Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David C. Kohrman"'
Autor:
Ken Hashimoto, Tyler T. Hickman, Jun Suzuki, Lingchao Ji, David C. Kohrman, Gabriel Corfas, M. Charles Liberman
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks
Externí odkaz:
https://doaj.org/article/ee0860e21d1648468a10153d8c2a20c3
Autor:
Richard A. Altschuler, Lisa Kabara, Catherine Martin, Ariane Kanicki, Courtney E. Stewart, David C. Kohrman, David F. Dolan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Our previous study demonstrated rapamycin added to diet at 4 months of age had significantly less age-related outer hair cell loss in the basal half of the cochlea at 22 months of age compared to mice without rapamycin. The present study tested addin
Externí odkaz:
https://doaj.org/article/edef4ca3d8434093b1b984eddb737d57
Autor:
Matthew R Avenarius, Jae-Yun Jung, Charles Askew, Sherri M Jones, Kristina L Hunker, Hela Azaiez, Atteeq U Rehman, Margit Schraders, Hossein Najmabadi, Hannie Kremer, Richard J H Smith, Gwenaëlle S G Géléoc, David F Dolan, Yehoash Raphael, David C Kohrman
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201713 (2018)
Hearing and balance depend upon the precise morphogenesis and mechanosensory function of stereocilia, the specialized structures on the apical surface of sensory hair cells in the inner ear. Previous studies of Grxcr1 mutant mice indicated a critical
Externí odkaz:
https://doaj.org/article/1b9954a009804b34a68d58ca662b8503
Autor:
Luis R. Cassinotti, Lingchao Ji, Beatriz C. Borges, Nathan D. Cass, Aditi S. Desai, David C. Kohrman, M. Charles Liberman, Gabriel Corfas
Publikováno v:
Aging cell. 21(10)
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive pathology often has psychological and medical comorbidities, including social isolation, depression, and cognitive decline. Despite ARHL's enormous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b78a9ee1796ea9711e35d64356471dc
https://pubmed.ncbi.nlm.nih.gov/36088647
https://pubmed.ncbi.nlm.nih.gov/36088647
Publikováno v:
Dev Neurobiol
The auditory system detects and encodes sound information with high precision to provide a high-fidelity representation of the environment and communication. In mammals, detection occurs in the peripheral sensory organ (the cochlea) containing specia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ab117cba993139c1ae179fae126b2a
https://doi.org/10.1002/dneu.22813
https://doi.org/10.1002/dneu.22813
Autor:
Richard A, Altschuler, Courtney E, Stewart, Lisa, Kabara, Catherine A, Martin, Ariane, Kanicki, David C, Kohrman, David F, Dolan
Publikováno v:
Hearing Research. 424:108601
Many factors contribute to hearing loss commonly found in older adults. There can be natural aging of cellular elements, hearing loss previously induced by environmental factors such as noise or ototoxic drugs as well as genetic and epigenetic influe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741674941d205808fa957554a2ae9df9
https://doi.org/10.1016/j.heares.2022.108601
https://doi.org/10.1016/j.heares.2022.108601
Publikováno v:
Otolaryngology–Head and Neck Surgery. 156:1114-1118
Experience with procurement of research funding and grantsmanship is an essential skill and one that is rarely taught in a manner that adequately prepares trainees for the magnitude of this professional requirement. The aims of the program described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e030846a5e6e8a5bda4bb64512837031
https://doi.org/10.1177/0194599816683383
https://doi.org/10.1177/0194599816683383
Autor:
David C. Kohrman, Gabriel Corfas, M. Charles Liberman, Ken Hashimoto, Jun Suzuki, Lingchao Ji, Tyler T. Hickman
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks were inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec973ec996472d70c6f77f4375b0220
http://europepmc.org/articles/PMC6814859
http://europepmc.org/articles/PMC6814859
Adding rapamycin or acarbose to diet at 9-10 months of age has been shown to significantly increase life span in both male and female UM-HET3 mice. The current study examined cochleae of male and female UM-HET3 mice at 22 months of age to determine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8eacc155cb3d90e2d76f78be224217
https://europepmc.org/articles/PMC6240471/
https://europepmc.org/articles/PMC6240471/
Autor:
Hannie Kremer, Margit Schraders, Yehoash Raphael, Richard J.H. Smith, Atteeq U. Rehman, Jae Yun Jung, Kristina L. Hunker, Hela Azaiez, Hossein Najmabadi, David F. Dolan, Sherri M. Jones, Gwenaëlle S. G. Géléoc, David C. Kohrman, Matthew R. Avenarius, Charles Askew
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201713 (2018)
PLoS One, 13, 8
PLoS One, 13
PLoS One, 13, 8
PLoS One, 13
Contains fulltext : 196393.pdf (Publisher’s version ) (Open Access) Hearing and balance depend upon the precise morphogenesis and mechanosensory function of stereocilia, the specialized structures on the apical surface of sensory hair cells in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b56c789e206ded76ec4c0cbf03b552
http://europepmc.org/articles/PMC6114524?pdf=render
http://europepmc.org/articles/PMC6114524?pdf=render