Zobrazeno 1 - 10
of 29
pro vyhledávání: '"David Bom"'
Autor:
Hyun Jung Kim, Matthew Julian, Calum Williams, David Bombara, Juejun Hu, Tian Gu, Kiumars Aryana, Godfrey Sauti, William Humphreys
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Recent growth in space systems has seen increasing capabilities packed into smaller and lighter Earth observation and deep space mission spacecraft. Phase-change materials (PCMs) are nonvolatile, reconfigurable, fast-switching, and have rece
Externí odkaz:
https://doaj.org/article/d339764c73ec42d68e2a3dbbee298453
Autor:
Philipp Knopf, Dimitri Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M. Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D. Pagel, Marieke F. Fransen, Martin Röcken, André F. Martins, Bernd J. Pichler, Kamran Ghoreschi, Manfred Kneilling
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L
Externí odkaz:
https://doaj.org/article/b3fa661fa2c8409a83b991ccda94efe7
Publikováno v:
Applied Sciences, Vol 14, Iss 18, p 8194 (2024)
This study investigated the microstructural constituents and forming properties of alloy Al-1.4 wt.% Fe with different additions of Ce and/or La. The addition of rare earth (RE) elements to aluminum alloys improves their microstructures in their as-c
Externí odkaz:
https://doaj.org/article/9c5f69fad08042609e9c1c7aca068ac6
Autor:
Tomer Meirson, Valerio Nardone, Francesca Pentimalli, Gal Markel, David Bomze, Maria D’Apolito, Pierpaolo Correale, Antonio Giordano, Luigi Pirtoli, Camillo Porta, Steven G Gray, Luciano Mutti
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-9 (2022)
Abstract In this commentary, using existing clinical trial data and FDA approvals we propose that there is currently a critical need for an appropriate balancing between the financial impact of new cancer drugs and their actual benefit for patients.
Externí odkaz:
https://doaj.org/article/31b55a1ccc204e26bbba66e8945e4d5e
Autor:
Hyun Jung Kim, Matthew Julian, Calum Williams, David Bombara, Juejun Hu, Tian Gu, Kiumars Aryana, Godfrey Sauti, William Humphreys
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/859e8ef3ff864ffaa4ce8890aeaa365b
Autor:
Thomas G. Burke, David Bom
Publikováno v:
Annals of the New York Academy of Sciences. 922:36-45
The camptothecins as a class have exhibited unique dynamics and reactivity in vivo, with respect to both drug hydrolysis and blood protein interactions. These factors have confounded their pharmaceutical development and clinical implementation. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094f8cb81e6b972a584241c8a28d9888
https://doi.org/10.1111/j.1749-6632.2000.tb07023.x
https://doi.org/10.1111/j.1749-6632.2000.tb07023.x
Autor:
Rodney Andrews, John P. Selegue, David Bom, Bailin Chen, David Jacques, John E. Anthony, Mark S. Meier
Publikováno v:
Nano Letters. 2:615-619
Thermogravimetric analysis (TGA) has demonstrated that multiwalled nanotubes (MWNTs) annealed at 2200 to 2800 °C are more air stable than as-produced MWNTs, diamond, graphite, and annealed diamond. The annealed MWNTs are similar in stability to anne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bb5605232ce243a367bdd072b9dd3f4
https://doi.org/10.1021/nl020297u
https://doi.org/10.1021/nl020297u
Autor:
David Bom, Thomas G. Burke, Robert L. Bevins, J. N. Howe, Stefan Kruszewski, Lori J. Latus, Stephen G. Zimmer, AL Bingcang, Junhong Zhang, Dennis P. Curran
Publikováno v:
Journal of Controlled Release. 74:325-333
The novel silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin (DB-67) is 25- to 50-times more lipophilic than camptothecin and readily incorporates into lipid bilayers. Using the method of fluorescence anisotropy titration, we determined that DB-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d818169135afd043418c7f4b0b2a25c5
https://doi.org/10.1016/s0168-3659(01)00343-1
https://doi.org/10.1016/s0168-3659(01)00343-1
Autor:
Kimberly A. Fraley, David Bom, Stephen G. Zimmer, Lori J. Latus, Stefan Kruszewski, Ashok J. Chavan, Thomas G. Burke, Dennis P. Curran, Wu Du, Glenda Kohlhagen, Yves Pommier, J. Thompson Strode, Alex L. Bingcang
Publikováno v:
Journal of Medicinal Chemistry. 43:3970-3980
We describe the rational design and synthesis of B- and A, B-ring-modified camptothecins. The key alpha-hydroxy-delta-lactone pharmacophore in 7-tert-butyldimethylsilyl-10-hydroxycamptothecin (DB-67, 14) displays superior stability in human blood whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02e889869eb11054d77d53d3468a763
https://doi.org/10.1021/jm000144o
https://doi.org/10.1021/jm000144o
Publikováno v:
Chemistry - A European Journal. 4:67-83
The power of radical reactions continues to increase! A cascade radical annulation route now allows perhaps the mildest and most general method for the synthesis of both known and new members of the camptothecin family (parent structure on the right)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ecd6f4132ff3a35f7efc7dcf50cbfd
https://doi.org/10.1002/(sici)1521-3765(199801)4:1<67::aid-chem67>3.0.co
https://doi.org/10.1002/(sici)1521-3765(199801)4:1<67::aid-chem67>3.0.co