Zobrazeno 1 - 10
of 80
pro vyhledávání: '"David C. Amberg"'
Autor:
Brian K. Haarer, Morgan L. Pimm, Ebbing P. de Jong, David C. Amberg, Jessica L. Henty-Ridilla
Publikováno v:
Journal of Cell Science. 136
Biochemical studies of human actin and its binding partners rely heavily on abundant and easily purified α-actin from skeletal muscle. Therefore, muscle actin has been used to evaluate and determine the activities of most actin regulatory proteins b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1305ec0f22bbf29b65819718432fe72
https://doi.org/10.1242/jcs.260540
https://doi.org/10.1242/jcs.260540
Autor:
Richard C Silva, Martina Dautel, Bruno M Di Genova, David C Amberg, Beatriz A Castilho, Evelyn Sattlegger
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131070 (2015)
The Saccharomyces cerevisiae protein Yih1, when overexpressed, inhibits the eIF2 alpha kinase Gcn2 by competing for Gcn1 binding. However, deletion of YIH1 has no detectable effect on Gcn2 activity, suggesting that Yih1 is not a general inhibitor of
Externí odkaz:
https://doaj.org/article/0596328631ed47d090dc88db2982f095
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002288 (2011)
Saccharomyces cerevisiae has been a powerful model for uncovering the landscape of binary gene interactions through whole-genome screening. Complex heterozygous interactions are potentially important to human genetic disease as loss-of-function allel
Externí odkaz:
https://doaj.org/article/a7e18532db19458094f45ddb2b1432de
Autor:
Stephanie N. Diprima, Susan Viggiano, David C. Amberg, Chad L. Myers, Carles Pons, Brian Haarer
Publikováno v:
G3: Genes|Genomes|Genetics
Previous genome-level genetic interaction screens with the single essential actin gene of yeast identified 238 nonessential genes that upon deletion result in deleterious, digenic complex haploinsufficiences with an actin null allele. Deletion allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7aeae8e92788702955cde25844c152
https://doi.org/10.1534/g3.114.012054
https://doi.org/10.1534/g3.114.012054
Autor:
David C. Amberg, Dimitra Aggeli, Erik Kish-Trier, John A. Cooper, Gino Cingolani, Meng Chi Lin, Brian Haarer, Stephan Wilkens
Publikováno v:
Cytoskeleton. 71:361-379
Cofilin is a ubiquitous modulator of actin cytoskeleton dynamics that can both stabilize and destabilize actin filaments depending on its concentration and/or the presence of regulatory co-factors. Three charge-reversal mutants of yeast cofilin, loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d63b5997706234cb9cf846e9608c1bf
https://doi.org/10.1002/cm.21178
https://doi.org/10.1002/cm.21178
Autor:
Lei Mi-Mi, Susan Viggiano, Matthew Cortese, David C. Amberg, Brian Haarer, Daniel J. Burke, Jessica Cho
Publikováno v:
G3: Genes|Genomes|Genetics
The actin cytoskeleton exists in a dynamic equilibrium with monomeric and filamentous states of its subunit protein actin. The spatial and temporal regulation of actin dynamics is critical to the many functions of actin. Actin levels are remarkably c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42817306504aa69b1b8e2042b2e36925
http://europepmc.org/articles/PMC3583461
http://europepmc.org/articles/PMC3583461
Publikováno v:
Cytoskeleton. 68:340-354
Actin oxidation is known to result in changes in cytoskeleton organization and dynamics. Actin oxidation is clinically relevant since it occurs in the erythrocytes of sickle cell patients and may be the direct cause of the lack of morphological plast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfd5de019c5f4d1f2a3343cd6d037f4
https://doi.org/10.1002/cm.20516
https://doi.org/10.1002/cm.20516
Autor:
John J. Scarcelli, David C. Amberg, Catherine V. Heath, Charles N. Cole, Christine A. Hodge, Susan Viggiano
Publikováno v:
Genetics. 179:1945-1955
Coordination of the multiple steps of mRNA biogenesis helps to ensure proper regulation of gene expression. The Saccharomyces cerevisiae DEAD-box protein Rat8p/Dbp5p is an essential mRNA export factor that functions at the nuclear pore complex (NPC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728858a4060e65ead45232116f881843
https://doi.org/10.1534/genetics.108.091256
https://doi.org/10.1534/genetics.108.091256
Autor:
David C. Amberg, Michael G. Clark
Publikováno v:
Genetics. 176:1527-1539
Explication of the Aip1p/cofilin/actin filament complex may lead to a more detailed understanding of the mechanisms by which Aip1p and cofilin collaborate to rapidly disassemble filaments. We further characterized the actin–Aip1p interface through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82a09dc1cc2d6aeb31af30ed72cd369
https://doi.org/10.1534/genetics.107.072066
https://doi.org/10.1534/genetics.107.072066
Publikováno v:
Eukaryotic Cell. 6:797-807
Faithful partitioning of genetic material during cell division requires accurate spatial and temporal positioning of nuclei within dividing cells. In Saccharomyces cerevisiae , nuclear positioning is regulated by an elegant interplay between componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c4680d03c7d94b5c2fd24d5bea28ba
https://doi.org/10.1128/ec.00332-06
https://doi.org/10.1128/ec.00332-06