Zobrazeno 1 - 3
of 3
pro vyhledávání: '"David Buffet"'
Autor:
Thomas Hoyler, Bettina Bannert, Cédric André, Damian Beck, Thomas Boulay, David Buffet, Nadja Caesar, Thomas Calzascia, Janet Dawson, Diego Kyburz, Robert Hennze, Christine Huppertz, Amanda Littlewood-Evans, Pius Loetscher, Kirsten D. Mertz, Satoru Niwa, Gautier Robert, James S. Rush, Giulia Ruzzante, Sophie Sarret, Thomas Stein, Ismahane Touil, Grazyna Wieczorek, Geraldine Zipfel, Stuart Hawtin, Tobias Junt
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To study its functional role in joint inflammatio
Externí odkaz:
https://doaj.org/article/6fc6e2c6d008483f99d660e2370be0ce
Autor:
Tao Jiang, Stuart Hawtin, Claudia Betschart, Tobias Junt, Pierre-Yves Michellys, Maureen Ibanez, Satoru Niwa, Jillian Maginnis, Zhang Yi, Geraldine Collignon Zipfel, James S. Rush, Wendy Richmond, Daniel Mutnick, Perry Gordon, Bishnu P. Nayak, David Buffet, Xue-Feng Zhu, Bo Liu, Thomas Knoepfel, Phil B. Alper, Una McKeever, Jonathan A. Deane, Syka Peter, Janice Hampton
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Antagonism of the Toll-like receptors (TLRs) 7 and TLR8 has been hypothesized to be beneficial to patients suffering from autoimmune conditions. A phenotypic screen for small molecule antagonists of TLR7/8 was carried out in a murine P4H1 cell line.
Autor:
Tobias Junt, Grozdan Cvijetic, Laura Israel, Marc Bigaud, Yeter Kolb, Kea Martin, Ratiba Touil, David Buffet, Kathy D. McCoy, Satoru Niwa, Fernanda do Valle Duraes, Philip Smith, Anton Glück, Thomas Calzascia, Natasa Zamurovic, Pamela S. Ohashi, Kiichi Murakami, Frédéric Bornancin
The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of multiple receptors in both immune and nonimmune cells. Genetic disruption of Malt1 protease function in mice and MALT1 mutations in humans results in reduced regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70218121d58886c94f205754d3ff346
https://europepmc.org/articles/PMC6859376/
https://europepmc.org/articles/PMC6859376/