Zobrazeno 1 - 10
of 71
pro vyhledávání: '"David C. Goldstone"'
Autor:
Derek Long, Liam Eade, Matthew P. Sullivan, Katharina Dost, Samuel M. Meier-Menches, David C. Goldstone, Christian G. Hartinger, Jörg S. Wicker, Katerina Taškova
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Mass spectrometry (MS) is an analytical technique for molecule identification that can be used for investigating protein-metal complex interactions. Once the MS data is collected, the mass spectra are usually interpreted manually to identify
Externí odkaz:
https://doaj.org/article/4b0d56182a504a0c8b7b8f6d706ad956
Autor:
Bin Lin, Smitha Nair, Daniel M. J. Fellner, Noha Ahmed Nasef, Harjinder Singh, Leonardo Negron, David C. Goldstone, Margaret A. Brimble, Juliet A. Gerrard, Laura Domigan, Jackie C. Evans, Jonathan M. Stephens, Troy L. Merry, Kerry M. Loomes
Publikováno v:
Foods, Vol 12, Iss 22, p 4072 (2023)
3,6,7-trimethyllumazine (Lepteridine™) is a newly discovered natural pteridine derivative unique to Mānuka (Leptospermum scoparium) nectar and honey, with no previously reported biological activity. Pteridine derivative-based medicines, such as me
Externí odkaz:
https://doaj.org/article/7474211470de49f6811314d0746139e9
Autor:
Michael R. Oliver, Christopher R. Horne, Safal Shrestha, Jeremy R. Keown, Lung-Yu Liang, Samuel N. Young, Jarrod J. Sandow, Andrew I. Webb, David C. Goldstone, Isabelle S. Lucet, Natarajan Kannan, Peter Metcalf, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The viral Protein Kinase-1 (PK-1) phosphorylates the regulatory protein p6.9, which facilitates baculoviral genome release. Here, the authors combine X-ray crystallography with biophysical and biochemical analyses as well as molecular dynamics simula
Externí odkaz:
https://doaj.org/article/68962591ebc346e3865840990c4f686b
Autor:
Oliver Acton, Tim Grant, Giuseppe Nicastro, Neil J. Ball, David C. Goldstone, Laura E. Robertson, Kasim Sader, Andrea Nans, Andres Ramos, Jonathan P. Stoye, Ian A. Taylor, Peter B. Rosenthal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
In retroviruses, the capsid protein (CA) forms a shell surrounding the viral core. Here the authors combine cryo-electron microscopy with NMR and X-ray crystallography to examine the CA structure from the human endogenous retrovirus HML2 (HERV-K) and
Externí odkaz:
https://doaj.org/article/50d5434d21c24069a587937d07c9ffa6
Autor:
Melissa N. Webby, Nicole Herr, Esther M. M. Bulloch, Michael Schmitz, Jeremy R. Keown, David C. Goldstone, Richard L. Kingston
Publikováno v:
Viruses, Vol 13, Iss 9, p 1737 (2021)
The paramyxoviral phosphoprotein (P protein) is the non-catalytic subunit of the viral RNA polymerase, and coordinates many of the molecular interactions required for RNA synthesis. All paramyxoviral P proteins oligomerize via a centrally located coi
Externí odkaz:
https://doaj.org/article/fb1fa7aa7a7d4673b947e3430ec172ed
Autor:
Jully Pinheiro, Jacob Biboy, Waldemar Vollmer, Robert P. Hirt, Jeremy R. Keown, Anastasiia Artuyants, Moyra M. Black, David C. Goldstone, Augusto Simoes-Barbosa
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT The human eukaryotic pathogen Trichomonas vaginalis causes trichomoniasis, a prevalent sexually transmitted infection. This extracellular protozoan is intimately associated with the human vaginal mucosa and microbiota, but key aspects of the
Externí odkaz:
https://doaj.org/article/50cdd0bb39a84233aa8ccce089feea7f
Autor:
Matthew P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. Herbert, Kelvin K. H. Tong, Jonathan W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. Goldstone, Christian G. Hartinger
Publikováno v:
Dalton Transactions. 52:1388-1392
Substitution of a labile Cl− for an NHC ligand in DNA-intercalating [Pt(terpyridine)]+ complexes improved the cytotoxicity and cellular accumulation, while in vivo studies indicated good tolerability in zebrafish.
Autor:
Mauren Jaudal, Matthew Mayo‐Smith, Axel Poulet, Annabel Whibley, Yongyan Peng, Lulu Zhang, Geoffrey Thomson, Laura Trimborn, Yannick Jacob, Josien C. van Wolfswinkel, David C. Goldstone, Jiangqi Wen, Kirankumar S. Mysore, Joanna Putterill
Publikováno v:
The Plant Journal. 112:1029-1050
Autor:
Matthew P. Sullivan, Ena Yano, Betty Y. T. Lee, David C. Goldstone, Stephen M. F. Jamieson, Tilo Soehnel, Muhammad Hanif, Christian G. Hartinger, Kelvin K. H. Tong, Tomoyo Kawakubo-Yasukochi
Publikováno v:
Inorganic Chemistry. 60:14636-14644
N-Heterocyclic carbene (NHC) ligands are widely investigated in medicinal inorganic chemistry. Here, we report the preparation and characterization of a series of half-sandwich [M(L)(NHC)Cl2] (M = Ru, Os, Rh, Ir; L = cym/Cp*) complexes with a N-flank
Autor:
Mauren, Jaudal, Matthew, Mayo-Smith, Axel, Poulet, Annabel, Whibley, Yongyan, Peng, Lulu, Zhang, Geoffrey, Thomson, Laura, Trimborn, Yannick, Jacob, Josien C, van Wolfswinkel, David C, Goldstone, Jiangqi, Wen, Kirankumar S, Mysore, Joanna, Putterill
Publikováno v:
The Plant journal : for cell and molecular biologyReferences. 112(4)
Flowering of the reference legume Medicago truncatula is promoted by winter cold (vernalization) followed by long-day photoperiods (VLD) similar to winter annual Arabidopsis. However, Medicago lacks FLC and CO, key regulators of Arabidopsis VLD flowe