytidine (ac4C), a minor nucleobase known to alter RNA structure and function. In order to better understand the role of RNA acetyltransferases in biology and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6d734f73cd4f0d35f8d37db9f43a47
https://pubmed.ncbi.nlm.nih.gov/29039931
https://pubmed.ncbi.nlm.nih.gov/29039931
Autor:
AnnMarie Torres, Joshua L.D. Parris, Sophie Trefely, Alessandro Carrer, John M. Viola, Andrew J. Andrews, Ian A. Blair, Jordan L. Meier, Nathaniel W. Snyder, Ryan A. Henry, Yin-Ming Kuo, David C. Montgomery, Kathryn E. Wellen
Cellular metabolism dynamically regulates the epigenome via availability of the metabolite substrates of chromatin-modifying enzymes. The impact of diet on the metabolism-epigenome axis is poorly understood but could alter gene expression and influen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd459f3bbd4c07e975e2ecae57b2f4d9
https://europepmc.org/articles/PMC5336165/
https://europepmc.org/articles/PMC5336165/
Autor:
Sudipto Das, W. Marston Linehan, Ming Zhou, Rhushikesh A. Kulkarni, David C. Montgomery, Clementina Mesaros, Benjamin K. Gibbs, King C. Chan, Thorkell Andresson, Thomas Zengeya, Julie M. Garlick, Jordan L. Meier, Andrew J. Worth, Allison M. Roberts, Yien Che Tsai, Nathaniel W. Snyder, Ian A. Blair, Jonathan H. Shrimp, Carole Sourbier, Allan M. Weissman
Publikováno v:
Cell chemical biology. 24(2)
Non-enzymatic protein modification driven by thioester reactivity is thought to play a major role in the establishment of cellular lysine acylation. However, the specific protein targets of this process are largely unknown. Here we report an experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3f209bc60dafd56f58b5ee7bfa3f9b
https://pubmed.ncbi.nlm.nih.gov/28212757
https://pubmed.ncbi.nlm.nih.gov/28212757
Autor:
Abdellah Allali-Hassani, Rhushikesh A. Kulkarni, Masoud Vedadi, Julie M. Garlick, Steven Kennedy, David C. Montgomery, Jordan L. Meier, Hong Wu, Yin-Ming Kuo, Andrew J. Andrews
Lysine acetyltransferases (KATs) are key mediators of cell signaling. Methods capable of providing new insights into their regulation thus constitute an important goal. Here we report an optimized platform for profiling KAT-ligand interactions in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfcfd0bd9e8de95a63df7bff0363beb
https://europepmc.org/articles/PMC6320254/
https://europepmc.org/articles/PMC6320254/