High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer’s and Parkinson’s disease

Autor: David C. Emery, Maria Davies, Tanya L. Cerajewska, Jelena Taylor, Mae Hazell, Alex Paterson, Shelley J. Allen-Birt, Nicola X. West

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

IntroductionAlzheimer’s (AD) and Parkinson’s disease (PD) are neurodegenerative conditions characterized by incremental deposition of β-amyloid (Aβ) and α-synuclein in AD and PD brain, respectively, in relatively conserved patterns. Both are a

Externí odkaz: https://doaj.org/article/a7cd303dce9c44d7a90d409cec47a004

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

Autor: David C. Emery, Deborah K. Shoemark, Tom E. Batstone, Christy M. Waterfall, Jane A. Coghill, Tanya L. Cerajewska, Maria Davies, Nicola X. West, Shelley J. Allen

Publikováno v: Frontiers in Aging Neuroscience, Vol 9 (2017)

The neurological deterioration associated with Alzheimer’s disease (AD), involving accumulation of amyloid-beta peptides and neurofibrillary tangles, is associated with evident neuroinflammation. This is now seen to be a significant contributor to

Externí odkaz: https://doaj.org/article/3d2a064b980d4b818b14715f27d86fad

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

Autor: David C. Emery, David I. Marks, Aimie Norton, Claire M Rice, Martin G Guttridge, Neil J Scolding, Pamela Sarkar, Alastair Wilkins, Paul Virgo, Juliana Redondo, Joya Pawade, Kevin C Kemp

Publikováno v: Redondo, J, Sarkar, P, Kemp, K, Virgo, P F, Pawade, J, Norton, A, Emery, D C, Guttridge, M G, Marks, D I, Wilkins, A, Scolding, N J & Rice, C M 2018, ' Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro ', Multiple Sclerosis Journal, vol. 24, no. 7, pp. 919-931 . https://doi.org/10.1177/1352458517711276
Multiple Sclerosis (Houndmills, Basingstoke, England)

Background: Autologous bone-marrow-derived cells are currently employed in clinical studies of cell-based therapy in multiple sclerosis (MS) although the bone marrow microenvironment and marrow-derived cells isolated from patients with MS have not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12479caf14cb0c11ebebe21d80a3925e
https://doi.org/10.1177/1352458517711276

High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics

Autor: Michael P.S. Booth, Peter L. Roach, Martin R. Challand, David C. Emery, James Spencer

Publikováno v: Protein Expression and Purification. 74:204-210

Cfr is a radical-SAM ( S -adenosyl- l -methionine) enzyme that methylates the 8 position of 23S rRNA residue A2503 to confer resistance to multiple antibiotic classes acting upon the large subunit of the bacterial ribosome. Radical-SAM enzymes use an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9752e42eb22dcc5b616e00dc4ba38b71
https://doi.org/10.1016/j.pep.2010.07.010

Opportunities and Limits in Creating New Enzymes

Autor: DJ Halsall, Antoni Cortés, Anthony R. Clarke, J. John Holbrook, HM Wilks, David C. Emery

Publikováno v: Annals of the New York Academy of Sciences. 672:80-93

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7513c9e1720736ba20c36faae57dd0a4
https://doi.org/10.1111/j.1749-6632.1992.tb32662.x