Zobrazeno 1 - 10
of 65
pro vyhledávání: '"David C. Gale"'
Autor:
Esaie Pierre, Scott J Robbie, Peter Adamson, Achim Hans-Peter Krauss, Meihua Ju, Kanako Izumi-Nagai, David T. Shima, David C. Gale, Yin-Shan Ng, James W B Bainbridge, Nori Nagai
Publikováno v:
The American Journal of Pathology. 185:2534-2549
Choroidal neovascularization (CNV) is a defining feature of wet age-related macular degeneration. We examined the functional role of CCR3 in the development of CNV in mice and primates. CCR3 was associated with spontaneous CNV lesions in the newly de
Autor:
Michael J. Young, David C. Gale, Burke Lieppman, Hong Lin, Petr Baranov, Dwight M. Morrow, Justin Liao, Kathryn L. Mccabe, Phoebe Lei, Shenshen Cai
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 33(5)
Degenerative diseases of the retina, such as retinitis pigmentosa and age-related macular degeneration, are characterized by the irreversible loss of photoreceptors. Several growth factors, including glial cell derived neurotrophic factor (GDNF), hav
Autor:
Peter Adamson, Patric Turowski, Bridget-Ann Kenny, Paul Canning, Mosharraf H. Sarker, Natalie Hudson, J. V. Glenn, Francisco J. López, Vivien E. Prise, Philip J. Luthert, Martin Brandt, David C. Gale, Alan W. Stitt
Publikováno v:
Canning, P, Kenny, B-A, Prise, V, Glenn, J, Sarker, M H, Hudson, N, Brandt, M, Lopez, F J, Gale, D, Luthert, P J, Adamson, P, Turowski, P & Stitt, A W 2016, ' Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 26, pp. 7213-7218 . https://doi.org/10.1073/pnas.1514213113
Lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyses oxidized low-density lipoproteins into proinflammatory products, which can have detrimental effects on vascular function. As a specific inhibitor of Lp-PLA2, darapladib has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40881755e4db71e700b1c1fd403780a4
https://pure.qub.ac.uk/en/publications/lipoproteinassociated-phospholipase-a2-lppla2-as-a-therapeutic-target-to-prevent-retinal-vasopermeability-during-diabetes(95f64b03-626d-417a-b17f-46a9829e022e).html
https://pure.qub.ac.uk/en/publications/lipoproteinassociated-phospholipase-a2-lppla2-as-a-therapeutic-target-to-prevent-retinal-vasopermeability-during-diabetes(95f64b03-626d-417a-b17f-46a9829e022e).html
Autor:
Walter A. Shaw, David C. Gale, Luiz A. Peregrino-Ferreira, W E Morrill, Victoria Pope, Maria Luiza Bazzo, Mahin M. Park, Arnold R. Castro
Publikováno v:
Clinical Diagnostic Laboratory Immunology. 7:658-661
The Venereal Disease Research Laboratory (VDRL) test is a microflocculation test for syphilis that uses an antigen containing cardiolipin, lecithin, and cholesterol. For more than 50 years, the preparation of natural cardiolipin and lecithin for this
Publikováno v:
Journal of Mass Spectrometry. 30:1095-1102
The relative non-covalent binding behavior of two small molecule ligands to the tetrameric protein streptavidin was investigated by electrospray ionization mass spectrometry (ESI-MS). An extended m/z range quadrupole mass spectrometer was employed to
Publikováno v:
Analytical Chemistry. 67:1477-1480
The combination of capillary electrophoresis (CE) with electrospray ionization (ESI) mass spectrometry has proven to be broadly applicable to a wide range of biologically important compounds. When combined with Fourier transform ion cyclotron resonan
Publikováno v:
Optical Materials. 4:455-460
Nonlinear optical properties of transition metal-phosphine complexes have been measured at 532 nm by degenerate four-wave mixing. Large nonresonant second-order molecular hyperpolarizabilities, γ, have been found for complexes containing two phosphi
Publikováno v:
Analytical Chemistry. 67:586-593
We have investigated the feasibility of simplifying the electrospray ionization (ESI) mass spectra for mixture analyses through charge state reduction. Two methods for charge state reduction of gas phase oligonucleotide negative ions were evaluated:
Publikováno v:
Journal of Chromatography A. 659:217-222
The analyses of tryptic digest of proteins present a difficult challenge to the analytical chemist due to the wide range of molecular masses and hydrophobicities of the peptides produced. In this study, we demonstrate the separation of tryptic digest
Publikováno v:
Review of Scientific Instruments. 64:3072-3075
A degenerate‐four‐wave‐mixing apparatus is described, with novel data acquisition, and sample handling techniques. Particular attention is paid to methods of noise reduction and elimination. Four‐wave mixing is performed with Nd:YAG laser lig