Zobrazeno 1 - 10
of 97
pro vyhledávání: '"David C. Kem"'
Autor:
Elizabeth A. Weedin, D.O., M.S., Heather R. Burks, M.D., Xichun Yu, M.D., Hong Liang Li, M.D., Ph.D., Christopher E. Aston, Ph.D., David C. Kem, M.D., LaTasha B. Craig, M.D.
Publikováno v:
F&S Reports, Vol 1, Iss 3, Pp 299-304 (2020)
Objectives: 1) To confirm the correlation of GnRH receptor (GnRHR) activating autoantibody (AAb) activity with polycystic ovary syndrome (PCOS) diagnosis in large well defined cohorts; and 2) to evaluate suppression of AAb activity with GnRH antagoni
Externí odkaz:
https://doaj.org/article/f8d9c4eafd224b61ab75ad39171aa42a
Autor:
Hongliang Li, Gege Zhang, Yankai Guo, Jielin Deng, Hayley Fischer, LaTasha B. Craig, David C. Kem, Xichun Yu
Publikováno v:
Physiological Reports, Vol 8, Iss 24, Pp n/a-n/a (2021)
Abstract Polycystic ovary syndrome (PCOS), a metabolic and reproductive disease, is frequently associated with type 2 diabetes. We have demonstrated activating autoantibodies (AAb) directed toward the second extracellular loop (ECL2) of the gonadotro
Externí odkaz:
https://doaj.org/article/8f6cae1aa000431a9f560a0dfdd209ce
Autor:
Thariq Badiudeen, Elizabeth A. Forsythe, Graham Bennett, Hongliang Li, Xichun Yu, Marci Beel, Zachary Nuss, Kenneth E. Blick, Luis E. Okamoto, Amy C. Arnold, Sachin Y. Paranjape, Bonnie K. Black, Connor Maxey, David C. Kem, Satish R. Raj
Publikováno v:
Journal of Translational Autoimmunity, Vol 2, Iss , Pp - (2019)
Background: Activating autoantibodies (AAb) to adrenergic receptors (AR) have previously been reported in patients with postural tachycardia syndrome (POTS). These AAb may contribute to a final common pathway for overlapping disease processes, reflec
Externí odkaz:
https://doaj.org/article/09ebaf1b5cb44593a243f29a23476a74
Autor:
Hongliang Li, Gege Zhang, Liping Zhou, Zachary Nuss, Marci Beel, Brendon Hines, Taylor Murphy, Jonathan Liles, Ling Zhang, David C. Kem, Xichun Yu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 19 (2019)
Background Previous studies have demonstrated that functional autoantibodies to adrenergic receptors may be involved in the pathogenesis of postural tachycardia syndrome. The objective of this study was to examine the impact of these autoantibodies o
Externí odkaz:
https://doaj.org/article/b1a50308e557406d9e55ef31578d07d8
Autor:
Xichun Yu, Hongliang Li, Taylor A. Murphy, Zachary Nuss, Jonathan Liles, Campbell Liles, Christopher E. Aston, Satish R. Raj, Artur Fedorowski, David C. Kem
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 8 (2018)
BackgroundBoth the adrenergic and renin‐angiotensin systems contribute to orthostatic circulatory homeostasis, which is impaired in postural orthostatic tachycardia syndrome (POTS). Activating autoantibodies to the α1‐adrenergic and β1/2‐adre
Externí odkaz:
https://doaj.org/article/b5b7b3f9080c4ce2b72924bea742c9cb
Autor:
Hongliang Li, Benjamin J. Scherlag, David C. Kem, Caitlin Zillner, Shailesh Male, Sorkko Thirunavukkarasu, Xiaohua Shen, Alexandria Benbrook, Jan V. Pitha, Ralph Lazzara, Xichun Yu
Publikováno v:
Journal of Aging Research, Vol 2014 (2014)
It is well established that atrial fibrillation (AF) is far more common in elderly humans. Autonomic activation is thought to be an operative mechanism for AF propensity. The aim of the study was to investigate the impact of age on atrial tachyarrhyt
Externí odkaz:
https://doaj.org/article/6bc511734ff743dfb3a3559cdf2c5c73
Autor:
Kenneth A. Mayuga, Artur Fedorowski, Fabrizio Ricci, Rakesh Gopinathannair, Jonathan Walter Dukes, Christopher Gibbons, Peter Hanna, Dan Sorajja, Mina Chung, David Benditt, Robert Sheldon, Mirna B. Ayache, Hiba AbouAssi, Kalyanam Shivkumar, Blair P. Grubb, Mohamed H. Hamdan, Stavros Stavrakis, Tamanna Singh, Jeffrey J. Goldberger, James A.S. Muldowney, Mark Belham, David C. Kem, Cem Akin, Barbara K. Bruce, Nicole E. Zahka, Qi Fu, Erik H. Van Iterson, Satish R. Raj, Fetnat Fouad-Tarazi, David S. Goldstein, Julian Stewart, Brian Olshansky
Publikováno v:
Circulation: Arrhythmia and Electrophysiology. 15
Sinus tachycardia (ST) is ubiquitous, but its presence outside of normal physiological triggers in otherwise healthy individuals remains a commonly encountered phenomenon in medical practice. In many cases, ST can be readily explained by a current me
Autor:
Heather R. Burks, Hongliang Li, LaTasha B. Craig, Xichun Yu, Elizabeth A. Weedin, David C. Kem, Christopher E. Aston
Publikováno v:
F&S Reports, Vol 1, Iss 3, Pp 299-304 (2020)
F&S Reports
F&S Reports
Objectives 1) To confirm the correlation of GnRH receptor (GnRHR) activating autoantibody (AAb) activity with polycystic ovary syndrome (PCOS) diagnosis in large well defined cohorts; and 2) to evaluate suppression of AAb activity with GnRH antagonis
Autor:
Xichun Yu, Hayley Fischer, Jielin Deng, Hongliang Li, Gege Zhang, Yankai Guo, David C. Kem, LaTasha B. Craig
Publikováno v:
Physiological Reports, Vol 8, Iss 24, Pp n/a-n/a (2021)
Physiological Reports
Physiological Reports
Polycystic ovary syndrome (PCOS), a metabolic and reproductive disease, is frequently associated with type 2 diabetes. We have demonstrated activating autoantibodies (AAb) directed toward the second extracellular loop (ECL2) of the gonadotropin‐rel
Autor:
Gege Zhang, Hongliang Li, David C. Kem, Yankai Guo, Hayley Fischer, Xichun Yu, Jielin Deng, LaTasha B. Craig
Publikováno v:
Experimental physiologyREFERENCES. 106(4)
New findings What is the central question of this study? Is there a causal relationship between gonadotrophin-releasing hormone (GnRH) receptor-activating autoantibodies and polycystic ovary syndrome (PCOS)? What is the main finding and its importanc