Zobrazeno 1 - 10
of 49
pro vyhledávání: '"David Brian Camp"'
Publikováno v:
Journal of Natural Products. 78:1370-1382
The impact of time, therapy area, and route of administration on 13 physicochemical properties calculated for 664 drugs developed from a natural prototype was investigated. The mean values for the majority of properties sampled over five periods from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c440be17006421e5ecb051982b1a79e
https://doi.org/10.1021/acs.jnatprod.5b00255
https://doi.org/10.1021/acs.jnatprod.5b00255
Publikováno v:
Tetrahedron. 71:3932-3938
The rate of the Mitsunobu esterification reaction of ethanol or isopropanol with benzoic acid was found to be much faster in non-polar solvents. The logarithm of the rate constant was inversely proportional to the solvent polarity, as defined by ET v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d54c937eb9f325fd353624c1dd26ed15
https://doi.org/10.1016/j.tet.2015.04.035
https://doi.org/10.1016/j.tet.2015.04.035
Publikováno v:
Tetrahedron. 71:4946-4948
Previous DFT calculations employing phosphine (PH 3 ) and dimethyl azodicarboxylate showed that a cyclic O , N -phosphorane was energetically favored relative to betaine formation. In this study strong experimental support for the formation of the ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55378d9e17ccbe0d37937bf81cdfc704
https://doi.org/10.1016/j.tet.2015.05.099
https://doi.org/10.1016/j.tet.2015.05.099
Autor:
Lidija Jovanovic, Paul Baron, Lekha Suraweera, Juliette E Neve, David Brian Camp, Colleen C. Nelson, Ann Lam, Rohan A. Davis, John Lai
Publikováno v:
Magnetic Resonance in Chemistry. 51:358-363
A focused library based on the marine natural products polyandrocarpamines A (1) and B (2) has been designed and synthesised using parallel solution-phase chemistry. In silico physicochemical property calculations were performed on synthetic candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33af6fb521f37c8fcf1f6635a9e17d29
https://doi.org/10.1002/mrc.3958
https://doi.org/10.1002/mrc.3958
Publikováno v:
Journal of the American Chemical Society. 134:16188-16196
Treatment of triphenylphosphine (Ph(3)P) with an excess of diisopropyl azodicarboxylate at 0-25 °C resulted in the formation of a symmetrical tetraalkyl tetrazetidinetetracarboxylate radical cation, containing the elusive cyclic N(4) ring system. El
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b7e60f303345f0c392da2868af79c3
https://doi.org/10.1021/ja303019y
https://doi.org/10.1021/ja303019y
Autor:
William N. Charman, Ronald J. Quinn, Rohan A. Davis, Malcolm Stewart Buchanan, Vicky M. Avery, Susan A. Charman, Sandra Duffy, Karen L. White, Katherine T. Andrews, David Brian Camp, Michael D. Edstein, David M. Shackleford
Publikováno v:
Journal of Medicinal Chemistry. 55:5851-5858
A new bispyrroloiminoquinone alkaloid, tsitsikammamine C (1), displayed potent in vitro antimalarial activity with IC(50) values of 13 and 18 nM against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8383f059d18569ce7dea4f99550f5d44
https://doi.org/10.1021/jm3002795
https://doi.org/10.1021/jm3002795
Autor:
Ronald J. Quinn, Todd Shelper, Min Xu, David Brian Camp, Yunjiang Feng, Vicky M. Avery, Melissa Sykes, Rohan A. Davis
Publikováno v:
Journal of Natural Products. 75:1001-1005
A high-throughput screening campaign using a prefractionated natural product library and an in vitro Pseudomonas aeruginosa (PAO200 strain) assay identified two antibacterial fractions derived from the marine sponge Suberea ianthelliformis. Mass-dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af1737382adcd2f3745ca3bff4e422e
https://doi.org/10.1021/np300147d
https://doi.org/10.1021/np300147d
Publikováno v:
Journal of Natural Products. 75:72-81
While natural products or their derivatives and mimics have contributed around 50% of current drugs, there has been no approach allowing front-loading of chemical space compliant with lead- and drug-like properties. The importance of physicochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707a90d52c671442c778028e0bfbe984
https://doi.org/10.1021/np200687v
https://doi.org/10.1021/np200687v
Publikováno v:
Structural Chemistry. 21:1117-1129
This review introduces the Structural Chemistry Program at Griffith University’s Eskitis Institute, and provides a brief overview over its current and future research portfolio. Capitalising on the co-location with the Queensland Compound Library (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c380d884594b272e6d765d929e75e5
https://doi.org/10.1007/s11224-010-9654-2
https://doi.org/10.1007/s11224-010-9654-2
Autor:
Sheng Yin, Rohan A. Davis, David Brian Camp, Ronald J. Quinn, Vicky M. Avery, Melissa Sykes, Todd Shelper
Publikováno v:
Planta Medica. 76:1877-1881
Bioassay-guided fractionation of the CH(2)Cl(2)/MeOH extract from the Australian plant Glochidion sumatranum resulted in the isolation of four new galloylated flavanonols, (2R,3R)-dihydromyricetin-4'-O-(3''-O-methyl)-gallate (1), (2R,3R)-dihydromyric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34dc11ede801c575128acc3d1cadeef
https://doi.org/10.1055/s-0030-1250071
https://doi.org/10.1055/s-0030-1250071