Zobrazeno 1 - 10
of 77
pro vyhledávání: '"David Busseuil"'
Autor:
Maxime Meloche, Marc-Olivier Pilon, Sylvie Provost, Grégoire Leclair, Essaïd Oussaïd, Isabelle St-Jean, Martin Jutras, Marie-Josée Gaulin, Louis-Philippe Lemieux Perreault, Diane Valois, Ian Mongrain, David Busseuil, Jean-Lucien Rouleau, Jean-Claude Tardif, Marie-Pierre Dubé, Simon de Denus
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 6, p 649 (2024)
Cohort studies have identified several genetic determinants that could predict the clinical response to allopurinol. However, they have not been commonly used for genome-wide investigations to identify genetic determinants on allopurinol metabolism a
Externí odkaz:
https://doaj.org/article/28cfe486b33248c196cecc96d09710f3
Autor:
Jessica Hindi, Marc‐Olivier Pilon, Maxime Meloche, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 872-885 (2023)
Abstract Females present a higher risk of adverse drug reactions. Sex‐related differences in drug concentrations may contribute to these observations but they remain understudied given the underrepresentation of females in clinical trials. The aim
Externí odkaz:
https://doaj.org/article/58f822ad9b2840d0901676770757397e
Autor:
Sabrina Robert, Marc‐Olivier Pilon, Essaïd Oussaïd, Maxime Meloche, Grégoire Leclair, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Small studies suggest that amiodarone is a weak inhibitor of cytochrome P450 (CYP) 2D6. Inhibition of CYP2D6 leads to increases in concentrations of drugs metabolized by the enzyme, such as metoprolol. Considering that both metoprolol and am
Externí odkaz:
https://doaj.org/article/0853f8a5071a463ca8c6f9d55b6c7249
Autor:
Marc‐Olivier Pilon, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 2024-2034 (2022)
Abstract ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid
Externí odkaz:
https://doaj.org/article/f9425dbf0f014bcc896fcaa842b04bf7
Autor:
Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 1063-1073 (2022)
Abstract Large, observational genetic studies are commonly used to identify genetic factors associated with diseases and disease‐related traits. Such cohorts have not been commonly used to identify genetic predictors of drug dosing or concentration
Externí odkaz:
https://doaj.org/article/81b54697e31d490090a5d831aea25000
Autor:
François Roubille, Nolwenn Merlet, David Busseuil, Marine Ferron, Yanfen Shi, Teodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Daniel Rivas, Mariève Cossette, Marie-Claude Guertin, Eric Rhéaume, Jean-Claude Tardif
Publikováno v:
Atherosclerosis Plus, Vol 45, Iss , Pp 1-9 (2021)
Background and aims: The anti-inflammatory agent colchicine is gaining interest as a treatment for coronary artery disease. However, the effects of colchicine in atherosclerotic animal models are mostly unknown. This study aimed to evaluate colchicin
Externí odkaz:
https://doaj.org/article/4f77011ad4b64b2595504fd26a40faa1
Autor:
Marie-Pierre Dubé, Audrey Lemaçon, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Essaïd Oussaïd, Géraldine Asselin, Sylvie Provost, Maxine Sun, Johanna Sandoval, Marc-André Legault, Ian Mongrain, Anick Dubois, Diane Valois, Emma Dedelis, Jennifer Lousky, Julie Choi, Elisabeth Goulet, Christiane Savard, Lea-Mei Chicoine, Mariève Cossette, Malorie Chabot-Blanchet, Marie-Claude Guertin, Simon de Denus, Nadia Bouabdallaoui, Richard Marchand, Zohar Bassevitch, Anna Nozza, Daniel Gaudet, Philippe L. L’Allier, Julie Hussin, Guy Boivin, David Busseuil, Jean-Claude Tardif
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs
Externí odkaz:
https://doaj.org/article/22ad144ba1304827b38809d5ea8a9606
Autor:
Louisia Starnino, Gilles Dupuis, Lambert Busque, Vincent Bourgoin, Marie-Pierre Dubé, David Busseuil, Bianca D’Antono
Publikováno v:
Biology of Sex Differences, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Shorter telomere length (TL) may indicate premature cellular aging and increased risk for disease. While there is substantial evidence for shorter TL in individuals suffering from psychiatric disorders, data is scarce on maladapti
Externí odkaz:
https://doaj.org/article/dc3e9e308aa94601bd8f92071f5e3aca
Autor:
Simon deDenus, Fannie Mottet, Sandra Korol, Yassamin Feroz Zada, Sylvie Provost, Ian Mongrain, Géraldine Asselin, Essaïd Oussaïd, David Busseuil, Guillaume Lettre, John Rioux, Normand Racine, Eileen O'Meara, Michel White, Jean Rouleau, Jean Claude Tardif, Marie‐Pierre Dubé
Publikováno v:
ESC Heart Failure, Vol 7, Iss 6, Pp 4384-4389 (2020)
Abstract Aims Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups. Methods and resu
Externí odkaz:
https://doaj.org/article/3d6e05a5bc794595a3acaeab71ce9ed8
Autor:
Samuel Fleury, Mireille E. Schnitzer, Lawrence Ledoux-Hutchinson, Imane Boukhatem, Jean-Christophe Bélanger, Mélanie Welman, David Busseuil, Jean-Claude Tardif, Bianca D’Antono, Marie Lordkipanidzé
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological di
Externí odkaz:
https://doaj.org/article/dbd5860dd80c44b2b04b49de690cf44f