Zobrazeno 1 - 10
of 79
pro vyhledávání: '"David C, Fargo"'
Autor:
Jasmine A. Mack, Adam Burkholder, Farida S. Akhtari, John S. House, Ulla Sovio, Gordon C.S. Smith, Charles P. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Publikováno v:
HGG Advances, Vol 6, Iss 1, Pp 100385- (2025)
Summary: Genetic factors related to pregnancy-related traits are understudied, especially in ancestrally diverse cohorts. To assess maternal contributions to hypertensive disorders of pregnancy (HDP), we performed a multi-ancestry genome-wide associa
Externí odkaz:
https://doaj.org/article/fe214fe7ea2846c3ac4af17ffeb4d26e
Autor:
Eunice Y. Lee, Wonson Choi, Adam B. Burkholder, Lalith Perera, Jasmine A. Mack, Frederick W. Miller, Michael B. Fessler, Donald N. Cook, Peer W. F. Karmaus, Hideki Nakano, Stavros Garantziotis, Jennifer H. Madenspacher, John S. House, Farida S. Akhtari, Charles S. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct genetic architecture associated w
Externí odkaz:
https://doaj.org/article/b4c25f7994204ed68ceec9b548045815
Autor:
Montserrat Ayala-Ramirez, Nathaniel MacNell, Lucy E. McNamee, John A. McGrath, Farida S. Akhtari, Matthew D. Curry, Askia K. Dunnon, Michael B. Fessler, Stavros Garantziotis, Christine G. Parks, David C. Fargo, Charles P. Schmitt, Alison A. Motsinger-Reif, Janet E. Hall, Frederick W. Miller, Shepherd H. Schurman
Publikováno v:
Environment International, Vol 171, Iss , Pp 107687- (2023)
Background: Concentrated animal feeding operations (CAFOs) are a source of environmental pollution and have been associated with a variety of health outcomes. Immune-mediated diseases (IMD) are characterized by dysregulation of the normal immune resp
Externí odkaz:
https://doaj.org/article/6fd750625d1e400ea420cb3e832fe69d
Autor:
Sara A. Grimm, Takashi Shimbo, Motoki Takaku, James W. Thomas, Scott Auerbach, Brian D. Bennett, John R. Bucher, Adam B. Burkholder, Frank Day, Ying Du, Christopher G. Duncan, John E. French, Julie F. Foley, Jianying Li, B. Alex Merrick, Raymond R. Tice, Tianyuan Wang, Xiaojiang Xu, NISC Comparative Sequencing Program, Pierre R. Bushel, David C. Fargo, James C. Mullikin, Paul A. Wade
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across g
Externí odkaz:
https://doaj.org/article/f487b8a5e96d4b4596531537eeed2656
Autor:
Natalie Saini, Camille K Giacobone, Leszek J Klimczak, Brian N Papas, Adam B Burkholder, Jian-Liang Li, David C Fargo, Re Bai, Kevin Gerrish, Cynthia L Innes, Shepherd H Schurman, Dmitry A Gordenin
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009302 (2021)
Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication err
Externí odkaz:
https://doaj.org/article/512c8db43d254b92ad65696179c25e68
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007571 (2020)
High-throughput sequencing has become ubiquitous in biomedical sciences. As new technologies emerge and sequencing costs decline, the diversity and volume of available data increases exponentially, and successfully navigating the data becomes more ch
Externí odkaz:
https://doaj.org/article/00bc233056704ed390bb0a05354dff17
Autor:
Adam B. Burkholder, Scott A. Lujan, Christopher A. Lavender, Sara A. Grimm, Thomas A. Kunkel, David C. Fargo
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background Identification of mutations from next-generation sequencing data typically requires a balance between sensitivity and accuracy. This is particularly true of DNA insertions and deletions (indels), that can impart significant phenot
Externí odkaz:
https://doaj.org/article/b4ed54e91cb7433e914d1cbea74bcdfe
Autor:
Xiaofeng Zheng, Pengyi Yang, Brad Lackford, Brian D. Bennett, Li Wang, Hui Li, Yu Wang, Yiliang Miao, Julie F. Foley, David C. Fargo, Ying Jin, Carmen J. Williams, Raja Jothi, Guang Hu
Publikováno v:
Stem Cell Reports, Vol 7, Iss 5, Pp 897-910 (2016)
Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation g
Externí odkaz:
https://doaj.org/article/5e00422cd03e49909d44be40876f4591
Autor:
Marti Borkent, Brian D. Bennett, Brad Lackford, Ori Bar-Nur, Justin Brumbaugh, Li Wang, Ying Du, David C. Fargo, Effie Apostolou, Sihem Cheloufi, Nimet Maherali, Stephen J. Elledge, Guang Hu, Konrad Hochedlinger
Publikováno v:
Stem Cell Reports, Vol 6, Iss 5, Pp 704-716 (2016)
The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced expression of OCT4, KLF4, SOX2, and C-MYC (OKSM) is slow and inefficient, suggesting that transcription factors have to overcome somatic barriers that
Externí odkaz:
https://doaj.org/article/b11125427b77433898ca63a05cc6349a
Autor:
Farida S. Akhtari, Dillon Lloyd, Adam Burkholder, Xiaoran Tong, John S. House, Eunice Y. Lee, John Buse, Shepherd H. Schurman, David C. Fargo, Charles P. Schmitt, Janet Hall, Alison A. Motsinger-Reif
OBJECTIVE Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the applicabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1466359c8d2c1393e7fddec02e40a4a
https://doi.org/10.2337/figshare.21399177.v1
https://doi.org/10.2337/figshare.21399177.v1
