Zobrazeno 1 - 10
of 283
pro vyhledávání: '"David C. Henshall"'
Autor:
Niraj Khemka, Gareth Morris, Laleh Kazemzadeh, Lara S. Costard, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Morten T. Venø, Jørgen Kjems, David C. Henshall, Jochen H. M. Prehn, Niamh M. C. Connolly
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive dysregulation of gene expression associated with epileptogenesis is shaped, in part, by mic
Externí odkaz:
https://doaj.org/article/aec36402be9d4848857dd99eb744d751
Autor:
Omar Mamad, Mona Heiland, Andreas U. Lindner, Thomas D. M. Hill, Ronan M. Ronroy, Kilian Rentrup, Amaya Sanz-Rodriguez, Elena Langa, Janosch P. Heller, Oscar Moreno, Jordi Llop, Anindya Bhattacharya, James A. Palmer, Marc Ceusters, Tobias Engel, David C. Henshall
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the P2X7 receptor antagonist JNJ-47
Externí odkaz:
https://doaj.org/article/4fa05e1ff28e4d35a32f692bc0e2ed81
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Autor:
Elizabeth Brindley, Mona Heiland, Catherine Mooney, Mairead Diviney, Omar Mamad, Thomas D. M. Hill, Yan Yan, Morten T. Venø, Cristina R. Reschke, Aasia Batool, Elena Langa, Amaya Sanz-Rodriguez, Janosch P. Heller, Gareth Morris, Karen Conboy, Jørgen Kjems, Gary P. Brennan, David C. Henshall
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels o
Externí odkaz:
https://doaj.org/article/5a12b88c05be4334969707b5a82ff1e7
Publikováno v:
IEEE Access, Vol 11, Pp 56494-56508 (2023)
The smart textile and wearables sector is looking towards advancing technologies to meet both industry, consumer and new emerging innovative textile application demands, within a fast paced textile industry. In parallel, inspiration based on the biol
Externí odkaz:
https://doaj.org/article/54c712bf5bde4f7facc981009b2cfc39
Autor:
Aoife Campbell, Gareth Morris, Albert Sanfeliu, Joana Augusto, Elena Langa, Jaideep C. Kesavan, Ngoc T. Nguyen, Ronan M. Conroy, Jesper Worm, Lukasz Kielpinski, Mads Aaboe Jensen, Meghan T. Miller, Thomas Kremer, Cristina R. Reschke, David C. Henshall
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 514-529 (2022)
Angelman syndrome (AS) is a severe neurodevelopmental disorder featuring ataxia, cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations or deletion of the maternal copy of the paternally imprinted UBE3A gene, with current precis
Externí odkaz:
https://doaj.org/article/9cfd00cc33fa406da3ff7352a705c687
Autor:
Chris Greene, Nicole Hanley, Cristina R. Reschke, Avril Reddy, Maarja A. Mäe, Ruairi Connolly, Claire Behan, Eoin O’Keeffe, Isobel Bolger, Natalie Hudson, Conor Delaney, Michael A. Farrell, Donncha F. O’Brien, Jane Cryan, Francesca M. Brett, Alan Beausang, Christer Betsholtz, David C. Henshall, Colin P. Doherty, Matthew Campbell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The mechanisms underlying epilepsy development are not well understood. Here the authors show that loss of a key component of the so called blood-brain barrier drives seizures in mice and is also lost in humans with treatment resistant epilepsy
Externí odkaz:
https://doaj.org/article/4e4b16153a6148c99d2bb1956b4675ce
Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice
Autor:
Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract MicroRNAs are short non-coding RNAs that negatively regulate protein levels and perform important roles in establishing and maintaining neuronal network function. Previous studies in adult rodents have detected upregulation of microRNA-134 a
Externí odkaz:
https://doaj.org/article/0b672bed99a647c39d8f5224165e8622
Autor:
Luiz F. Almeida Silva, Cristina R. Reschke, Ngoc T. Nguyen, Elena Langa, Amaya Sanz-Rodriguez, Rogerio R. Gerbatin, Fernanda R. Temp, Mayara L. de Freitas, Ronan M. Conroy, Gary P. Brennan, Tobias Engel, David C. Henshall
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense oligonucleotides indicate important roles for microRNAs during the development of epilepsy
Externí odkaz:
https://doaj.org/article/437cebdae0ed4f06ac210951c4c7a083
Autor:
Gareth Morris, Mona Heiland, Kai Lamottke, Haifeng Guan, Thomas D. M. Hill, Yijun Zhou, Qianjin Zhu, Stephanie Schorge, David C. Henshall
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
Drug-resistant epilepsy remains a significant clinical and societal burden, with one third of people with epilepsy continuing to experience seizures despite the availability of around 30 anti-seizure drugs (ASDs). Further, ASDs often have substantial
Externí odkaz:
https://doaj.org/article/74c315fdc0bd41c0a1cd0f3ffe2dfd61
Autor:
Catherine Mooney, Daragh O'Boyle, Mikael Finder, Boubou Hallberg, Brian H. Walsh, David C. Henshall, Geraldine B. Boylan, Deirdre M. Murray
Publikováno v:
Heliyon, Vol 7, Iss 7, Pp e07411- (2021)
Hypoxic Ischemic Encephalopathy (HIE) remains a major cause of neurological disability. Early intervention with therapeutic hypothermia improves outcome, but prediction of HIE is difficult and no single clinical marker is reliable. Machine learning a
Externí odkaz:
https://doaj.org/article/5dd71354e549427482db3e2035feff85