Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David Brawand"'
Autor:
Mohammad Al-Agil, Stephen J. Obee, Vlad Dinu, James Teo, David Brawand, Piers E. M. Patten, Anwar Alhaq
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The aim is to develop and deploy an automated clinical alert system to enhance patient care and streamline healthcare operations. Structured and unstructured data from multiple sources are used to generate near real-time alerts fo
Externí odkaz:
https://doaj.org/article/13dd321dbf1742438b64ec7a180e59b8
Autor:
Michael Keane, Jeremy Semeiks, Andrew E. Webb, Yang I. Li, Víctor Quesada, Thomas Craig, Lone Bruhn Madsen, Sipko van Dam, David Brawand, Patrícia I. Marques, Pawel Michalak, Lin Kang, Jong Bhak, Hyung-Soon Yim, Nick V. Grishin, Nynne Hjort Nielsen, Mads Peter Heide-Jørgensen, Elias M. Oziolor, Cole W. Matson, George M. Church, Gary W. Stuart, John C. Patton, J. Craig George, Robert Suydam, Knud Larsen, Carlos López-Otín, Mary J. O’Connell, John W. Bickham, Bo Thomsen, João Pedro de Magalhães
Publikováno v:
Cell Reports, Vol 10, Iss 1, Pp 112-122 (2015)
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report
Externí odkaz:
https://doaj.org/article/5cb71fcc599b4343858c3cc10a216423
Autor:
Magali Soumillon, Anamaria Necsulea, Manuela Weier, David Brawand, Xiaolan Zhang, Hongcang Gu, Pauline Barthès, Maria Kokkinaki, Serge Nef, Andreas Gnirke, Martin Dym, Bernard de Massy, Tarjei S. Mikkelsen, Henrik Kaessmann
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2179-2190 (2013)
Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research. However, detailed genome-wide investigations of transcriptome complexity in major mammalian organs have been scarce. Here, using ex
Externí odkaz:
https://doaj.org/article/3b97df133e8f4989a02efd975a6ac3af
Autor:
Philippe Julien, David Brawand, Magali Soumillon, Anamaria Necsulea, Angélica Liechti, Frédéric Schütz, Tasman Daish, Frank Grützner, Henrik Kaessmann
Publikováno v:
PLoS Biology, Vol 10, Iss 5, p e1001328 (2012)
As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transc
Externí odkaz:
https://doaj.org/article/007f994e7b2f422da2a2f5367fe104bc
Autor:
Vincent Croset, Raphael Rytz, Scott F Cummins, Aidan Budd, David Brawand, Henrik Kaessmann, Toby J Gibson, Richard Benton
Publikováno v:
PLoS Genetics, Vol 6, Iss 8, p e1001064 (2010)
Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which are best characterized for their roles in synaptic communication in vertebrate nervous systems. A varia
Externí odkaz:
https://doaj.org/article/baaaa62f75c241a5908c684e5e70f85d
Publikováno v:
PLoS Biology, Vol 6, Iss 3, p e63 (2008)
Embryonic development in nonmammalian vertebrates depends entirely on nutritional reserves that are predominantly derived from vitellogenin proteins and stored in egg yolk. Mammals have evolved new resources, such as lactation and placentation, to no
Externí odkaz:
https://doaj.org/article/db7f2bae746c4116a55fd6bcde0fda4c
Publikováno v:
International Journal of Laboratory Hematology. 39:111-120
Introduction Next-generation sequencing (NGS), now embedded within genomic laboratories, is well suited to the detection of small sequence changes but is less well adapt for detecting structural variants (SV), mainly due to the relatively short seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bdb6e0d2d2103dc6362de4dc998978
https://doi.org/10.1111/ijlh.12680
https://doi.org/10.1111/ijlh.12680
Autor:
Frank W. Albert, Ayinuer Aximu-Petri, Magali Soumillon, Sven Bergmann, Frank Grützner, Svante Pääbo, Ulrich Zeller, Gábor Csárdi, Manuela Weier, Rasmus Nielsen, Martin Kircher, Anamaria Necsulea, Philippe Julien, David Brawand, Angélica Liechti, Philipp Khaitovich, Patrick Harrigan, Henrik Kaessmann
Publikováno v:
Nature
Nature, Nature Publishing Group, 2011, 478 (7369), pp.343-348. ⟨10.1038/nature10532⟩
Nature, Nature Publishing Group, 2011, 478 (7369), pp.343-348. ⟨10.1038/nature10532⟩
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0b925dde56b2e984a271b69225a2bc
https://doi.org/10.1038/nature10532
https://doi.org/10.1038/nature10532
Autor:
Eva Moldes Beiro, Barnaby Clark, Laura Steedman, Judith C. W. Marsh, Shreyans Ghandi, Peter Rushton, Frances Smith, Rachel Mayhew, Nicholas Parkin, Ghulam J. Mufti, Alison Bybee, Antonio Pagliuca, Austin G. Kulasekararaj, David C. Rees, David Brawand, Sahar Mansour, Subarna Chakravorty
Publikováno v:
Blood. 132:3609-3609
The genetic diagnosis of inherited anaemias is an important aspect of the diagnostic pathway for patients with haematological disorders, allowing discrimination between conditions of overlapping phenotypes therefore enabling more effective clinical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47e359e69f447079b9255cd71870be26
https://doi.org/10.1182/blood-2018-99-118799
https://doi.org/10.1182/blood-2018-99-118799
Autor:
John F. Engelhardt, Robert E. Palermo, Samantha M. Wisely, M. Suresh, Marcia Lara, Nives Škunca, Scott R. Tyler, Matthew J. Thomas, Thibaut Hourlier, Adam Siepel, Aaron M. Berlin, Kerstin Lindblad-Toh, Jennifer Tisoncik-Go, Kevin Gori, Sarah Young, Jason Turner-Maier, Jean Chang, Michael G. Katze, Sara M. Kelly, Bronwen Aken, Bruce W. Birren, G. Lynn Law, David Brawand, Ross Swofford, Yoshihiro Kawaoka, Federica Di Palma, Amie J. Eisfeld, Terrence M. Tumpey, Jeremy Johnson, Jessica Alföldi, Christophe Dessimoz, David J. Gasper, Pamela Russell, Masato Hatta, Xingshen Sun, Yaling Yi, Steve Searle, Xinxia Peng
Publikováno v:
Nature Biotechnology, 32 (12)
Nature biotechnology
Nature biotechnology
The domestic ferret (Mustela putorius furo) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission. Here we describe the 2.41 Gb draft g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57e056ed3b149bbd8a8dd16525b0ff
https://hdl.handle.net/20.500.11850/94757
https://hdl.handle.net/20.500.11850/94757
