Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David C. McKinney"'
Autor:
Lucie Miller-Potucka, Gall Malcolm Allan Young, Ian W. Ashworth, Andrew J. Robbins, Oliver T. Ring, Martin F. Jones, Barry R. Hayter, Rosemary A. Wordsworth, Adam J. Leahy, Lyn Powell, Phillip A. Inglesby, Alex L. Lamacraft, Okky Dwichandra Putra, Janette H. Cherryman, Thomas O. Ronson, Peter R. Hamilton, Simone Tomasi, Lauren R. Agnew, David C. McKinney
Publikováno v:
Organic Process Research & Development. 26:936-948
Autor:
Dale Porter, Alessandra Ianari, Merissa Brousseau, Patrick McCarren, Foxy P. Robinson, Adam Skepner, Virendar K. Kaushik, Kathleen M. Mulvaney, Arthur J. Campbell, Martin J Drysdale, Zachary Mullin-Bernstein, Brian J. McMillan, Robert Hilgraf, Ritu Singh, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, David C. McKinney, Jamie A. Moroco, Michael F. Mesleh, David E. Timm, Besnik Bajrami, Florence F. Wagner
Publikováno v:
J Med Chem
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Autor:
Zhang Enxuan, Chris D. Parsons, David C. McKinney, Kevin William Leslie, Zhi-qing Liu, Miguel Gonzalez, Mark A. Graham, Jackson Lucinda Victoria, Rachel H. Munday, Jun-wang Zhang, Janette H. Cherryman, James Douglas, David Whittaker, Gary M. Noonan
Publikováno v:
Organic Process Research & Development. 25:57-67
New route development activities toward ceralasertib (AZD6738) have resulted in the discovery of an efficient, acid additive-free, photoredox Minisci reaction. Mechanistic understanding resulting f...
Autor:
Andrew J. Aguirre, Nischal Acharya, Adam Skepner, Christa Blomquist, David C. McKinney, Michael J. Young, Meghan O’Keefe, Ruitong Li, Debjani Pal, Kathleen M. Mulvaney, Yelena Freyzon, Matthew E. Stokes, Fazli K. Bozal, Donald Raymond, Matthew J. Ranaghan, Devishi Kesar, Diego J. Rodriguez, Yossef Baidi, Annan Yang, William R. Sellers, Sidharth S. Jain, Dale Porter, Salvatore LaRussa, Alessandra Ianari, Josie Columbus, Zachary Mullin-Bernstein, Alissa J. Nelson, Brian J. McMillan
Publikováno v:
Mol Cell
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c286957885746d63e5b3ac89688c8b85
https://europepmc.org/articles/PMC9016627/
https://europepmc.org/articles/PMC9016627/
Autor:
Ritu Singh, Michael F. Mesleh, Matthew J. Ranaghan, Virendar K. Kaushik, Dale Porter, Brian J. McMillan, Kathleen M. Mulvaney, Alessandra Ianari, David E. Timm, William R. Sellers, Besnik Bajrami, Patrick McCarren, Meghan O’Keefe, David C. McKinney, Merissa Brousseau, Zachary Mullin-Bernstein, Jamie A. Moroco, Adam Skepner
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6860a9dce9163efa6957c5be29c743
https://doi.org/10.1101/2021.02.03.429644
https://doi.org/10.1101/2021.02.03.429644
Autor:
Yossef Baidi, Brian J. McMillan, Alissa J. Nelson, Josie Columbus, Sidharth S. Jain, Nischal Acharya, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, Kathleen M. Mulvaney, Yelena Freyzon, Fazli K. Bozal, Christa Blomquist, Ruitong Li, Adam Skepner, David C. McKinney, Dale Porter, Alessandra Ianari, Donald Raymond, Matthew E. Stokes
PRMT5 is an arginine methyltransferase and a therapeutic target in MTAP null cancers. PRMT5 utilizes adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequence s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45336005291024a9907c2480940f06f2
https://doi.org/10.1101/2020.08.22.256347
https://doi.org/10.1101/2020.08.22.256347
Autor:
Gloria Anne Breault, David C. McKinney, Adam B. Shapiro, Sushmita D. Lahiri, Jun Hu, Rong-Fang Gu, Andrew R. McKenzie, Steven L. Kazmirski, Charles J. Eyermann
Publikováno v:
ACS Infectious Diseases. 2:456-464
Fatty acid biosynthesis is essential to bacterial growth in Gram-negative pathogens. Several small molecules identified through a combination of high-throughput and fragment screening were cocrystallized with FabH (β-ketoacyl-acyl carrier protein sy
Autor:
Kathleen M. Mulvaney, B. Besnik, Meghan O’Keefe, Jamie A. Moroco, William R. Sellers, Ritu Singh, Alessandra Ianari, Merissa Brousseau, David C. McKinney, Matthew J. Ranaghan, Brian J. McMillan, Patrick McCarren
Publikováno v:
European Journal of Cancer. 138:S1
Autor:
Jonathan A. Rose, Paul Robert Fleming, Adam B. Shapiro, David C. McKinney, Stewart L. Fisher, Rob Albert, Marshall Morningstar, Sushmita D. Lahiri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3301-3306
With increasing emergence of multi-drug resistant infections, there is a dire need for new classes of compounds that act through unique mechanisms. In this work, we describe the discovery and optimization of a novel series of inhibitors of bacterial
Autor:
David C. McKinney, Fei Zhou, Charles J. Eyermann, J Breen, Robert A. Giacobbe, A.D. Ferguson, Jeroen C. Verheijen, Sushmita D. Lahiri, D.B Prince
Publikováno v:
ACS Infectious Diseases. 1:310-316
Bacterially expressed β-lactamases are rapidly eroding the clinical utility of the important β-lactam class of antibacterials, significantly impairing our ability to fight serious bacterial infections. This paper describes a study of oxaborole-deri