Zobrazeno 1 - 10
of 411
pro vyhledávání: '"David C, Page"'
Autor:
Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100462- (2024)
Summary: Somatic cells of human males and females have 45 chromosomes in common, including the “active” X chromosome. In males the 46th chromosome is a Y; in females it is an “inactive” X (Xi). Through linear modeling of autosomal gene expres
Externí odkaz:
https://doaj.org/article/f7bcee4c14104a018d0e1ee125035ddd
Autor:
David C. Page
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100486- (2024)
We talk to David C. Page, corresponding author of “The human Y and inactive X chromosomes similarly modulate autosomal gene expression” in this issue of Cell Genomics, about his paper, the most exciting findings in the paper, and his advice for o
Externí odkaz:
https://doaj.org/article/1c3ec5f924bd466b8c89546ad01572c5
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/65080e1cc1504fe0b535f5efbbeadbc0
Autor:
Jennifer F. Hughes, Helen Skaletsky, Peter K. Nicholls, Alexis Drake, Tatyana Pyntikova, Ting-Jan Cho, Daniel W. Bellott, David C. Page
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now only recombine with each other within a short pseudoautosomal
Externí odkaz:
https://doaj.org/article/36f0d6bd4f974647b276c82792290331
Autor:
Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100259- (2023)
Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling re
Externí odkaz:
https://doaj.org/article/a25725f53e0c4b88aad1b61692c510c9
Autor:
Daniel W Bellott, Ting-Jan Cho, Emily K Jackson, Helen Skaletsky, Jennifer F Hughes, David C Page
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269692 (2022)
The reference sequence of structurally complex regions can only be obtained through a highly accurate clone-based approach that we call Single-Haplotype Iterative Mapping and Sequencing (SHIMS). In recent years, improvements to SHIMS have reduced the
Externí odkaz:
https://doaj.org/article/500048f345664927964d120462def086
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
AbstractGene conversion is GC-biased across a wide range of taxa. Large palindromes on mammalian sex chromosomes undergo frequent gene conversion that maintains arm-to-arm sequence identity greater than 99%, which may increase their susceptibility to
Externí odkaz:
https://doaj.org/article/5ec1cc3aad1746b5907296ee21e8baa5
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1481-1486 (2019)
The introduction of foreign DNA into cells and organisms has facilitated much of modern biological research, and it promises to become equally important in clinical practice. Locating sites of foreign DNA incorporation in mammalian genomes has proven
Externí odkaz:
https://doaj.org/article/2f2e57f8ab17474796dc5a12d42d188d
Autor:
Daniel Reichart, Gregory A. Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M. Gorham, Justin J. Curran, Aditya Raguram, Daniel M. DeLaughter, David A. Conner, Júlia D. C. Marsiglia, Sajeev Kohli, Lukas Chmatal, David C. Page, Nerea Zabaleta, Luk Vandenberghe, David R. Liu, Jonathan G. Seidman, Christine Seidman
Publikováno v:
Nature Medicine. 29:412-421
Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart failure and sudden cardiac death. In this study, we assessed two differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40c249da070ec355df913c8d97b81c9
https://doi.org/10.1038/s41591-022-02190-7
https://doi.org/10.1038/s41591-022-02190-7
Autor:
Maria M Mikedis, Yuting Fan, Peter K Nicholls, Tsutomu Endo, Emily K Jackson, Sarah A Cobb, Dirk G de Rooij, David C Page
Publikováno v:
eLife, Vol 9 (2020)
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined w
Externí odkaz:
https://doaj.org/article/2312dd28ddac47b695b92a14710794bd