Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David C. Luther"'
Autor:
Rui Huang, David C. Luther, Xianzhi Zhang, Aarohi Gupta, Samantha A. Tufts, Vincent M. Rotello
Publikováno v:
Nanomaterials, Vol 11, Iss 4, p 1001 (2021)
Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight app
Externí odkaz:
https://doaj.org/article/430acdfbb5a04add9b2ed65b1c29f187
Autor:
Taewon Jeon, David C. Luther, Ritabrita Goswami, Charlotte Bell, Harini Nagaraj, Yagiz Anil Cicek, Rui Huang, Javier A. Mas-Rosario, James L. Elia, Jungkyun Im, Yi-Wei Lee, Yuanchang Liu, Federica Scaletti, Michelle E. Farkas, Jesse Mager, Vincent M. Rotello
Publikováno v:
ACS Nano. 17:4315-4326
Autor:
David C. Luther, Yi-Wei Lee, Harini Nagaraj, Vincent Clark, Taewon Jeon, Ritabrita Goswami, Sanjana Gopalakrishnan, Stefano Fedeli, William Jerome, James L. Elia, Vincent M. Rotello
Publikováno v:
ACS Nano. 16:7323-7330
Current strategies for the delivery of proteins into cells face general challenges of endosomal entrapment and concomitant degradation of protein cargo. Efficient delivery directly to the cytosol overcomes this obstacle: we report here the use of bio
Direct Cytosolic Delivery of Proteins Using Lyophilized and Reconstituted Polymer-Protein Assemblies
Autor:
David C. Luther, Harini Nagaraj, Ritabrita Goswami, Yağız Anıl Çiçek, Taewon Jeon, Sanjana Gopalakrishnan, Vincent M. Rotello
Publikováno v:
Pharmaceutical Research. 39:1197-1204
Cytosolic delivery of proteins accesses intracellular targets for chemotherapy and immunomodulation. Current delivery systems utilize inefficient endosomal pathways of uptake and escape that lead to degradation of delivered cargo. Cationic poly(oxano
Autor:
Moumita Ray, Giorgia Brancolini, David C. Luther, Ziwen Jiang, Roberto Cao-Milán, Alejandro M. Cuadros, Andrew Burden, Vincent Clark, Subinoy Rana, Rubul Mout, Ryan F. Landis, Stefano Corni, Vincent M. Rotello
Publikováno v:
Nanoscale
Nanoscale, vol 14, iss 6
Nanoscale (Online) 14 (2022): 2411–2418. doi:10.1039/d1nr07497k
info:cnr-pdr/source/autori:Ray M.; Brancolini G.; Luther D.C.; Jiang Z.; Cao-Milan R.; Cuadros A.M.; Burden A.; Clark V.; Rana S.; Mout R.; Landis R.F.; Corni S.; Rotello V.M./titolo:High affinity protein surface binding through co-engineering of nanoparticles and proteins/doi:10.1039%2Fd1nr07497k/rivista:Nanoscale (Online)/anno:2022/pagina_da:2411/pagina_a:2418/intervallo_pagine:2411–2418/volume:14
Nanoscale, vol 14, iss 6
Nanoscale (Online) 14 (2022): 2411–2418. doi:10.1039/d1nr07497k
info:cnr-pdr/source/autori:Ray M.; Brancolini G.; Luther D.C.; Jiang Z.; Cao-Milan R.; Cuadros A.M.; Burden A.; Clark V.; Rana S.; Mout R.; Landis R.F.; Corni S.; Rotello V.M./titolo:High affinity protein surface binding through co-engineering of nanoparticles and proteins/doi:10.1039%2Fd1nr07497k/rivista:Nanoscale (Online)/anno:2022/pagina_da:2411/pagina_a:2418/intervallo_pagine:2411–2418/volume:14
Control over supramolecular recognition between proteins and nanoparticles (NPs) is of fundamental importance in therapeutic applications and sensor development. Most NP-protein binding approaches use 'tags' such as biotin or His-tags to provide high
Autor:
Riddha Das, Joseph Hardie, Bishnu P. Joshi, Xianzhi Zhang, Aarohi Gupta, David C. Luther, Stefano Fedeli, Michelle E. Farkas, Vincent M. Rotello
Publikováno v:
JACS Au. 2(7)
Macrophages migrate to tumor sites by following chemoattractant gradients secreted by tumor cells, providing a truly active targeting strategy for cancer therapy. However, macrophage-based delivery faces challenges of cargo loading, control of releas
Autor:
Ahmed Nabawy, Rui Huang, David C. Luther, Xianzhi Zhang, Cheng-Hsuan Li, Jessa Marie Makabenta, Vincent M. Rotello
Publikováno v:
Chemical science. 13(41)
An all-natural biopolymer-based nanoemulsion catalyst for combatting MDR bacterial biofilms while maintaining excellent biocompatibility and biodegradability.
Autor:
Taewon Jeon, Vincent M. Rotello, Yi-Wei Lee, Cameron W. Evans, Marck Norret, William Jerome, Sanjana Gopalakrishnan, K. Swaminathan Iyer, Jessica A. Kretzmann, David C. Luther
Publikováno v:
Journal of the American Chemical Society. 143:4758-4765
Intracellular protein delivery enables selective regulation of cellular metabolism, signaling, and development through introduction of defined protein quantities into the cell. Most applications require that the delivered protein has access to the cy
Autor:
Hira Lal Goel, Xianzhi Zhang, Arthur M. Mercurio, Vincent M. Rotello, Melanie R Walker, John J. Amante, Yingying Geng, David C. Luther
Publikováno v:
ACS Nano. 14:15276-15285
Cancer stem cells (CSCs) are a crucial therapeutic target because of their role in resistance to chemo- and radiation therapy, metastasis, and tumor recurrence. Differentiation therapy presents a potential strategy for "defanging" CSCs. To date, only
Autor:
Mingdi Jiang, Aritra Nath Chattopadhyay, Cheng Hsuan Li, Yingying Geng, David C. Luther, Rui Huang, Vincent M. Rotello
Publikováno v:
Chemical science. 13(43)
Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis. Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful ha