Zobrazeno 1 - 10
of 85
pro vyhledávání: '"David C, Swinney"'
Autor:
David C. Swinney, Jonathan A. Lee
Publikováno v:
F1000Research, Vol 9 (2020)
There is a great need for innovative new medicines to treat unmet medical needs. The discovery and development of innovative new medicines is extremely difficult, costly, and inefficient. In the last decade, phenotypic drug discovery (PDD) was reintr
Externí odkaz:
https://doaj.org/article/c848ebc131dc4c6a83b11656c0604dd3
Autor:
Corey A. Able, Richard A. Bond, Arvid Carlsson, V. Daniel Castracane, Annica Dahlström, Carl Djerassi, Roy O. Greep, Tomas G.M. Hökfelt, J.Th.A. Hurkmans, V. Craig Jordan, Taylor P. Kohn, David G. Lambert, Raj Makwana, Frederick Mitchelson, John Parascandola, Michael. J. Rand, Gareth J. Sanger, David C. Swinney, Marius Tausk, Rosalyn S. Yalow, Jacques M. van Rossum
Publikováno v:
Drug Action Haemodynamics and Immune Defence ISBN: 9780323855174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e2c8ad038e16dfe21e9554da6219de
https://doi.org/10.1016/b978-0-323-85517-4.00055-2
https://doi.org/10.1016/b978-0-323-85517-4.00055-2
Autor:
David C. Swinney
Publikováno v:
Drug Action Haemodynamics and Immune Defence ISBN: 9780323855174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57fc7702ba6bf504e14f5c2702ada42d
https://doi.org/10.1016/b978-0-323-85517-4.00009-6
https://doi.org/10.1016/b978-0-323-85517-4.00009-6
Autor:
Zachary T Swinney, Brad A Haubrich, Shuangluo Xia, Chakk Ramesha, Stephen R Gomez, Paul Guyett, Kojo Mensa-Wilmot, David C Swinney
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004506 (2016)
New therapeutics are needed for neglected tropical diseases including Human African trypanosomiasis (HAT), a progressive and fatal disease caused by the protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense. There is a need for simpl
Externí odkaz:
https://doaj.org/article/cd7c6b19e9004e11af64ca27cd9b44af
Autor:
Simon P Fletcher, Daniel J Chin, Lore Gruenbaum, Hans Bitter, Erik Rasmussen, Palanikumar Ravindran, David C Swinney, Fabian Birzele, Roland Schmucki, Stefan H Lorenz, Erhard Kopetzki, Jade Carter, Miriam Triyatni, Linta M Thampi, Junming Yang, Dalal AlDeghaither, Marta G Murreddu, Paul Cote, Stephan Menne
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005541 (2016)
Externí odkaz:
https://doaj.org/article/13b820dddb7745f69a4fca4a08965459
Autor:
Simon P Fletcher, Daniel J Chin, Lore Gruenbaum, Hans Bitter, Erik Rasmussen, Palanikumar Ravindran, David C Swinney, Fabian Birzele, Roland Schmucki, Stefan H Lorenz, Erhard Kopetzki, Jade Carter, Miriam Triyatni, Linta M Thampi, Junming Yang, Dalal AlDeghaither, Marta G Murreddu, Paul Cote, Stephan Menne
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005103 (2015)
Recombinant interferon-alpha (IFN-α) is an approved therapy for chronic hepatitis B (CHB), but the molecular basis of treatment response remains to be determined. The woodchuck model of chronic hepatitis B virus (HBV) infection displays many charact
Externí odkaz:
https://doaj.org/article/490241e2b789474f94c1b6547a08b2f4
Autor:
David C, Swinney
Publikováno v:
Pharmacology & Therapeutics. 238:108175
The interactions of candidate medicines with physiology that have yielded therapeutics are a small subset of the total interactions investigated. To be useful the interactions must initiate molecular actions that fix a disease phenotype. While much i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0037e3d901a24af89069db725d4a1a78
https://doi.org/10.1016/j.pharmthera.2022.108175
https://doi.org/10.1016/j.pharmthera.2022.108175
Autor:
Michael P. Pollastri, David C. Swinney
Publikováno v:
Neglected Tropical Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a59980a17f06b80abcea86fb6c090b
https://doi.org/10.1002/9783527808656.ch1
https://doi.org/10.1002/9783527808656.ch1
Publikováno v:
F1000Research, Vol 3 (2014)
Rare disease research has reached a tipping point, with the confluence of scientific and technologic developments that if appropriately harnessed, could lead to key breakthroughs and treatments for this set of devastating disorders. Industry-wide tre
Externí odkaz:
https://doaj.org/article/73be0e37484c41ef8a16ea06a61c7297
Autor:
David C Swinney
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Phenotypic assays are tools essential for drug discovery. Phenotypic assays have different types of endpoints depending on the goals; 1) empirical endpoints for basic research to understand the underlying biology that will lead to identification of t
Externí odkaz:
https://doaj.org/article/a8f058b2f9124a6995862ac2ca7f5a2e