Zobrazeno 1 - 10
of 61
pro vyhledávání: '"David C. Bulmer"'
Autor:
Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodo
Externí odkaz:
https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e965989
Autor:
Toni S. Taylor, Parvesh Konda, Sarah S. John, David C. Bulmer, James R. F. Hockley, Ewan St. John Smith
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the a
Externí odkaz:
https://doaj.org/article/43d932d5034d41e1a77ebd1e7b62ce9e
Autor:
Katie H. Barker, James P. Higham, Luke A. Pattison, Iain P. Chessell, Fraser Welsh, Ewan St. J. Smith, David C. Bulmer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G250-G261
The pro-inflammatory cytokine interleukin-13 (IL-13) is elevated in gastrointestinal (GI) diseases. This study confirms a role for IL-13 in colonic afferent sensitization and defines a role for downstream Janus kinase (JAK) and p38 MAPK signaling in
Autor:
James M. Collins, Niall P. Hyland, Gerard Clarke, Patrick Fitzgerald, Marcela Julio‐Pieper, David C. Bulmer, Timothy G. Dinan, John F. Cryan, Siobhain M. O'Mahony
Publikováno v:
Journal of Neurochemistry.
Publikováno v:
Visceral Pain ISBN: 9783031257018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08dd23724ea29919be49fc518cd1fa08
https://doi.org/10.1007/978-3-031-25702-5_8
https://doi.org/10.1007/978-3-031-25702-5_8
Autor:
Kazuya Takahashi, David C. Bulmer, Madusha Peiris, Shuji Terai, Qasim Aziz, Jocelyn Rachel Schreyer, Iman Geelani Khwaja
Publikováno v:
Crohn's & Colitis 360. 3
Patients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain–gut axis, such as peripheral and central sensitization, altered sympatho-vagal
Autor:
Zoe Hore, David C. Bulmer, Ewan St. John Smith, Sylvine Lalnunhlimi, Leonie S. Taams, Charity N. Bhebhe, Franziska Denk, Sampurna Chakrabarti, Luke A. Pattison, Gerard Callejo
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Fibroblast-like synoviocytes (FLS) interact with articular sensory nerve endings. Coculture of tumor necrosis factor (TNF-α)-stimulated FLS and knee-innervating sensory neurons reveals FLS-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf08cd7733632e2a8dfd160ca7b0f24a
Autor:
Ewan St. John Smith, Parvesh Konda, David C. Bulmer, James R.F. Hockley, Toni S Taylor, Sarah John
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Physiological Reports
Physiological Reports
Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the actions of
Autor:
Katie H Barker, Gerard Callejo, Toni S Taylor, James R.F. Hockley, Zoé Husson, Ewan St. John Smith, David C. Bulmer
Publikováno v:
Molecular Pain
Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to visceral hype
Autor:
David C. Bulmer, Harween Dogra, Cian McGuire, Abi Belai, Michael M Tranter, Wendy J. Winchester, Eduardo José de Almeida Araújo, L. Ashley Blackshaw, James R.F. Hockley, Gareth J. Sanger, Vincent Cibert-Goton, Charles H. Knowles, Victor W S Kung
Publikováno v:
Pain. 161(4)
The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse