Zobrazeno 1 - 10
of 417
pro vyhledávání: '"David C, Rubinsztein"'
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114872- (2024)
Summary: The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy. We identify a distinct nuclear interactome of TFEB, with ubiquitin-specific protease 7 (USP7) emerging as a key post-translational modulator of T
Externí odkaz:
https://doaj.org/article/352bb74afd544312b5ebdcdd93cf6990
Autor:
Roger A Barker, Laura Oakley, Emma Cutting, David C Rubinsztein, Dimitrios Apostolopoulos, Nikolaos Demiris, Katie Andresen, Amy H Evans, Alimu Dayimu, Katherine Bongaerts, Robyn Staples, Wendy Gooding
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Introduction Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder that presents with a progressive movement disorder along with cognitive and psychiatric problems. It is caused by a Cytosine-adenin-guanine (CAG) expansion i
Externí odkaz:
https://doaj.org/article/589e70e6f6874d20a47a4fc3a9577f30
Autor:
Lidia Wrobel, Sandra M. Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J. Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W. Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M. Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W. Bürli, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Several neurodegenerative diseases are characterized by the aggregation of cytoplasmic proteins. Here, the authors demonstrate that the small molecule SMER28 activates VCP, which enhances both autophagic and proteasomal clearance of aggregate-prone p
Externí odkaz:
https://doaj.org/article/02631720e7494834abf742bdf764ec8e
Autor:
Andrea Paolini, Saleh Omairi, Robert Mitchell, Danielle Vaughan, Antonios Matsakas, Sakthivel Vaiyapuri, Thomas Ricketts, David C. Rubinsztein, Ketan Patel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/3a43f4e03d724ff9822170a1b58196ae
Autor:
Angeleen Fleming, Low Zhe Xuan, Gentzane Sanchez-Elexpuru, Sarah V. Williams, Dylan Windell, Michael H. Gelb, Zackary M. Herbst, Lars Schlotawa, David C. Rubinsztein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Multiple sulfatase deficiency (MSD) is a rare recessively inherited Mendelian disorder that manifests with developmental delay, neurodegeneration, skeletal deformities, facial dysmorphism, congenital growth retardation, and other clinical signs. The
Externí odkaz:
https://doaj.org/article/2dd2afcac3604ef286f934e38bddb885
Autor:
Mariana Pavel, So Jung Park, Rebecca A. Frake, Sung Min Son, Marco M. Manni, Carla F. Bento, Maurizio Renna, Thomas Ricketts, Fiona M. Menzies, Radu Tanasa, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dy
Externí odkaz:
https://doaj.org/article/d02b9e5043ae49d9b06eb7b9936822b7
Autor:
Sung Min Son, So Jung Park, Eleanna Stamatakou, Mariella Vicinanza, Fiona M. Menzies, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Leucine is a critical amino acid that inhibits autophagy. Here, the authors show that the leucine inhibits autophagy in most cell types, predominantly via its catabolite acetyl CoA, which drives acetylation of raptor, which activates mTORC1, a negati
Externí odkaz:
https://doaj.org/article/629c1efbd3634ae6b0d6ad330b8f9c16
Autor:
Cansu Karabiyik, David C. Rubinsztein
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100926- (2021)
Summary: The regulation of lipid kinases has remained elusive given the difficulties of assessing changes in lipid levels. Here, we describe the isolation of protein and lipid kinases to determine the regulation of lipid kinases in vitro. This can be
Externí odkaz:
https://doaj.org/article/4527960ab75e43b4b6da0a09b35e445e
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100500- (2021)
Summary: We present a protocol for in vivo siRNA-mediated knockdown of a gene of interest in mouse liver using systemic delivery via intravenous injection. We describe a step-by-step protocol for delivery of siRNA particles, with tips on how to optim
Externí odkaz:
https://doaj.org/article/f55570cd21c347058b583f8a0474edb5
Autor:
Farah H. Siddiqi, Fiona M. Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D. Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J. R. Fernandes, Andrew Bassett, Eric Karran, Bruce L. Miller, Angeleen Fleming, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and c
Externí odkaz:
https://doaj.org/article/faadda18e0ed4177b4aba46493d7b981