Zobrazeno 1 - 10
of 172
pro vyhledávání: '"David Bryder"'
Autor:
Sophia Engelhard, Montserrat Estruch, Shuyu Qin, Christoph A. Engelhard, Francisco G. Rodriguez-Gonzalez, Martine Drilsvik, Javier Martin-Gonzalez, Jeng-Wei Lu, David Bryder, Claus Nerlov, Joachim Weischenfeldt, Kristian Reckzeh, Kim Theilgaard-Mönch
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114475- (2024)
Summary: Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+ long-term repopulating HSCs (LT-HSCs; CD150+CD48−LSK) have a higher long-term multi-lin
Externí odkaz:
https://doaj.org/article/3dfc405563e042acaabd1378d8d20651
Publikováno v:
eLife, Vol 12 (2024)
The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After 3 weeks of culture, on
Externí odkaz:
https://doaj.org/article/3905155e244846d08981cb4fe022f738
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
Autor:
Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerbäck, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Böiers, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113357- (2023)
Externí odkaz:
https://doaj.org/article/afa99b9a000946b79b1053681bd6ceed
Autor:
Sudip Ghosh, Maria Jassinskaja, Mina Davoudi, Melina Claesson Stern, Ugarit Daher, Mohamed Eldeeb, David Bryder, Jenny Hansson
Publikováno v:
HemaSphere, Vol 7, p e932515d (2023)
Externí odkaz:
https://doaj.org/article/f2600bb5110e49daa9babecdafdc2c10
Autor:
Anna Konturek-Ciesla, Parashar Dhapola, Qinyu Zhang, Petter Säwén, Haixia Wan, Göran Karlsson, David Bryder
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112304- (2023)
Summary: Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure.
Externí odkaz:
https://doaj.org/article/16e2103f62f84a6d9818638bcd2db14c
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106341- (2023)
Summary: While tumor necrosis factor (TNF) is a critical mediator of appropriate immune response and tissue repair, its misregulation is linked to cancer, autoimmunity, bone marrow failure, and aging. Understanding the context-dependent roles of TNF
Externí odkaz:
https://doaj.org/article/ae4c568a225d4a4ea9c940aa064c414b
Autor:
Mohamed Eldeeb, Ouyang Yuan, Nicola Guzzi, Phuong Cao Thi Ngoc, Anna Konturek-Ciesla, Trine A. Kristiansen, Sowndarya Muthukumar, Jeffrey Magee, Cristian Bellodi, Joan Yuan, David Bryder
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112099- (2023)
Summary: MLL-rearrangements (MLL-r) are recurrent genetic events in acute myeloid leukemia (AML) and frequently associate with poor prognosis. In infants, MLL-r can be sufficient to drive transformation. However, despite the prenatal origin of MLL-r
Externí odkaz:
https://doaj.org/article/11caa6fa37dc4e3b9665a0f94329e489
Autor:
Anna Konturek-Ciesla, David Bryder
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
An appropriate production of mature blood cells, or hematopoiesis, is essential for organismal health and homeostasis. In this developmental cascade, hematopoietic stem cells (HSCs) differentiate into intermediate progenitor types, that subsequently
Externí odkaz:
https://doaj.org/article/3ad3e0695bc14407b9e27d010b1a638b
Autor:
Samuel Alsén, Jakob Cervin, Yaxiong Deng, Louis Szeponik, Ulf Alexander Wenzel, Joakim Karlsson, Helena Cucak, Megan Livingston, David Bryder, Qianjin Lu, Bengt Johansson-Lindbom, Ulf Yrlid
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B cells interact with T follicular helper (Tfh) cells in germinal centers (GCs) to generate high-affinity antibodies. Much less is known about how cognate T–B-cell interactions influence Th cells that enter circulation and peripheral tissues. There
Externí odkaz:
https://doaj.org/article/4d799bf2f9044fdbb729db3bcd5cb042
Autor:
Weiwei Yang, G. Devon Trahan, Elizabeth D. Howell, Nancy A. Speck, Kenneth L. Jones, Austin E. Gillen, Kent Riemondy, Jay Hesselberth, David Bryder, Patricia Ernst
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 285-299 (2020)
Summary: The Mixed Lineage Leukemia (MLL1, KMT2A) gene is critical for development and maintenance of hematopoietic stem cells (HSCs), however, whether this protein is limiting for HSC development is unknown due to lack of physiologic model systems.
Externí odkaz:
https://doaj.org/article/c35d9c3f1bf54f7e9b5d1d519b33cb62