Zobrazeno 1 - 10
of 296
pro vyhledávání: '"David C, Linehan"'
Autor:
Angela L. Hughson, Gary Hannon, Noah A. Salama, Tara G. Vrooman, Caroline A. Stockwell, Bradley N. Mills, Jesse Garrett-Larsen, Haoming Qiu, Roula Katerji, Lauren Benoodt, Carl J. Johnston, Joseph D. Murphy, Emma Kruger, Jian Ye, Nicholas W. Gavras, David C. Keeley, Shuyang S. Qin, Maggie L. Lesch, Jason B. Muhitch, Tanzy M.T. Love, Laura M. Calvi, Edith M. Lord, Nadia Luheshi, Jim Elyes, David C. Linehan, Scott A. Gerber
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102350- (2024)
Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fail due to th
Externí odkaz:
https://doaj.org/article/f027f2b3c534440cbdc1ca41fe01b771
Autor:
William B. Alexander, Wenjia Wang, Margaret A. Hill, Michael R. O'Dell, Luis I. Ruffolo, Bing Guo, Katherine M. Jackson, Nicholas Ullman, Scott C. Friedland, Matthew N. McCall, Ankit Patel, Nathania Figueroa-Guilliani, Mary Georger, Brian A. Belt, Christa L. Whitney-Miller, David C. Linehan, Patrick J. Murphy, Aram F. Hezel
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/7469cc9ebd474fc4b6eb1170fadc186d
Autor:
Taylor P. Uccello, Maggie L. Lesch, Sarah A. Kintzel, Lauren B. Gradzewicz, Lillia Lamrous, Shawn P. Murphy, Fergal J. Fleming, Bradley N. Mills, Joseph D. Murphy, Angela Hughson, Gary Hannon, Jesse Garrett-Larsen, Haoming Qiu, Michael G. Drage, Jian Ye, Nicholas W. Gavras, David C. Keeley, Tanzy M. T. Love, Elizabeth A. Repasky, Edith M. Lord, David C. Linehan, Scott A. Gerber
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-12 (2023)
Abstract Rectal cancer ranks as the second leading cause of cancer-related deaths. Neoadjuvant therapy for rectal cancer patients often results in individuals that respond well to therapy and those that respond poorly, requiring life-altering excisio
Externí odkaz:
https://doaj.org/article/e9b3abc8040b4f838d19d476c4b23ebc
Publikováno v:
European Journal of Pediatric Surgery Reports, Vol 12, Iss 01, Pp e58-e62 (2024)
Externí odkaz:
https://doaj.org/article/1d51b9f144b1480fb613aa8370d2bb89
Autor:
Jian Ye, Brian A Belt, David C Linehan, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Stereotactic body radiotherapy (SBRT) induces immunogenic cell death, leading to subsequent antitumor immune response that is in part counterbalanced by activation of immune evasive processes, for example, upregulation of programmed cell d
Externí odkaz:
https://doaj.org/article/df0812d98765426e92ae92d48cf997b7
Autor:
Jian Ye, Brian A Belt, Booyeon J Han, David C Linehan, Shuyang S Qin, Bradley N Mills, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen and damage-associated molecula
Externí odkaz:
https://doaj.org/article/54b3ed967a784f7b9badf62aea058989
Autor:
Taylor P. Uccello, MS, Sarah A. Kintzel, BS, Bradley N. Mills, PhD, Joseph D. Murphy, MS, Jesse Garrett-Larsen, BS, Nicholas G. Battaglia, PhD, Carlos J. Rodriguez, BS, Michael G. Drage, MD, Jian Ye, PhD, Tanzy M.T. Love, PhD, Carl J. Johnston, PhD, Elizabeth A. Repasky, PhD, Haoming Qiu, MD, David C. Linehan, MD, Edith M. Lord, PhD, Scott A. Gerber, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 2, Pp 100867- (2022)
Purpose: Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal tumors for radiation therapy (RT) without inducing systemic toxicity remains a barrier. We developed an innovativ
Externí odkaz:
https://doaj.org/article/e6a54b79ca5a4a35a5fb31b880e6b168
Autor:
Taylor P. Uccello, Maggie L. Lesch, Nicholas A. Ullman, Sarah A. Kintzel, Lauren B. Gradzewicz, Trishna Velagaleti, Fergal J. Fleming, Bradley N. Mills, Joseph D. Murphy, Jesse Garrett-Larsen, Haoming Qiu, Michael G. Drage, Jian Ye, Nicholas W. Gavras, Carl J. Johnston, Tanzy M.T. Love, Elizabeth A. Repasky, David C. Linehan, Edith M. Lord, Scott A. Gerber
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 115:733-745
Many solid tumors present with perineural invasion (PNI), and innervation correlates with worsened prognosis. The effects that commonly administered therapies such as radiation therapy (RT) have on PNI status remain unknown. We investigated the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b56771ec717c81948508072dea4336
https://doi.org/10.1016/j.ijrobp.2022.09.080
https://doi.org/10.1016/j.ijrobp.2022.09.080
Autor:
Alexa D. Melucci, Yatee A. Dave, Olivia F. Lynch, Shawn Hsu, Mariah R. Erlick, David C. Linehan, Jacob Moalem
Publikováno v:
The American Journal of Surgery. 225:206-211
Post-discharge opioid requirement after laparoscopic cholecystectomy (LC) is minimal, yet postoperative opioid prescriptions vary and opioid-free discharges are rare.Adult patients who underwent LC from 01/2019-12/2019 were reviewed. Univariate and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356a5d6c1a08b8d3c4914154203569e1
https://doi.org/10.1016/j.amjsurg.2022.07.027
https://doi.org/10.1016/j.amjsurg.2022.07.027
Autor:
Melissa A. Meyer, John M. Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, Cynthia Ma, Ryan C. Fields, David C. Linehan, Grant A. Challen, Roberta Faccio, Rebecca L. Aft, David G. DeNardo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs
Externí odkaz:
https://doaj.org/article/8ebabe15d49943d1834201842048ea26