Mathematical modelling of oxygen gradients in stem cell-derived liver tissue.

Autor: Joseph A Leedale, Baltasar Lucendo-Villarin, Jose Meseguer-Ripolles, Alvile Kasarinaite, Steven D Webb, David C Hay

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0244070 (2021)

A major bottleneck in the study of human liver physiology is the provision of stable liver tissue in sufficient quantity. As a result, current approaches to modelling human drug efficacy and toxicity rely heavily on immortalized human and animal cell

Externí odkaz: https://doaj.org/article/f606f79e86c84e768d428358c04cb832

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

Autor: Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expressi

Externí odkaz: https://doaj.org/article/47d15d12bd9c4154ade149ceeddbddb9

Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

Autor: Sheng Yuan, Huipu Yuan, David C. Hay, Huan Hu, Chaochen Wang

Publikováno v: Biosensors, Vol 14, Iss 9, p 425 (2024)

Traditional drug development is a long and expensive process with high rates of failure. This has prompted the pharmaceutical industry to seek more efficient drug development frameworks, driving the emergence of organ-on-a-chip (OOC) based on microfl

Externí odkaz: https://doaj.org/article/75cec231f84a4df882a469a0e36ad3f4

The Influence of Sex Hormones in Liver Function and Disease

Autor: Alvile Kasarinaite, Matthew Sinton, Philippa T. K. Saunders, David C. Hay

Publikováno v: Cells, Vol 12, Iss 12, p 1604 (2023)

The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian liver physiology and the development of new model systems to improv

Externí odkaz: https://doaj.org/article/71480124054547bf98b11a651933734b

Chemically cross-linked hydrogels from repetitive protein arrays

Autor: Rossana Boni, Elizabeth A. Blackburn, Dirk-Jan Kleinjan, Mantas Jonaitis, Flora Hewitt-Harris, Megan Murdoch, Susan Rosser, David C. Hay, Lynne Regan

Publikováno v: Boni, R, Blackburn, E A, Kleinjan, D-J, Jonaitis, M, Hewitt-Harris, F, Murdoch, M, Rosser, S, Hay, D C & Regan, L 2023, ' Chemically cross-linked hydrogels from repetitive protein arrays ', Journal of Structural Biology, vol. 215, no. 3, 107981 . https://doi.org/10.1016/j.jsb.2023.107981

Biomaterials for tissue regeneration must mimic the biophysical properties of the native physiological environment. A protein engineering approach allows the generation of protein hydrogels with specific and customised biophysical properties designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d89f2afe8360d94a023840744057840
https://hdl.handle.net/20.500.11820/c3c93ba8-790d-41dc-b8e1-90f1faa0baa5