Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David C Platt"'
Publikováno v:
Biology, Vol 12, Iss 4, p 537 (2023)
There is limited research on the association between the extracellular matrix (ECM) and chronic neuropathic pain. The objective of this study was twofold. Firstly, we aimed to assess changes in expression levels and the phosphorylation of ECM-related
Externí odkaz:
https://doaj.org/article/7ebd2c7d2ba249248d424d17af933985
Publikováno v:
Brain Sciences, Vol 12, Iss 11, p 1504 (2022)
This research focused on the development of an astrocyte cell model system (C6 glioma) for the assessment of molecular changes in response to cathodic passively balanced pulsed electrical stimulation at a rate of 50 Hz (60 µs duration, 0.15 mA inten
Externí odkaz:
https://doaj.org/article/09a5d59ee4054dda9308bd580f6ad1d2
Publikováno v:
Heliyon, Vol 7, Iss 9, Pp e07896- (2021)
Novel therapeutics for the treatment of leishmaniasis are of interest as the disease not only is becoming more prevalent, but drug resistance is increasing in certain regions of the world. Reported here is the use of Bi3+-doped strontium aluminum oxy
Externí odkaz:
https://doaj.org/article/a0a2d56f6dc8491981845164e69d7a63
Autor:
David L. Cedeño, Ricardo Vallejo, Courtney A. Kelley, David C. Platt, Leonid M. Litvak, Małgorzata Straka, David A. Dinsmoor
Publikováno v:
Neuromodulation: Technology at the Neural Interface. 26:68-77
Rats are commonly used for translational pain and spinal cord stimulation (SCS) research. Although many SCS parameters are configured identically between rats and humans, stimulation amplitudes in rats are often programmed relative to visual motor th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2627f7c26dcccd775c3d81ac9bf28fe4
https://doi.org/10.1016/j.neurom.2022.06.006
https://doi.org/10.1016/j.neurom.2022.06.006
Publikováno v:
Journal of Pain Research. 15:2857-2866
Spinal cord stimulation (SCS) has been used for decades to treat neuropathic pain conditions with limited understanding of its mechanisms of action. The mTOR pathway is a well-known co-factor in chronic pain and has not been previously linked to SCS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65df976715b578d4e353553f03286b86
https://doi.org/10.2147/jpr.s378490
https://doi.org/10.2147/jpr.s378490
Publikováno v:
Brain Sciences, Vol 11, Iss 5, p 588 (2021)
The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely. Recently, there has been renewed interest in the
Externí odkaz:
https://doaj.org/article/8d80a0acd9cc4ce8949b0b5e3eddb552
Autor:
Sarita Singh, Jacob P. Grabowski, Shilpa Pohani, C. Fiore Apuzzo, David C. Platt, Marjorie A. Jones, T. Andrew Mitchell
Publikováno v:
Molecules, Vol 25, Iss 22, p 5461 (2020)
Construction of a focused library of polycyclic ether-benzopyrans was undertaken in order to discover new therapeutic compounds that affect Leishmania growth and infectivity. This is especially of interest since there are few drug therapies for leish
Externí odkaz:
https://doaj.org/article/8bc3ca7971904e0db3edcafb773f4877
Autor:
Ricardo Vallejo, David C. Platt, Jonathan A. Rink, Marjorie A. Jones, Courtney A. Kelley, Ashim Gupta, Cynthia L. Cass, Kirk Eichenberg, Alejandro Vallejo, William J. Smith, Ramsin Benyamin, David L. Cedeño
Publikováno v:
Brain Sciences, Vol 9, Iss 11, p 303 (2019)
Glial cells comprise the majority of cells in the central nervous system and exhibit diverse functions including the development of persistent neuropathic pain. While earlier theories have proposed that the applied electric field specifically affects
Externí odkaz:
https://doaj.org/article/a14234ce35464e51821e7f948181b31a
Autor:
Marjorie A. Jones, David C. Platt, Samantha E. Huffman, Paige J. Bothwell, Samuel S. Fisher, Michael I. Webb, Gideon K. Yawson, Christopher G. Hamaker
Publikováno v:
Metallomics. 12:491-503
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ). These deposits contain a high concentration of metals and init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e25af24dfcf19e605c684f89164853
https://doi.org/10.1039/d0mt00054j
https://doi.org/10.1039/d0mt00054j
Autor:
Gideon K. Yawson, Mark F. Will, Samantha E. Huffman, Evan T. Strandquist, Paige J. Bothwell, Ethan B. Oliver, C. Fiore Apuzzo, David C. Platt, Christopher S. Weitzel, Marjorie A. Jones, Gregory M. Ferrence, Christopher G. Hamaker, Michael I. Webb
Publikováno v:
Inorganic chemistry. 61(6)
Alzheimer's disease (AD) is a devastating neurological disorder for which soluble oligomers of the peptide amyloid-β (Aβ) are now recognized as the neurotoxic species. Metal-based therapeutics are uniquely suited to target Aβ, with ruthenium-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1362f0c5c0ca11851c98002368aae43
https://pubmed.ncbi.nlm.nih.gov/35102739
https://pubmed.ncbi.nlm.nih.gov/35102739