Zobrazeno 1 - 10
of 119
pro vyhledávání: '"David C Lyon"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Traumatic brain injury is often followed by changes in neural connectivity. This study describes how inputs to a population of inhibitory neurons change to favor local over long-range connectivity in a mouse model of traumatic brain injury.
Externí odkaz:
https://doaj.org/article/2ca365a009774ae6a536a82b272970c0
Autor:
Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang, Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Leber congenital amaurosis is caused by mutations in RPE65 and leads to retinal degeneration in children. Here, the authors show that in vivo base editing can prolong the survival of cone photoreceptors and rescue their function in a mouse model of t
Externí odkaz:
https://doaj.org/article/ffc071797e4f4fa694375352a34ae7c4
Autor:
Jan C. Frankowski, Andrzej T. Foik, Alexa Tierno, Jiana R. Machhor, David C. Lyon, Robert F. Hunt
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Jan Frankowski and Andrzej Foik et al. characterized neuroanatomical, electrophysiological, and functional deficits in the primary visual cortex of mice after traumatic brain injury (TBI). Their results suggest that TBI produces long-lasting impairme
Externí odkaz:
https://doaj.org/article/d0bb20f93ded46f2934af56ab0de9010
Autor:
Dominik Lewandowski, Andrzej T. Foik, Roman Smidak, Elliot H. Choi, Jianye Zhang, Thanh Hoang, Aleksander Tworak, Susie Suh, Henri Leinonen, Zhiqian Dong, Antonio F.M. Pinto, Emily Tom, Jennings Luu, Joan Lee, Xiuli Ma, Erhard Bieberich, Seth Blackshaw, Alan Saghatelian, David C. Lyon, Dorota Skowronska-Krawczyk, Marcin Tabaka, Krzysztof Palczewski
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa. Here, we show that the
Externí odkaz:
https://doaj.org/article/d6761896c71d4db8902de4c695125400
Autor:
Qianlan Xu, Cezary Rydz, Viet Anh Nguyen Huu, Lorena Rocha, Claudia Palomino La Torre, Irene Lee, William Cho, Mary Jabari, John Donello, David C. Lyon, Robert T. Brooke, Steve Horvath, Robert N. Weinreb, Won‐Kyu Ju, Andrzej Foik, Dorota Skowronska‐Krawczyk
Publikováno v:
Aging Cell. 21
Aging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84abc5d08b0b41a8d50b98799b653d90
https://doi.org/10.1111/acel.13737
https://doi.org/10.1111/acel.13737
Autor:
Qianlan Xu, Cezary Rydz, Viet Anh Nguyen Huu, Lorena Rocha, Claudia Palomino La Torre, Irene Lee, William Cho, Mary Jabari, John Donello, Robert N. Weinreb, David C. Lyon, Won-Kyu Ju, Andrzej Foik, Dorota Skowronska-Krawczyk
Aging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecdc03542e0da0821be8ba289564b074
https://doi.org/10.1101/2022.05.01.490248
https://doi.org/10.1101/2022.05.01.490248
Publikováno v:
eNeuro, vol 9, iss 3
Inherited retinal degenerative diseases are a prominent cause of blindness. Even though mutations causing death of photoreceptors are mostly known, the pathophysiology downstream in the inner retina and along the visual pathway is incompletely charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f55c7b273d2620a19a2c1f5daf10a1
https://pubmed.ncbi.nlm.nih.gov/35701168
https://pubmed.ncbi.nlm.nih.gov/35701168
Autor:
David R. Liu, Elliot H. Choi, David C. Lyon, Krzysztof Palczewski, Philip D. Kiser, Zhiqian Dong, Gregory A. Newby, Wei-Hsi Yeh, Henri Leinonen, Andrzej T. Foik, Susie Suh
Publikováno v:
Nature Biomedical Engineering. 5:169-178
Cytosine base editors and adenine base editors (ABEs) can correct point mutations predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial indel formation) and homology-directed repair (which typically leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c683371459353d10dd9402c00b2c8b
https://doi.org/10.1038/s41551-020-00632-6
https://doi.org/10.1038/s41551-020-00632-6
Autor:
Robert F. Hunt, Alexa Tierno, Jan C. Frankowski, Andrzej T. Foik, Jiana R. Machhor, David C. Lyon
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications biology, vol 4, iss 1
Communications Biology
Communications biology, vol 4, iss 1
Primary sensory areas of the mammalian neocortex have a remarkable degree of plasticity, allowing neural circuits to adapt to dynamic environments. However, little is known about the effects of traumatic brain injury on visual circuit function. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe2350d023bfa854dcfb3a85d454a4b
https://doi.org/10.1038/s42003-021-02808-5
https://doi.org/10.1038/s42003-021-02808-5
Publikováno v:
Nature communications, vol 13, iss 1
Despite the fundamental importance of understanding the brain’s wiring diagram, our knowledge of how neuronal connectivity is rewired by traumatic brain injury remains remarkably incomplete. Here we use cellular resolution whole-brain imaging to ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9149868240e43420d8fb5832b59af438
https://pubmed.ncbi.nlm.nih.gov/35701434
https://pubmed.ncbi.nlm.nih.gov/35701434