Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David C. Cipolla"'
Autor:
Vivien R. Sutton, Sally V. Watt, Hedieh Akhlaghi, David C. Cipolla, Kuan-Ju Chen, Daniel LaSala, Patrick P. McDonald, Paul A. Beavis, Isabelle Munoz, Adrian W. Hodel, Tahereh Noori, Ilia Voskoboinik, Joseph A. Trapani
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Recently developed small-molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of neutrophil s
Externí odkaz:
https://doaj.org/article/637ceae3f9ef4a27add5a0ac7f8e1bc1
Autor:
Patrick P. McDonald, Franziska Graf Leifer, Jessica Basso, Dan Lasala, Dedong Li, Kuan-Ju Chen, Jimin Zhang, Walter R. Perkins, David C. Cipolla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rheumatoid arthritis (RA) is a painful and incurable disease characterized by chronic joint inflammation and a progressive destruction of cartilage and bone. Although current treatments have improved clinical outcomes for some patients, the high rela
Externí odkaz:
https://doaj.org/article/8bdd637f3aad40d9abb74d1bb722c196
Autor:
Jessica Basso, Kuan-Ju Chen, Yuchen Zhou, Lilly Mark, Daniel LaSala, Arielle Dorfman, Mary Atalla, Donald Chun, Veronica Viramontes, Christina Chang, Franziska Leifer, Patrick P. McDonald, David C. Cipolla
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Brensocatib is a novel, oral, selective, reversible inhibitor of dipeptidyl peptidase 1 (DPP1), which activates several neutrophil serine proteases (NSPs), including neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in the bone mar
Externí odkaz:
https://doaj.org/article/a26331d5dd3f4103b5293969b4ae00de
Autor:
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins, David C. Cipolla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neutrophils have been implicated in initiating and perpetuating systemic lupus erythematosus and the resultant kidney damage in lupus nephritis (LN) patients, in part through an excessive release of neutrophil serine proteases (NSPs). NSP zymogens ar
Externí odkaz:
https://doaj.org/article/39068ea155094654afda96d63a8b6583
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 302 (2022)
While the inhalation route has been used for millennia for pharmacologic effect, the biological barriers to treating lung disease created real challenges for the pharmaceutical industry until sophisticated device and formulation technologies emerged
Externí odkaz:
https://doaj.org/article/caf4b876b6df4a879758e69fa018fc83