Výsledky vyhledávání - "David C. Ackley"

Effects of Di-2-Ethylhexyl Phthalate (DEHP) on Gap-Junctional Intercellular Communication (GJIC), DNA Synthesis, and Peroxisomal Beta Oxidation (PBOX) in Rat, Mouse, and Hamster Liver

Autor: Jacqueline H. Smith, Arthur W. Lington, James E. Klaunig, Jason S. Isenberg, George Pugh, Lisa M. Kamendulis, David C. Ackley

Publikováno v: Toxicological Sciences. 56:73-85

The present study evaluated the effect of di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX) activity, and replicative DNA synthesis in several rodent species with differing suscep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351d052541249bfd2e6181dc48c75519
https://doi.org/10.1093/toxsci/56.1.73

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Effects of Di-isononyl Phthalate, Di-2-ethylhexyl Phthalate, and Clofibrate in Cynomolgus Monkeys

Autor: David C. Ackley, Jason S. Isenberg, Arthur W. Lington, James E. Klaunig, Ray Brown, Jacqueline H. Smith, Lisa M. Kamendulis, Lisa J. Clare, George Pugh

Publikováno v: Toxicological Sciences. 56:181-188

The effects of the peroxisome proliferators di-isononyl phthalate (DINP) and di-2-ethylhexyl phthalate (DEHP) were evaluated in young adult male cynomolgus monkeys after 14 days of treatment, with emphasis on detecting hepatic and other effects seen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe586f2965391290d48f79e4b7b9b5be
https://doi.org/10.1093/toxsci/56.1.181

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Comparative in Vivo Hepatic Effects of Di-Isononyl Phthalate (DINP) and Related C7-C11 Dialkyl Phthalates on Gap Junctional Intercellular Communication (GJIC), Peroxisomal Beta-Oxidation (PBOX), and DNA Synthesis in Rat and Mouse Liver

Autor: David C. Ackley, Arthur W. Lington, Lisa M. Kamendulis, Jacqueline H. Smith, James E. Klaunig, Jason S. Isenberg, George Pugh

Publikováno v: Toxicological Sciences. 54:312-321

The short-term hepatic effects of DINP (CAS 68515-48-0, designated DINP-1) in rats and mice were evaluated at tumorigenic and nontumorigenic doses from previous chronic studies. Groups of male F344 rats were fed diets with DINP-1 at concentrations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58844a1e32a9dd5f1ef91ba8e5836958
https://doi.org/10.1093/toxsci/54.2.312

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The distribution of aluminum into and out of the brain

Autor: Robert A. Yokel, David D. Allen, David C Ackley

Publikováno v: Journal of Inorganic Biochemistry. 76:127-132

The extent, rate and possible mechanism(s) by which aluminum enters and is removed from the brain are presented. Introduction of Al into systemic circulation as Al.transferrin, the predominant Al species in plasma, resulted in about 7 x 10(-5) of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619284fe219b8efeb974a8fbc3238f9b
https://doi.org/10.1016/s0162-0134(99)00124-5

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Postmortem elevation in extracellular glutamate in the rat hippocampus when brain temperature is maintained at physiological levels: implications for the use of human brain autopsy tissues

Autor: Nada G Chang, Robert A. Yokel, Joseph P. McGillis, David C Ackley, James W. Geddes, Natalie S Soultanian

Publikováno v: Brain Research. 831:104-112

Postmortem alterations in the neuronal cytoskeleton resemble some aspects of the cytoskeletal disruption associated with neurodegenerative disorders, and are also similar to those observed following ischemia and produced by excitotoxins in vivo and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cbc43ebcb748a1c3e6f5f0a3c01d24
https://doi.org/10.1016/s0006-8993(99)01403-1

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Aluminum transport out of brain extracellular fluid is proton dependent and inhibited by mersalyl acid, suggesting mediation by the monocarboxylate transporter (MCT1)

Autor: David C Ackley, Robert A. Yokel

Publikováno v: Toxicology. 127:59-67

Blood–brain barrier transport of aluminum citrate was assessed in rats by microdialysis of the jugular vein as well as the right and left frontal cortices. Previous studies (Allen et al., 1995. Evidence for energy-dependent transport of aluminum ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b27b201d3b7bd73bef30e46a06687bf
https://doi.org/10.1016/s0300-483x(98)00037-7

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Aluminum citrate is transported from brain into blood via the monocar☐ylic acid transporter located at the blood-brain barrier

Autor: Robert A. Yokel, David C Ackley

Publikováno v: Toxicology. 120:89-97

Aluminum citrate transport across the blood-brain barrier was assessed in rats by in vivo microdialysis. Microdialysis probes were implanted in the jugular vein as well as the left and right frontal cortex. It was demonstrated previously (Allen et al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8e2c01c87e63c0dd2b62e9db5d9fbb
https://doi.org/10.1016/s0300-483x(97)03640-8

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Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics

Autor: Sarah J Crowell, Magee Thomas Victor, Jiri Aubrecht, Deborah A. Burt, David C. Ackley

Publikováno v: Drug and chemical toxicology. 37(2)

Polypeptide antibiotics, such as polymyxins and aminoglycosides, are essential for treatment of life-threatening Gram-negative infections. Acute kidney injury (AKI) attributed to treatment with these agents severely limits their clinical application.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63189d6677f4017eacd1b4d87c31dfc
https://pubmed.ncbi.nlm.nih.gov/24128070

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