Zobrazeno 1 - 10
of 79
pro vyhledávání: '"David C Fargo"'
Autor:
Natalie Saini, Camille K Giacobone, Leszek J Klimczak, Brian N Papas, Adam B Burkholder, Jian-Liang Li, David C Fargo, Re Bai, Kevin Gerrish, Cynthia L Innes, Shepherd H Schurman, Dmitry A Gordenin
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009302 (2021)
Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication err
Externí odkaz:
https://doaj.org/article/512c8db43d254b92ad65696179c25e68
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007571 (2020)
High-throughput sequencing has become ubiquitous in biomedical sciences. As new technologies emerge and sequencing costs decline, the diversity and volume of available data increases exponentially, and successfully navigating the data becomes more ch
Externí odkaz:
https://doaj.org/article/00bc233056704ed390bb0a05354dff17
Autor:
Natalie Saini, Steven A Roberts, Leszek J Klimczak, Kin Chan, Sara A Grimm, Shuangshuang Dai, David C Fargo, Jayne C Boyer, William K Kaufmann, Jack A Taylor, Eunjung Lee, Isidro Cortes-Ciriano, Peter J Park, Shepherd H Schurman, Ewa P Malc, Piotr A Mieczkowski, Dmitry A Gordenin
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006385 (2016)
Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and impro
Externí odkaz:
https://doaj.org/article/148d642d05be4115befb367ef75ad6b5
Autor:
Christopher A Lavender, Kimberly R Cannady, Jackson A Hoffman, Kevin W Trotter, Daniel A Gilchrist, Brian D Bennett, Adam B Burkholder, Craig J Burd, David C Fargo, Trevor K Archer
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006224 (2016)
Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene
Externí odkaz:
https://doaj.org/article/2f0d439aff5d4fce89f99d8a68cb7f3b
Autor:
Tianyuan Wang, Janine H Santos, Jian Feng, David C Fargo, Li Shen, Gonzalo Riadi, Elizabeth Keeley, Zachary S Rosh, Eric J Nestler, Richard P Woychik
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159028 (2016)
Repetitive elements (REs) comprise 40-60% of the mammalian genome and have been shown to epigenetically influence the expression of genes through the formation of fusion transcript (FTs). We previously showed that an intracisternal A particle forms a
Externí odkaz:
https://doaj.org/article/15d56a31a03a4d48a3ac2c70ab092a7d
Autor:
Jasmine A. Mack, Adam Burkholder, Farida S. Akhtari, John S. House, Ulla Sovio, Gordon C.S. Smith, Charles P. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Publikováno v:
HGG Advances, Vol 6, Iss 1, Pp 100385- (2025)
Summary: Genetic factors related to pregnancy-related traits are understudied, especially in ancestrally diverse cohorts. To assess maternal contributions to hypertensive disorders of pregnancy (HDP), we performed a multi-ancestry genome-wide associa
Externí odkaz:
https://doaj.org/article/fe214fe7ea2846c3ac4af17ffeb4d26e
Autor:
Eunice Y. Lee, Wonson Choi, Adam B. Burkholder, Lalith Perera, Jasmine A. Mack, Frederick W. Miller, Michael B. Fessler, Donald N. Cook, Peer W. F. Karmaus, Hideki Nakano, Stavros Garantziotis, Jennifer H. Madenspacher, John S. House, Farida S. Akhtari, Charles S. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct genetic architecture associated w
Externí odkaz:
https://doaj.org/article/b4c25f7994204ed68ceec9b548045815
Autor:
Farida S. Akhtari, Dillon Lloyd, Adam Burkholder, Xiaoran Tong, John S. House, Eunice Y. Lee, John Buse, Shepherd H. Schurman, David C. Fargo, Charles P. Schmitt, Janet Hall, Alison A. Motsinger-Reif
OBJECTIVE Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the applicabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1466359c8d2c1393e7fddec02e40a4a
https://doi.org/10.2337/figshare.21399177.v1
https://doi.org/10.2337/figshare.21399177.v1
Autor:
Melissa E, Lowe, Farida S, Akhtari, Taylor A, Potter, David C, Fargo, Charles P, Schmitt, Shepherd H, Schurman, Kristin M, Eccles, Alison, Motsinger-Reif, Janet E, Hall, Kyle P, Messier
Publikováno v:
Journal of exposure scienceenvironmental epidemiology.
Autoimmune (AI) diseases appear to be a product of genetic predisposition and environmental triggers. Disruption of the skin barrier causes exacerbation of psoriasis/eczema. Oxidative stress is a mechanistic pathway for pathogenesis of the disease an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5a1e15cdabb4a47493aae6e72455756
https://pubmed.ncbi.nlm.nih.gov/36460922
https://pubmed.ncbi.nlm.nih.gov/36460922
Publikováno v:
Journal of Cell Science. 135
Cardiomyocyte elongation and alignment, a critical step in cardiomyocyte maturation starting from the perinatal stage, is crucial for formation of the highly organized intra- and inter-cellular structures for spatially and temporally ordered contract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bf86c1d2a263935dd603a213ce0797
https://doi.org/10.1242/jcs.259076
https://doi.org/10.1242/jcs.259076