Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David C. Butler"'
Autor:
Anne Messer, David C. Butler
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Intrabodies (both single-chain Fv and single-domain VH, VHH, and VL nanobodies) offer unique solutions to some of the challenges of delivery and target engagement posed by immunotherapeutics for the brain and other areas of the nervous system. The sp
Externí odkaz:
https://doaj.org/article/2400f80253504e448de7821f4f98ebbe
Autor:
David C Butler, Anne Messer
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29199 (2011)
Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a trinucleotide (CAG)(n) repeat expansion in the coding sequence of the huntingtin gene, and an expanded polyglutamine (>37Q) tract in the protein. This resu
Externí odkaz:
https://doaj.org/article/270f40cfc1294554b408fd78d81a4796
Autor:
Ameena Hajira, Junaith S. Mohamed, David C. Butler, Stephen E. Alway, David A. Stanton, Satoshi Haramizu, Shinichi Asano
Publikováno v:
The Journal of Nutritional Biochemistry. 50:103-115
High levels of reactive oxygen species (ROS) contributes to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ded6f2d69f6cc14e01fae6449c1663a
https://doi.org/10.1016/j.jnutbio.2017.08.008
https://doi.org/10.1016/j.jnutbio.2017.08.008
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6302 (2009)
Inhibitor of differentiation protein-2 (Id2) is a dominant negative helix-loop-helix (HLH) protein, and a positive regulator of proliferation, in various cells. The N-terminal region of Id2 contains a consensus cdk2 phosphorylation sequence SPVR, whi
Externí odkaz:
https://doaj.org/article/8f1db064f66041c296181d7c63672129
Publikováno v:
mAbs. 4:686-693
Intrabodies can be powerful reagents to effect modulation of aberrant intracellular proteins that underlie a range of diseases. However, their cytoplasmic solubility can be limiting. We previously reported that overall charge and hydrophilicity can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68e4db0eddf8dacf4bad2114298e1d6
https://doi.org/10.4161/mabs.21696
https://doi.org/10.4161/mabs.21696
Publikováno v:
Progress in Neurobiology. 97:190-204
The engineered antibody approach to Huntington's disease (HD) therapeutics is based on the premise that significantly lowering the levels of the primary misfolded mutant protein will reduce abnormal protein interactions and direct toxic effects of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a20e827d0bcf70119e6b266cffd75b
https://doi.org/10.1016/j.pneurobio.2011.11.004
https://doi.org/10.1016/j.pneurobio.2011.11.004
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 297:E304-E314
Elevated phosphorylation of AMP-activated protein kinase (AMPK) has been shown to inhibit skeletal muscle growth in both culture and animal models, but its role in differentiation of muscle cells is less clear. p21 is known to have an important role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19313e626220c7c8963112a50658b953
https://doi.org/10.1152/ajpendo.91007.2008
https://doi.org/10.1152/ajpendo.91007.2008
Publikováno v:
American Journal of Physiology-Cell Physiology. 288:C338-C349
The influence of aging on skeletal myocyte apoptosis is not well understood. In this study we examined apoptosis and apoptotic regulatory factor responses to muscle atrophy induced via limb unloading following loading-induced hypertrophy. Muscle hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec4b2848f6e17a20952f815811857a5
https://doi.org/10.1152/ajpcell.00239.2004
https://doi.org/10.1152/ajpcell.00239.2004
Autor:
David C. Butler, Indranil Biswas
Publikováno v:
Communications in Algebra. 33:323-330
Let π:C → B be a (possibly ramified) covering map between smooth curves over an algebraically closed field with the genus of B being at least two. A question due to David Prill asks whether h 0(X, 𝒪 C (π−1(b))) = 1 for the general closed poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15595130eab13b75000f7f1f19be0492
https://doi.org/10.1081/agb-200041017
https://doi.org/10.1081/agb-200041017
Autor:
David C. Butler
Publikováno v:
Mathematische Zeitschrift. 231:397-407
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e813fc691b3d72c9d870f5d0254c40
https://doi.org/10.1007/pl00004739
https://doi.org/10.1007/pl00004739