Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David C. Mcgowan"'
Autor:
Kurt Morgenstern, Matthew W. Martin, Faye Hsieh, Stuart C. Chaffee, Susan A. Tomlinson, Susan M. Turci, Joseph J. Nunes, Lilly Chai, Paul E. Rose, Josie H. Lee, Antonio J. Oliveira-dos-Santos, Erin F. DiMauro, Vinod F. Patel, David Powers, Yan Gu, Xin Huang, Jean Bemis, Andrew A. Welcher, David C. Mcgowan, Huilin Zhao, Joseph L. Kim, Xiaotian Zhu, Holly L. Deak, Li Zhu, Yanyan Tudor, Ted Faust, Linda F. Epstein, Christina Boucher, Anu Gore, Deanna Mohn, Stephen Schneider, John Newcomb, Daniela Metz, Brad Henkle, Paul Gallant
Publikováno v:
Journal of Medicinal Chemistry. 51:1681-1694
The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8884d0e69b4d85c6e3a74c4f98b0f
https://doi.org/10.1021/jm7010996
https://doi.org/10.1021/jm7010996
Autor:
Ryan White, David C. Mcgowan, Xiaotian Zhu, Matthew W. Martin, John Newcomb, John L. Buchanan, Theodore Faust, Faye Hsieh, Xin Huang, Erin F. DiMauro, Susan M. Turci, Christina Boucher, Stephen Schneider, Joseph J. Nunes, Jean Bemis, Josie H. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2299-2304
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cec8aa93efe43539a086c398621a2de
https://doi.org/10.1016/j.bmcl.2007.01.048
https://doi.org/10.1016/j.bmcl.2007.01.048
Autor:
Joseph L. Kim, Paul E. Hughes, Brian K. Albrecht, Jenne Fretland, Paul Gallant, David C. Mcgowan, Huilin Zhao, Steve Bellon, Michael Morrison, Victor J. Cee, Vinod F. Patel, Sean Caenepeel, Stephanie D. Geuns-Meyer, Alexander M. Long, Anthony Polverino, James Bready, Ling Wang, Doug Hoffman, Brian L. Hodous, Yan Gu, Paul E. Rose, Angela Coxon, David Powers, Rebecca E. Johnson, Maurice Emery, Richard Kendall, Philip R. Olivieri, Stuart C. Chaffee
Publikováno v:
Journal of Medicinal Chemistry. 50:627-640
The recognition that aberrant angiogenesis contributes to the pathology of inflammatory diseases, cancer, and myocardial ischemia has generated considerable interest in the molecular mechanisms that regulate blood vessel growth. The receptor tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6932d5428aa21ae9088dcbc2e4a337f3
https://doi.org/10.1021/jm061112p
https://doi.org/10.1021/jm061112p
Autor:
Joseph L. Kim, Xiaotian Zhu, William H. Buckner, Josie H. Lee, Vinod F. Patel, Lilly Chai, Antonio J. Oliveira-dos-Santos, Ryan White, Holly L. Deak, Brian L. Hodous, Joseph J. Nunes, John L. Buchanan, Paul E. Rose, Huilin Zhao, Andrew A. Welcher, Stephanie D. Geuns-Meyer, Linda F. Epstein, David Powers, Yan Gu, Stephen Schneider, Kurt Morgenstern, Anu Gore, Victor J. Cee, Yanyan Tudor, Ted Faust, Susan A. Tomlinson, Xin Huang, Erin F. DiMauro, Jean Bemis, Susan M. Turci, John Newcomb, David C. Mcgowan, Faye Hsieh, Brad Henkle, Deanna Mohn, Christina Boucher, Li Zhu, Matthew W. Martin, Paul Gallant, Craig E. Masse, Daniela Metz
Publikováno v:
Journal of Medicinal Chemistry. 49:5671-5686
The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbddeb8cdb894dbfd55fa63c5040ddcf
https://doi.org/10.1021/jm0605482
https://doi.org/10.1021/jm0605482
Autor:
