Zobrazeno 1 - 10
of 123
pro vyhledávání: '"David C Lamb"'
Autor:
Djamal Brahim Belhaouari, Gabriel Augusto Pires De Souza, David C Lamb, Steven L Kelly, Jared V Goldstone, John J Stegeman, Philippe Colson, Bernard La Scola, Sarah Aherfi
Publikováno v:
eLife, Vol 11 (2022)
Viruses generally are defined as lacking the fundamental properties of living organisms in that they do not harbor an energy metabolism system or protein synthesis machinery. However, the discovery of giant viruses of amoeba has fundamentally challen
Externí odkaz:
https://doaj.org/article/b09784e9d64b4b65bdc673a3866ba9c5
Autor:
K. Garrett Evensen, Emily Rusin, William E. Robinson, Claire L. Price, Steven L. Kelly, David C. Lamb, Jared V. Goldstone, Helen C. Poynton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Mollusks are the second most diverse animal phylum, yet little is known about their endocrinology or how they respond to endocrine disrupting compound (EDC) pollution. Characteristic effects of endocrine disruption are reproductive impairmen
Externí odkaz:
https://doaj.org/article/b78008cc15074e3fadd038d1a669768e
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4886 (2024)
Cytochrome P450 CYP121A1 is a well-known drug target against Mycobacterium tuberculosis, the human pathogen that causes the deadly disease tuberculosis (TB). CYP121A1 is a unique P450 enzyme because it uses classical and non-classical P450 catalytic
Externí odkaz:
https://doaj.org/article/5cd2a85af10a4e119541f3844f04026f
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1733 (2023)
Cytochrome P450 monooxygenases (CYPs; P450s) are a superfamily of heme-containing enzymes that are recognized for their vast substrate range and oxidative multifunctionality. CYP107 family members perform hydroxylation and epoxidation processes, prod
Externí odkaz:
https://doaj.org/article/88c050ed11fb463e92faa5c4bf0e6428
Autor:
Nadja R. Brun, Matthew C. Salanga, Francisco X. Mora-Zamorano, David C. Lamb, Jared V. Goldstone, John J. Stegeman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Orphan cytochrome P450 (CYP) enzymes are those for which biological substrates and function(s) are unknown. Cytochrome P450 20A1 (CYP20A1) is the last human orphan P450 enzyme, and orthologs occur as single genes in every vertebrate genome s
Externí odkaz:
https://doaj.org/article/ceb380bb0c7d430288fcea9b53a2db9f
Autor:
Eric Chabrière, David C. Lamb, Didier Raoult, Sarah Aherfi, Anthony Levasseur, Bernard La Scola, Lucile Pinault, Jônatas Santos Abrahão, Jean-Pierre Baudoin, Philippe Colson, Djamal Brahim Belhaouari, Philippe Decloquement
Publikováno v:
ISME Journal
ISME Journal, Nature Publishing Group, 2021, ⟨10.1038/s41396-021-01117-3⟩
ISME Journal, 2022, 16 (3), pp.695-704. ⟨10.1038/s41396-021-01117-3⟩
ISME Journal, Nature Publishing Group, 2021, ⟨10.1038/s41396-021-01117-3⟩
ISME Journal, 2022, 16 (3), pp.695-704. ⟨10.1038/s41396-021-01117-3⟩
The discovery of Acanthamoeba polyphaga Mimivirus, the first isolated giant virus of amoeba, challenged the historical hallmarks defining a virus. Giant virion sizes are known to reach up to 2.3 µm, making them visible by optical microscopy. Their l
Autor:
Tatiana Y. Hargrove, David C. Lamb, Jarrod A. Smith, Zdzislaw Wawrzak, Steven L. Kelly, Galina I. Lepesheva
Publikováno v:
Scientific reports. 12(1)
The molecular evolution of cytochromes P450 and associated redox-driven oxidative catalysis remains a mystery in biology. It is widely believed that sterol 14α-demethylase (CYP51), an essential enzyme of sterol biosynthesis, is the ancestor of the w
Autor:
David C. Lamb, Jared V. Goldstone, Bin Zhao, Li Lei, Jonathan G. L. Mullins, Michael J. Allen, Steven L. Kelly, John J. Stegeman
Publikováno v:
Biomolecules; Volume 12; Issue 8; Pages: 1107
Flavodoxins are small electron transport proteins that are involved in a myriad of photosynthetic and non-photosynthetic metabolic pathways in Bacteria (including cyanobacteria), Archaea and some algae. The sequenced genome of 0305φ8-36, a large bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc9073629a16d32d66d2d954e139f1b
https://cronfa.swan.ac.uk/Record/cronfa62081/Download/62081__26030__f79a912a039444e69fbdc923d91af87f.pdf
https://cronfa.swan.ac.uk/Record/cronfa62081/Download/62081__26030__f79a912a039444e69fbdc923d91af87f.pdf
Autor:
Bin Zhao, Suzy C. Moody, Robert C. Hider, Li Lei, Steven L. Kelly, Michael R. Waterman, David C. Lamb
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 8500-8513 (2012)
Coelibactin is a putative non-ribosomally synthesized peptide with predicted zincophore activity and which has been implicated in antibiotic regulation in Streptomyces coelicolor A3(2). The coelibactin biosynthetic pathway contains a stereo- and regi
Externí odkaz:
https://doaj.org/article/921de6703eec453a9ad7f095c42b5ee5
Autor:
Francisco X. Mora-Zamorano, John J. Stegeman, Jared V. Goldstone, Matthew C. Salanga, David C. Lamb, Nadja R. Brun
Orphan cytochrome P450 (CYP) enzymes are those for which biological substrates and function(s) are unknown. Cytochrome P450 20A1 (CYP20A1) is the last human orphan P450 enzyme, and orthologs occur as single genes in every vertebrate genome sequenced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0ffeee36f0f7aeb0504a1256a04dc5
https://doi.org/10.1101/2021.07.23.453406
https://doi.org/10.1101/2021.07.23.453406