Zobrazeno 1 - 10
of 130
pro vyhledávání: '"David C Crossman"'
Autor:
Svati H Shah, Neil J Freedman, Lisheng Zhang, David R Crosslin, David H Stone, Carol Haynes, Jessica Johnson, Sarah Nelson, Liyong Wang, Jessica J Connelly, Michael Muehlbauer, Geoffrey S Ginsburg, David C Crossman, Christopher J H Jones, Jeffery Vance, Michael H Sketch, Christopher B Granger, Christopher B Newgard, Simon G Gregory, Pascal J Goldschmidt-Clermont, William E Kraus, Elizabeth R Hauser
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000318 (2009)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, and functional analysis of
Externí odkaz:
https://doaj.org/article/088af6cb44d4434485213c7d62fcc9d7
Autor:
Janet Chamberlain, Sheila Francis, Zoe Brookes, Gary Shaw, Delyth Graham, Nicholas J Alp, Steven Dower, David C Crossman
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5073 (2009)
Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet. However, the interplay between diet, inflammatory mechanisms and vascular risk factors
Externí odkaz:
https://doaj.org/article/1b95793e04be4e09ba8137b926614ab3
Autor:
Jessica J Connelly, Tianyuan Wang, Julie E Cox, Carol Haynes, Liyong Wang, Svati H Shah, David R Crosslin, A Brent Hale, Sarah Nelson, David C Crossman, Christopher B Granger, Jonathan L Haines, Christopher J H Jones, Jeffery M Vance, Pascal J Goldschmidt-Clermont, William E Kraus, Elizabeth R Hauser, Simon G Gregory
Publikováno v:
PLoS Genetics, Vol 2, Iss 8, p e139 (2006)
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the aortic vasculature, namely aortic endothelial cells
Externí odkaz:
https://doaj.org/article/4ab45e6f573e4eb1b06d0f30bd8e2483
Publikováno v:
Journal of Thoracic Disease. 10:S3084-S3087
In the field of cardiovascular disease, the reporting of the Cantos trial was eagerly wait in 2017. It did not disappoint, and we have previously reviewed the cardiovascular implications of IL-1 beta inhibition in patients with cardiovascular risk, d
Publikováno v:
The Journal of Immunology. 200:1159-1168
Leukocytes sense extracellular ATP, a danger-associated molecular pattern, released during cellular stress and death, via activation of cell surface P2X and P2Y receptors. Here, we investigate P2 receptor expression in primary human monocyte-derived
Autor:
Patrick W. F. Hadoke, Alexander M.K. Rothman, Maria-Cruz Villa-Uriol, Sheila E. Francis, David C. Crossman, Junxi Wu, Janet Chamberlain, Torsten Schenkel, Mabruka Alfaidi, Paul C. Evans
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association
Alfaidi, M A, Chamberlain, J, Rothman, A, Crossman, D, Villa-Uriol, M-C, Hadoke, P, Wu, J, Schenkel, T, Evans, P C & Francis, S E 2018, ' Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL-1-Mediated Mechanism ', Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, vol. 7, no. 13 . https://doi.org/10.1161/JAHA.118.008757
Journal of the American Heart Association
Alfaidi, M A, Chamberlain, J, Rothman, A, Crossman, D, Villa-Uriol, M-C, Hadoke, P, Wu, J, Schenkel, T, Evans, P C & Francis, S E 2018, ' Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL-1-Mediated Mechanism ', Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, vol. 7, no. 13 . https://doi.org/10.1161/JAHA.118.008757
Background Hypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid ( DHA ) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established
When teaching clinical undergraduates about the cause of atherosclerosis the lecturer will highlight risk factors such as smoking, hypercholesterolaemia and hypertension that are mutable for therapeutic benefit. If the same lecturer were to be talkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d945ff19b434d41091257067295f76
https://europepmc.org/articles/PMC5756992/
https://europepmc.org/articles/PMC5756992/
Publikováno v:
Journal of Cell Science
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release. The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and m
Autor:
Nadine Arnold, Lan Zhao, Simon S. Cross, Janet Chamberlain, David G. Kiely, David C. Crossman, Lu Long, Nicholas W. Morrell, Claudia Paiva, Josephine A. Pickworth, Allan Lawrie, Sarah Dawson, Chris Newman, Sheila E. Francis, Abdul G. Hameed
Publikováno v:
The Journal of Experimental Medicine
Genetic deletion of TRAIL or antibody blockade prevents the development of pulmonary arterial hypertension and can reverse vascular remodeling in established disease.
Pulmonary arterial hypertension (PAH) is a life-threatening disease characteri
Pulmonary arterial hypertension (PAH) is a life-threatening disease characteri
Autor:
Adam Denes, Renaud Maroy, Christian Prenant, James C. Russell, Johann R. Selvarajah, Sharon Hulme, Pippa J. Tyrrell, Alexander Gerhard, Stuart M. Allan, Stephen J. Hopkins, Matthew Jones, Peter J Julyan, Karl Herholz, Rainer Hinz, Nancy J. Rothwell, Rachel Georgiou, David C. Crossman, Alison Smigova, Caroline Drake, Hervé Boutin, Gavin Brown, Barry W. McColl, Andy Vail, Michael Kassiou, Sheila E. Francis, Spencer D. Proctor
Publikováno v:
Brain, Behavior, and Immunity
Brain, Behavior, and Immunity; Vol 25
Drake, C, Boutin, H, Jones, M S, Denes, A, McColl, B W, Selvarajah, J R, Hulme, S, Georgiou, R F, Hinz, R, Gerhard, A, Vail, A, Prenant, C, Julyan, P, Maroy, R, Brown, G, Smigova, A, Herholz, K, Kassiou, M, Crossman, D, Francis, S, Proctor, S D, Russell, J C, Hopkins, S J, Tyrrell, P J, Rothwell, N J & Allan, S M 2011, ' Brain inflammation is induced by co-morbidities and risk factors for stroke ', Brain, Behavior, and Immunity, vol. 25, no. 6, pp. 1113-1122 . < http://www.sciencedirect.com/science/article/pii/S0889159111000584 >
Brain, Behavior, and Immunity; Vol 25
Drake, C, Boutin, H, Jones, M S, Denes, A, McColl, B W, Selvarajah, J R, Hulme, S, Georgiou, R F, Hinz, R, Gerhard, A, Vail, A, Prenant, C, Julyan, P, Maroy, R, Brown, G, Smigova, A, Herholz, K, Kassiou, M, Crossman, D, Francis, S, Proctor, S D, Russell, J C, Hopkins, S J, Tyrrell, P J, Rothwell, N J & Allan, S M 2011, ' Brain inflammation is induced by co-morbidities and risk factors for stroke ', Brain, Behavior, and Immunity, vol. 25, no. 6, pp. 1113-1122 . < http://www.sciencedirect.com/science/article/pii/S0889159111000584 >
Highlights ► Risk factors for stroke include atherosclerosis, obesity, diabetes and hypertension. ► Stroke risk factors are associated with peripheral inflammation. ► Corpulent rats and atherogenic mice show increased inflammation in the brain.