Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David C. Moebius"'
Autor:
Erin Bradley, Lisa M. Kelly, Janet L. Anderl, Eric Lowe, David C. Moebius, Jeffrey Jones, Shirin Arastu-Kapur, Christopher J. Kirk, Henry W. B. Johnson, John Bui, Zhengping Wang, Dustin McMinn, Tony Muchamuel
Publikováno v:
ACS Medicinal Chemistry Letters. 8:413-417
Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within the immunoproteasome is of interest for the treatment of autoimmune disease. There are thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baf150fa245ff729c9b833768c2ac19
https://doi.org/10.1021/acsmedchemlett.6b00496
https://doi.org/10.1021/acsmedchemlett.6b00496
Publikováno v:
Organic Letters. 17:3398-3401
A general strategy for the synthesis of polycyclic polyprenylated acylphloroglucinols is described in which a scalable, Lewis acid catalyzed epoxide-opening cascade cyclization is used to furnish common intermediate 4. The utility of this approach is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcf21f3b1f7a72073d92e8ac832bdfe
https://doi.org/10.1021/acs.orglett.5b01121
https://doi.org/10.1021/acs.orglett.5b01121
Publikováno v:
Organic Letters. 13:2004-2007
Current methods for asymmetric α-arylation require blocking groups to prevent reaction at the α'-carbon, basic conditions that promote racemization, or multistep synthesis. This work records the first catalytic enantioselective examples of the diaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d710dc6d0aa01dc985693f408f260d27
https://doi.org/10.1021/ol200402m
https://doi.org/10.1021/ol200402m
Autor:
Jennifer A. Dabrowski, David C. Moebius, Jason S. Kingsbury, Andrew J. Wommack, Anne F. Kornahrens
Publikováno v:
Organic Letters. 12:3598-3601
Divergent reactivity is uncovered in the homologation of arylcyclobutanones with trimethylsilyldiazomethane. With Sc(OTf)(3) as catalyst, enolsilanes are obtained with a high preference for methylene migration. By contrast, Sc(hfac)(3) gives beta-ket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99737bfdbd61d98e0b7565cf348758ef
https://doi.org/10.1021/ol101136a
https://doi.org/10.1021/ol101136a
Publikováno v:
ChemInform. 46
Diazo compounds continue both to challenge and to fascinate practitioners of chemical synthesis. The most strategically powerful and unique type of reactivity observed with these reagents is a formal insertion of the donor-acceptor carbon into C–C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d021a162dce2bc6db569b4128096d9
https://doi.org/10.1002/chin.201547247
https://doi.org/10.1002/chin.201547247
Publikováno v:
Topics in current chemistry. 346
Diazo compounds continue both to challenge and to fascinate practitioners of chemical synthesis. The most strategically powerful and unique type of reactivity observed with these reagents is a formal insertion of the donor-acceptor carbon into C-C or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d9d8c70b71fa0e3424d0241f64ce0ec
https://pubmed.ncbi.nlm.nih.gov/24770564
https://pubmed.ncbi.nlm.nih.gov/24770564
Publikováno v:
Topics in Current Chemistry ISBN: 9783642550546
Diazo compounds continue both to challenge and to fascinate practitioners of chemical synthesis. The most strategically powerful and unique type of reactivity observed with these reagents is a formal insertion of the donor-acceptor carbon into C–C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe9396de956a025bd1fe6b72a2dbeebe
https://doi.org/10.1007/128_2013_521
https://doi.org/10.1007/128_2013_521
Autor:
David C. Moebius, Anne F. Kornahrens, Jason S. Kingsbury, Andrew J. Wommack, Jennifer A. Dabrowski
Publikováno v:
ChemInform. 41
Treatment of cyclobutanones with azo compound (II) in the presence of Sc(F6acac)3 results in selective formation of 2-silylated cyclopentanones of type (III).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22156385e1739d28c11dc530c2b95bdb
https://doi.org/10.1002/chin.201051054
https://doi.org/10.1002/chin.201051054
Publikováno v:
ChemInform. 40
Over a century ago, the first reactions of diazomethane with aldehydes delivered methyl ketones. In the interim, aldehydes have been homologated with trimethylsilyldiazomethane, diazoacetates, and aryldiazomethanes, on rare occasion with catalysis. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ecea7b3e41859a16f7b74a79584e9aa
https://doi.org/10.1002/chin.200948079
https://doi.org/10.1002/chin.200948079
Publikováno v:
Organic letters. 11(15)
Over a century ago, the first reactions of diazomethane with aldehydes delivered methyl ketones. In the interim, aldehydes have been homologated with trimethylsilyldiazomethane, diazoacetates, and aryldiazomethanes, on rare occasion with catalysis. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3472a56e8a39b4c9d6c386441078fab3
https://pubmed.ncbi.nlm.nih.gov/19588908
https://pubmed.ncbi.nlm.nih.gov/19588908