Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David C. Gondek"'
Publikováno v:
Artificial Intelligence. :93-105
This paper presents a vision for applying the Watson technology to health care and describes the steps needed to adapt and improve performance in a new domain. Specifically, it elaborates upon a vision for an evidence-based clinical decision support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565cf96a5e2f2357dbd298e53c096363
https://doi.org/10.1016/j.artint.2012.06.009
https://doi.org/10.1016/j.artint.2012.06.009
Publikováno v:
The Journal of Immunology. 189:2441-2449
Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Chlamydia infections that ascend to the upper genital tract can persist, trigger inflammation, and result in serious sequelae such as infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6db6f30d2ecd8786ed135ac819ee79c
https://doi.org/10.4049/jimmunol.1103032
https://doi.org/10.4049/jimmunol.1103032
Publikováno v:
Mucosal immunology
Chemokine receptors direct T lymphocytes to the site of an infection by following coordinated chemokine gradients, which allow their recruitment to specific tissues. Although identification of receptors needed for homing to some mucosal sites, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64791e9f903d00408742c45371e5d089
http://europepmc.org/articles/PMC3010299
http://europepmc.org/articles/PMC3010299
Publikováno v:
The Journal of Immunology. 183:1313-1319
Infection with the obligate intracellular bacterium Chlamydia trachomatis is controlled primarily by IFN-γ and Th1 immunity. In this study, we used cells from a Chlamydia-specific CD4+ TCR-transgenic mouse to assess the role of IFN-γ in development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86aedd0eb1e48c5453eef44b99fc42e
https://doi.org/10.4049/jimmunol.0900295
https://doi.org/10.4049/jimmunol.0900295
Autor:
Randolph J. Noelle, Elizabeth C. Nowak, Li-Fan Lu, Victor Devries, David C. Gondek, Kathryn A. Bennett, Zachary A. Scott
Publikováno v:
The Journal of Immunology. 181:4752-4760
Granzyme B (GZB) has been implicated as an effector mechanism in regulatory T cells (Treg) suppression. In a model of Treg-dependent graft tolerance, it is shown that GZB- deficient mice are unable to establish long-term tolerance. Moreover, mice ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c6036f2f6806fe478083335a84b98f
https://doi.org/10.4049/jimmunol.181.7.4752
https://doi.org/10.4049/jimmunol.181.7.4752
Autor:
David C. Gondek, Chong He, P. Jack Hoopes, Priyanka Agharkar, Curtis N Crane, Brian W. Pogue, Mark D. Savellano, Bin Chen
Publikováno v:
International Journal of Cancer. 123:695-701
Photodynamic therapy (PDT) is a light-based cancer treatment modality. Here we employed both in vivo and ex vivo fluorescence imaging to visualize vascular response and tumor cell survival after verteporfin-mediated PDT designed to target tumor vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::361d49bebfdcc9fafb1ad9f45463b906
https://doi.org/10.1002/ijc.23538
https://doi.org/10.1002/ijc.23538
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 5 (2015)
Frontiers in Cellular and Infection Microbiology, Vol 5 (2015)
Chlamydiae, obligate intracellular bacteria, cause significant human and veterinary associated diseases. Having emerged an estimated 700-million years ago, these bacteria have twice adapted to humans as a host species, causing sexually transmitted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2b251ff0b20d866122655077bc8128
Autor:
Omid C. Farokhzad, Mario Perro, Robert Langer, Jeremy Yethon, Andrew M. Tager, Andrew J. Olive, Pamela Basto, Aleksandar F. Radovic-Moreno, Vladimir Vrbanac, Michael N. Starnbach, Georg Stary, Ulrich H. von Andrian, David Alvarez, David C. Gondek, Jinjun Shi
Publikováno v:
Science (New York, N.Y.). 348(6241)
The right combination for protection Despite its prevalence, no vaccine exists to protect against infection with the sexually transmitted bacterium Chlamydia trachomatis . Stary et al. now report on one potential vaccine candidate (see the Perspectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9624759361c512c1cef5782801980b8
https://pubmed.ncbi.nlm.nih.gov/26089500
https://pubmed.ncbi.nlm.nih.gov/26089500
Autor:
Kathy A. Bennett, Randolph J. Noelle, Michael W Gleeson, Evan F. Lind, Xin Xiao Zheng, Li-Fan Lu, Anthony J. Coyle, Karina Pino-Lagos, Zachary A. Scott, Jacques Van Snick, David C. Gondek, Jennifer L. Reed, Terry B. Strom
Publikováno v:
Nature. 442:997-1002
Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained in this study establish that mast cells are essential in CD4(+)CD25(+)Foxp3(+) regulatory T (T-Reg)-cell-dependent peripheral tolerance. Here we confirm th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17561e6cd41cb68277f94f561364a7d9
https://doi.org/10.1038/nature05010
https://doi.org/10.1038/nature05010
Publikováno v:
The Journal of Immunology. 175:1651-1657
CD4+CD25+ regulatory T cells (Treg) play an important role in maintaining immunologic tolerance. Glucocorticoid-induced TNFR family-related gene (GITR) expressed preferentially at high levels on Treg has been shown to be a key player of regulating Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c6e4132d01047e80e27c6ef25ee4e7
https://doi.org/10.4049/jimmunol.175.3.1651
https://doi.org/10.4049/jimmunol.175.3.1651