Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David C. Browe"'
Autor:
David C. Browe, Ross Burdis, Pedro J. Díaz-Payno, Fiona E. Freeman, Jessica M. Nulty, Conor T. Buckley, Pieter A.J. Brama, Daniel J. Kelly
Publikováno v:
Materials Today Bio, Vol 16, Iss , Pp 100343- (2022)
Articular cartilage defects fail to heal spontaneously, typically progressing to osteoarthritis. Bone marrow stimulation techniques such as microfracture (MFX) are the current surgical standard of care; however MFX typically produces an inferior fibr
Externí odkaz:
https://doaj.org/article/87c2e54468a044dcbcd11fc8165ed03b
Autor:
Fiona E. Freeman, Meadhbh Á. Brennan, David C. Browe, Audrey Renaud, Julien De Lima, Daniel J. Kelly, Laoise M. McNamara, Pierre Layrolle
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
There is a distinct clinical need for new therapies that provide an effective treatment for large bone defect repair. Herein we describe a developmental approach, whereby constructs are primed to mimic certain aspects of bone formation that occur dur
Externí odkaz:
https://doaj.org/article/bf0e78b1e8b84b379f0b53a4593a193d
Autor:
Pedro J. Díaz-Payno, David C. Browe, Fiona E. Freeman, Jessica Nulty, Ross Burdis, Daniel J. Kelly
Publikováno v:
Tissue Engineering Part A. 28:724-736
Autor:
David C. Browe, Pedro J. Díaz-Payno, Fiona E. Freeman, Rossana Schipani, Ross Burdis, Daniel P. Ahern, Jessica M. Nulty, Selcan Guler, Lindsey D. Randall, Conor T. Buckley, Pieter A.J. Brama, Daniel J. Kelly
Publikováno v:
Acta Biomaterialia. 143:266-281
While some clinical advances in cartilage repair have occurred, osteochondral (OC) defect repair remains a significant challenge, with current scaffold-based approaches failing to recapitulate the complex, hierarchical structure of native articular c
Autor:
Jessica Nulty, Pedro J. Díaz-Payno, Daniel J. Kelly, Fiona E. Freeman, Bin Wang, David C. Browe, Ross Burdis
Publikováno v:
Acta Biomaterialia. 128:130-142
3D bioprinting has emerged as a promising technology in the field of tissue engineering and regenerative medicine due to its ability to create anatomically complex tissue substitutes. However, it still remains challenging to develop bioactive bioinks
Autor:
Daniel P. Ahern, Fiona E. Freeman, Pierluca Pitacco, Eben Alsberg, Yu Bin Lee, Ross Burdis, Daniel J. Kelly, Jessica Nulty, David C. Browe
Publikováno v:
Acta Biomaterialia. 126:154-169
For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective prevascularisation strategies are required to provide the necessary nutrients for normal metabolism and to remove associated waste by-products. The aim of this study wa
Publikováno v:
Biochemical and Biophysical Research Communications
Tissue-specific extracellular matrix (ECM) proteins can play a key role in regulating the fate of stem cells and can potentially be utilized for therapeutic applications. Realising this potential requires further characterization of the diversity of
Autor:
Warren L. Grayson, Daniel J. Kelly, Fiona E. Freeman, S. Von Euw, David C. Browe, Jessica Nulty
Publikováno v:
European Cells & Materials, Vol 38, Pp 168-187 (2019)
European Cells and Materials
European Cells and Materials
Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell migration, vascularisation and diffusion of nutrients and regulatory molecules inside the scaffold. 3D printing is a promising strategy to achieve this as
Autor:
Ross Burdis, Farhad Chariyev-Prinz, David C. Browe, Fiona E. Freeman, Jessica Nulty, Emily E. McDonnell, Kian F. Eichholz, Bin Wang, Pieter Brama, Daniel J. Kelly
Publikováno v:
Biomaterials. 289:121750
Modular biofabrication strategies using microtissues or organoids as biological building blocks have great potential for engineering replacement tissues and organs at scale. Here we describe the development of a biofabrication strategy to engineer os
Autor:
Kian F Eichholz, Fiona E Freeman, Pierluca Pitacco, Jessica Nulty, Daniel Ahern, Ross Burdis, David C Browe, Orquidea Garcia, David A Hoey, Daniel J Kelly
Publikováno v:
Biofabrication. 14:045013
Emerging 3D printing technologies can provide exquisite control over the external shape and internal architecture of scaffolds and tissue engineering (TE) constructs, enabling systematic studies to explore how geometric design features influence the