Zobrazeno 1 - 10
of 1 064
pro vyhledávání: '"David C, Whitcomb"'
Autor:
David C. Whitcomb, Sinead N. Duggan, Robert Martindale, Mark Lowe, Virginia A. Stallings, Darwin Conwell, Jodie A. Barkin, Georgios I. Papachristou, Sohail Z. Husain, Christopher E. Forsmark, Vivek Kaul
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 395-411 (2023)
Exocrine pancreatic insufficiency (EPI) is a clinically defined syndrome based on the physician’s assessment of a patient’s maldigestion. However, current clinical definitions are inadequate in determining (1) the threshold of reduced pancreatic
Externí odkaz:
https://doaj.org/article/b661e80b2dde44348d3261b79fd25db8
Autor:
Christian Bime, Nancy G. Casanova, Sara M. Camp, Radu C. Oita, Juliet Ndukum, Vivian Reyes Hernon, Dong Kyu Oh, Yansong Li, Phil J. Greer, David C. Whitcomb, Georgios I. Papachristou, Joe G. N. Garcia
Publikováno v:
BMC Anesthesiology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT) exhibits dual functionality – as an intracellular enzyme regulating nicotinamide adenine dinucleotide metabolism and as an extracellular secreted protein (eNAMPT) to function as a c
Externí odkaz:
https://doaj.org/article/4a9a6cb92cbb42b3867fe595c78e81c3
Autor:
David C. Whitcomb
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Traditional approaches to understanding the origins of chronic pancreatitis (CP) and find treatments led to abysmal failure. Thus, no drugs now exists to meet this need. Outdated concepts of the etiopathogenesis of CP have been replaced with new insi
Externí odkaz:
https://doaj.org/article/81d324cffa974e37ad61cc7d32e4bde0
Autor:
David C. Whitcomb
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 2, Pp 281-282 (2023)
Externí odkaz:
https://doaj.org/article/8f0fe4f1efce4dfa840c914abb135810
Autor:
Yonjung Kim, Ikhyun Jun, Dong Hoon Shin, Jihoon G. Yoon, He Piao, Jinsei Jung, Hyun Woo Park, Mary Hongying Cheng, Ivet Bahar, David C. Whitcomb, Min Goo Lee
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 79-103 (2020)
Backgraoud & Aims: Aberrant epithelial bicarbonate (HCO3−) secretion caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with several diseases including cystic fibrosis and pancreatitis. Dynamica
Externí odkaz:
https://doaj.org/article/c6eb1ab64573444889221934c2ae218e
Autor:
Robert S. Rosenson, Daniel Gaudet, Christie M. Ballantyne, Seth J. Baum, Jean Bergeron, Erin E. Kershaw, Patrick M. Moriarty, Paolo Rubba, David C. Whitcomb, Poulabi Banerjee, Andrew Gewitz, Claudia Gonzaga-Jauregui, Jennifer McGinniss, Manish P. Ponda, Robert Pordy, Jian Zhao, Daniel J. Rader
Publikováno v:
Nature Medicine. 29:729-737
Severe hypertriglyceridemia (sHTG) is an established risk factor for acute pancreatitis. Current therapeutic approaches for sHTG are often insufficient to reduce triglycerides and prevent acute pancreatitis. This phase 2 trial (NCT03452228) evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f5cffe8051f443eca39b064bb26f9c
https://doi.org/10.1038/s41591-023-02222-w
https://doi.org/10.1038/s41591-023-02222-w
Development of a Clinical Prediction Model for Diabetes in Chronic Pancreatitis: The PREDICT3c Study
Autor:
Christie Jeon, Phil A. Hart, Liang Li, Yunlong Yang, Eleanor Chang, Melena D. Bellin, William E. Fisher, Evan L. Fogel, Christopher E. Forsmark, Walter G. Park, Stephen K. Van Den Eeden, Santhi Swaroop Vege, Jose Serrano, David C. Whitcomb, Dana K. Andersen, Darwin L. Conwell, Dhiraj Yadav, Mark O. Goodarzi
Publikováno v:
Diabetes Care. 46:46-55
OBJECTIVE Diabetes that arises from chronic pancreatitis (CP) is associated with increased morbidity and mortality. Methods to predict which patients with CP are at greatest risk for diabetes are urgently needed. We aimed to examine independent risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366e702c8b1456b993098c975e775933
https://doi.org/10.2337/dc22-1414
https://doi.org/10.2337/dc22-1414
Autor:
Phil A. Hart, Dana K. Andersen, Erica Lyons, Gregory A. Cote, Zobeida Cruz-Monserrate, Robert H. Dworkin, B. Joseph Elmunzer, Evan L. Fogel, Christopher E. Forsmark, Ian Gilron, Megan Golden, Aysegul Gozu, Lindsay McNair, Stephen J. Pandol, Emily R. Perito, Anna Evans Phillips, Jennifer A. Rabbitts, David C. Whitcomb, John A. Windsor, Dhiraj Yadav, Tonya M. Palermo
Publikováno v:
Pancreas. 51(7)
Recurrent acute pancreatitis and chronic pancreatitis represent high morbidity diseases, which are frequently associated with chronic abdominal pain, pancreatic insufficiencies, and reduced quality of life. Currently, there are no therapies to revers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1a81f308f3157d69218e69ee609f41
https://pubmed.ncbi.nlm.nih.gov/36395394
https://pubmed.ncbi.nlm.nih.gov/36395394
Autor:
Jinhyuk Choi, Tae Gyu Oh, Hee-Won Jung, Kun-Young Park, Hyemi Shin, Taehee Jo, Du-Seock Kang, Dipanjan Chanda, Sujung Hong, Jina Kim, Hayoung Hwang, Moongi Ji, Minkyo Jung, Takashi Shoji, Ayami Matsushima, Pilhan Kim, Ji Young Mun, Man-Jeong Paik, Sung Jin Cho, In-Kyu Lee, David C. Whitcomb, Phil Greer, Brandon Blobner, Mark O. Goodarzi, Stephen J. Pandol, Jerome I. Rotter, Weiwei Fan, Sagar P. Bapat, Ye Zheng, Chris Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes, Eiji Yoshihara, Ronald M. Evans, Jae Myoung Suh
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Mitochondrial dysfunction disrupts the synthesis and secretion of digestive enzymes in pancreatic acinar cells and plays a primary role in the etiology of exocrine pancreas disorders. However, the transcriptional mechanisms that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757caf31c32fcca4a54d58e545d4d946
https://doi.org/10.1053/j.gastro.2022.04.013
https://doi.org/10.1053/j.gastro.2022.04.013
Autor:
David C. Whitcomb
Publikováno v:
Yamada's Atlas of Gastroenterology. :365-374
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8941b5533804b34a6a02026dea4f567
https://doi.org/10.1002/9781119600527.ch40
https://doi.org/10.1002/9781119600527.ch40