Alan C. Cheng, Ryan White, Stephen Schneider, Joseph J. Nunes, John L. Buchanan, Jean Bemis, Faye Hsieh, William H. Buckner, Susan M. Turci, Matthew W. Martin, Christina Boucher, John Newcomb, Xin Huang, Xiaotian Zhu, Josie H. Lee, Theodore Faust, Erin F. DiMauro, David C. Mcgowan, Teresa L. Marshall
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
4-Amino-5,6-biaryl-furo[2,3-d]pyrimidines were identified as potent non-selective inhibitors of Lck. A novel, divergent, and practical synthetic route was developed to access derivatives from bifunctional intermediates. Lead optimization was guided b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8596032c12f0ec265ab314e83b4a1d9
https://pubmed.ncbi.nlm.nih.gov/17280833
https://pubmed.ncbi.nlm.nih.gov/17280833
Autor:
Debra Zack, David C. Mcgowan, Xiaotian Zhu, Linda F. Epstein, Antonio J. Oliveira-dos-Santos, Ryan White, Christina Boucher, Stephen Schneider, David Powers, Faye Hsieh, Josie H. Lee, Patricia Amouzegh, Huilin Zhao, Spencer Napier, Monika Ermann, Scot Middleton, Daniel Elbaum, Joseph J. Nunes, Xin Huang, Matthew W. Martin, Yanyan Tudor, Paul Gallant, Li Zhu, David N. Johnston, Yan Gu, Kurt Morgenstern, Susan M. Turci, Eoin Christopher Power, Paul E. Rose, Michael Morrison, Theodore Faust, Perry M. Novak, William H. Buckner, Lilly Chai, Jenkins James Edward, Shaun Flynn, John L. Buchanan, Deanna Mohn, Stephanie Sell, Andrew A. Welcher, Daniela Metz, Anu Gore, Chiara Ghiron, John Newcomb, Armistead David M
Publikováno v:
Journal of medicinal chemistry. 49(16)
The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c5809a6ff227128ca92887aa829a19
https://pubmed.ncbi.nlm.nih.gov/16884310
https://pubmed.ncbi.nlm.nih.gov/16884310
Autor:
GeorgeP. Liao, Eman M. M. Abdelraheem, Constantinos G. Neochoritis, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, David C. McGowan, Alexander Dömling
Publikováno v:
Organic Letters; Oct2015, Vol. 17 Issue 20, p4980-4983, 4p
Autor:
John Newcomb, John L. Buchanan, Susan M. Turci, Joseph J. Nunes, Xin Huang, Stephen Schneider, Ryan White, Faye Hsieh, Matthew W. Martin, Josie H. Lee, Xiaotian Zhu, David C. Mcgowan, Christina Boucher, Jean Bemis, Erin F. DiMauro, Theodore Faust
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13f797b92f44e6f0dbc14510c01dd6fc
https://doi.org/10.1016/j.bmcl.2007.05.003
https://doi.org/10.1016/j.bmcl.2007.05.003
Autor:
Ryan White, Joseph J. Nunes, Josie H. Lee, Matthew W. Martin, Jean Bemis, Susan M. Turci, David C. Mcgowan, Xiaotian Zhu, Christina Boucher, Teresa L. Marshall, Stephen Schneider, John L. Buchanan, Alan C. Cheng, Xin Huang, John Newcomb, Erin F. DiMauro, Theodore Faust, William H. Buckner, Faye Hsieh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fca01280d3f4739a3e7284575e27e92
https://doi.org/10.1016/j.bmcl.2007.05.002
https://doi.org/10.1016/j.bmcl.2007.05.002
Autor:
Erin F. DiMauro, John Newcomb, Joseph J. Nunes, Jean E. Bemis, Christina Boucher, Lilly Chai, Stuart C. Chaffee, Holly L. Deak, Linda F. Epstein, Ted Faust, Paul Gallant, Anu Gore, Yan Gu, Brad Henkle, Faye Hsieh, Xin Huang, Joseph L. Kim, Josie H. Lee, Matthew W. Martin, David C. McGowan
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1681-1694, 14p