Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David C. Briggs"'
Autor:
Douglas Sammon, Anja Krueger, Marta Busse-Wicher, Rhodri Marc Morgan, Stuart M. Haslam, Benjamin Schumann, David C. Briggs, Erhard Hohenester
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS), control many aspects of development and physiology in a type-specific manner. HS and CS are attached to core proteins via a common linker tetrasaccharide,
Externí odkaz:
https://doaj.org/article/e93e6f683e98463789b2743a15c05db5
Autor:
Morgan Jones, Fabienne Beuron, Aaron Borg, Andrea Nans, Christopher P. Earl, David C. Briggs, Ambrosius P. Snijders, Maureen Bowles, Edward P. Morris, Mark Linch, Neil Q. McDonald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The endonuclease XPF-ERCC1 is a key component of the repair machinery to process both intra-strand and inter-strand DNA crosslinks. Here the authors present the cryo-EM structures of DNA-free and DNA-bound human XPF-ERCC1 and find that DNA-free XPF-E
Externí odkaz:
https://doaj.org/article/92077ba79c5f4633a25574477d6776b9
Autor:
Lingtian Zhang, Marialuisa Moccia, David C. Briggs, Jaideep B. Bharate, Naga Rajiv Lakkaniga, Phillip Knowles, Wei Yan, Phuc Tran, Anupreet Kharbanda, Xiuqi Wang, Yuet-Kin Leung, Brendan Frett, Massimo Santoro, Neil Q. McDonald, Francesca Carlomagno, Hong-yu Li
Publikováno v:
Journal of Medicinal Chemistry. 65:1536-1551
Mutations of the rearranged during transfection (RET) kinase are frequently reported in cancer, which make it as an attractive therapeutic target. Herein, we discovered a series of N-trisubstituted pyrimidine derivatives as potent inhibitors for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de99c59f8ad8a17aa62c446b5f5bf21
https://doi.org/10.1021/acs.jmedchem.1c01280
https://doi.org/10.1021/acs.jmedchem.1c01280
Autor:
Marjoke F, Debets, Omur Y, Tastan, Simon P, Wisnovsky, Stacy A, Malaker, Nikolaos, Angelis, Leonhard K R, Moeckl, Junwon, Choi, Helen, Flynn, Lauren J S, Wagner, Ganka, Bineva-Todd, Aristotelis, Antonopoulos, Anna, Cioce, William M, Browne, Zhen, Li, David C, Briggs, Holly L, Douglas, Gaelen T, Hess, Anthony J, Agbay, Chloe, Roustan, Svend, Kjaer, Stuart M, Haslam, Ambrosius P, Snijders, Michael C, Bassik, W E, Moerner, Vivian S W, Li, Carolyn R, Bertozzi, Benjamin, Schumann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Most human secreted and cell surface proteins are modified by Ser/Thr(O)-linked glycosylation with N-acetylgalactosamine (O-GalNAc). While of fundamental importance in health and disease, O-GalNAcglycosylation is technically challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a0a79b1e532c559b79dbba6e19e0a6a
https://pubmed.ncbi.nlm.nih.gov/32989128
https://pubmed.ncbi.nlm.nih.gov/32989128
Autor:
Antonio Inforzato, Clair Baldock, Thomas A. Jowitt, David F. Holmes, Ragnar Lindstedt, Marcella Marcellini, Vincenzo Rivieccio, David C. Briggs, Karl E. Kadler, Antonio Verdoliva, Barbara Bottazzi, Alberto Mantovani, Giovanni Salvatori, Anthony J. Day
Publikováno v:
Journal of Biological Chemistry. 295:1768
The inflammation-associated long pentraxin PTX3 plays key roles in innate immunity, female fertility, and vascular biology (e.g. it inhibits FGF2 (fibroblast growth factor 2)-mediated angiogenesis). PTX3 is composed of multiple protomers, each compos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b501e6a402a5c1199fd79be16b940e2
https://doi.org/10.1074/jbc.aac120.012568
https://doi.org/10.1074/jbc.aac120.012568
Autor:
Natalia S, Baranova, Simon J, Foulcer, David C, Briggs, Viranga, Tilakaratna, Jan J, Enghild, Caroline M, Milner, Anthony J, Day, Ralf P, Richter
Publikováno v:
The Journal of Biological Chemistry
Background: Inflammation/ovulation-associated protein TSG-6 performs multiple functions in hyaluronan (HA)-rich extracellular matrices. Results: Inter-α-inhibitor (IαI) affects HA-TSG-6 interactions and enhancement of cell adhesion while promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::040a51d1f160e9b6d63d9c3ae5790b7f
https://pubmed.ncbi.nlm.nih.gov/24005673
https://pubmed.ncbi.nlm.nih.gov/24005673
Autor:
David P. Lowe, Mark A. Cook, Simon J. Bowman, David C. Briggs, the UK Sjögrens Interest Group
Publikováno v:
Rheumatology; Apr2009, Vol. 48 Issue 4, p359-359, 1p
Conference
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