Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David C. Higgins"'
Autor:
David C. Higgins
Publikováno v:
Advanced Intelligent Systems, Vol 3, Iss 11, Pp n/a-n/a (2021)
Medical artificial intelligence (AI) involves the application of machine learning (ML) algorithms to biomedical datasets to improve medical practices. Products incorporating medical AI require certification before deployment in most jurisdictions. To
Externí odkaz:
https://doaj.org/article/ea7023db755c46c5a2849fadf82ab523
Autor:
Petko M. Petkov, Xiaosong Wang, David C. Higgins, Beverly Paigen, Peter M. Kelmenson, Kenneth Paigen
Publikováno v:
Genetics. 169:833-841
Within the 2.38-Mb Ath1 region of mouse chromosome 1, 42 of 45 genetic crossovers from crosses between C57BL/6J (B6) and either C3H/HeJ (H) or Mus spretus (SPRET) occurred in four zones (A–D); zone A, 100 kb long, contained a cluster of at least fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaafc5c56a73b3ccc9893173db3fdfc0
https://doi.org/10.1534/genetics.104.035063
https://doi.org/10.1534/genetics.104.035063
Autor:
Ramu Elango, Harry Whitmore, David C. Higgins, Stephen Harris, Jian-Long Mu, Beverly Paigen, Maureen K. Purcell
Publikováno v:
Mammalian Genome. 12:495-500
Ath6 is a novel quantitative trait locus associated with differences in susceptibility to atherosclerosis between C57BL/6J (B6) and C57BLKS/J (BKS) inbred mouse strains. Combining data from an intercross and a backcross (1593 meioses) between mice fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4414109097e7483cc6567221fa5a4d1f
https://doi.org/10.1007/s00335001-0006-9
https://doi.org/10.1007/s00335001-0006-9
Autor:
David C. Higgins, Benjamin A. Taylor, Beverly Paigen, Kira K. Lueders, Stephen B. Sampson, Robert A. Koza, Rosemary W. Elliot
Publikováno v:
Mammalian Genome. 9:688-694
We have updated the history of the AXB and BXA recombinant inbred (RI) strains, typed additional loci, and edited the AXB, BXA RI database. Thirteen of the original 51 AXB and BXA RI strains are either extinct or genetically contaminated, leaving 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce029b8b16efb2e9250e0af9a813bcfc
https://doi.org/10.1007/s003359900849
https://doi.org/10.1007/s003359900849
Autor:
David C. Higgins, Beverly Paigen
Publikováno v:
Mammalian Genome. 8:846-849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acae9beac42d00ba5d4d4a03c35add4
https://doi.org/10.1007/s003359900590
https://doi.org/10.1007/s003359900590
Autor:
Jacob Lagercrantz, Per Eriksson, Per Georg Olsson, Björn Wiman, Christina Petros, Jarod Rollins, Charlotte Wennberg, Massimiliano Ria, Xiaosong Wang, Naoto Ishii, Peter M. Kelmenson, Beverly Paigen, Ann Samnegård, Anna M. Bennet, Anders Hamsten, Kristina Forsman-Semb, Ulf de Faire, David C. Higgins, Kazuo Sugamura
Publikováno v:
Nature genetics. 37(4)
Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561c139caa2b2aaa7438fd875c843404
https://pubmed.ncbi.nlm.nih.gov/19029970
https://pubmed.ncbi.nlm.nih.gov/19029970
Identifying quantitative trait locus (QTL) genes is a challenging task. Herein, we report using a two-step process to identify Apoa2 as the gene underlying Hdlq5, a QTL for plasma high-density lipoprotein cholesterol (HDL) levels on mouse chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0967391faeae752843607c5a72eeb3e1
https://europepmc.org/articles/PMC515323/
https://europepmc.org/articles/PMC515323/
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 13(10)
Previously, we demonstrated that Ath1 is a quantitative trait locus for aortic fatty streak formation, located on Chromosome (chr) 1, with susceptibility in C57BL/6J mice and resistance in C3H/HeJ and BALB/cJ mice fed an atherogenic diet. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ec157797946b01792cdda8142a7e60
https://pubmed.ncbi.nlm.nih.gov/12420131
https://pubmed.ncbi.nlm.nih.gov/12420131
Autor:
Fumihiro Sugiyama, Gary A. Churchill, Haralambos Gavras, David C. Higgins, Beverly Paigen, Conrado Johns, Konstatinos P. Makaritsis
Publikováno v:
Genomics. 71(1)
To investigate the genetic control of salt-induced hypertension, we performed a quantitative trait locus analysis on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains after they we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90372aecb68138911e99f0739c23b761
https://pubmed.ncbi.nlm.nih.gov/11161799
https://pubmed.ncbi.nlm.nih.gov/11161799