Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Autor: Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Masumi Okuda, Takako Osaki, Shigeru Kamiya, Chaochen Wang, Kazuo Hara, Yasuhiro Shimizu, Tatsuo Miyamoto, Yuko Hayashi, Hiromichi Ebi, Tomohiro Kohmoto, Issei Imoto, Yumiko Kasugai, Yoshinori Murakami, Masato Akiyama, Kazuyoshi Ishigaki, Koichi Matsuda, Makoto Hirata, Kazuaki Shimada, Takuji Okusaka, Takahisa Kawaguchi, Meiko Takahashi, Yoshiyuki Watanabe, Kiyonori Kuriki, Aya Kadota, Rieko Okada, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Atsushi Goto, Kengo Kinoshita, Nobuo Fuse, Fumiki Katsuoka, Atsushi Shimizu, Satoshi S. Nishizuka, Kozo Tanno, Ken Suzuki, Yukinori Okada, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki, Herbert Yu, Jun Zhong, Laufey T. Amundadottir, Yuichiro Doki, Hideshi Ishii, Hidetoshi Eguchi, David Bogumil, Christopher A. Haiman, Loic Le Marchand, Masaki Mori, Harvey Risch, Veronica W. Setiawan, Shoichiro Tsugane, Kenji Wakai, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi, Keitaro Matsuo

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in population

Externí odkaz: https://doaj.org/article/0e3ece4078314ff691b9afbec5ed4300

Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study.

Autor: Samantha A Streicher, Unhee Lim, S Lani Park, Yuqing Li, Xin Sheng, Victor Hom, Lucy Xia, Loreall Pooler, John Shepherd, Lenora W M Loo, Burcu F Darst, Heather M Highland, Linda M Polfus, David Bogumil, Thomas Ernst, Steven Buchthal, Adrian A Franke, Veronica Wendy Setiawan, Maarit Tiirikainen, Lynne R Wilkens, Christopher A Haiman, Daniel O Stram, Iona Cheng, Loïc Le Marchand

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0249615 (2021)

Several studies have found associations between higher pancreatic fat content and adverse health outcomes, such as diabetes and the metabolic syndrome, but investigations into the genetic contributions to pancreatic fat are limited. This genome-wide

Externí odkaz: https://doaj.org/article/b361d70db41041cbb12d5be579e444fb

Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study

Autor: David Bogumil, Victoria K. Cortessis, Lynne R. Wilkens, Loïc Le Marchand, Christopher A. Haiman, Gertraud Maskarinec, Veronica Wendy Setiawan

Publikováno v: Cancer Research Communications. 3:755-762

Background: Research on the association between type 2 diabetes (T2D) and bladder cancer (BCA) risk among non-European ancestry populations is sparse to nonexistent, and most prior studies rely on a single baseline assessment of T2D status. Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9819f1b1cc157b55e43358f13a5812e9
https://doi.org/10.1158/2767-9764.crc-22-0288

TABLE 1 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study

Autor: Veronica Wendy Setiawan, Gertraud Maskarinec, Christopher A. Haiman, Loïc Le Marchand, Lynne R. Wilkens, Victoria K. Cortessis, David Bogumil

Cohort characteristics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c2e3eefc1787665130687a14392422
https://doi.org/10.1158/2767-9764.22732003.v1

FIGURE 2 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study

Autor: Veronica Wendy Setiawan, Gertraud Maskarinec, Christopher A. Haiman, Loïc Le Marchand, Lynne R. Wilkens, Victoria K. Cortessis, David Bogumil

Association between Any T2D and bladder cancer in the multiethnic sample stratified by sex, smoking status, alcohol consumption, and BMI. Models adjusted for pack-years smoked (0, 1–10, 11–20, 21–30, 31–40, >40), alcohol consumption (1 drinks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f68a7b7e3fe1818845be3ed4118e99
https://doi.org/10.1158/2767-9764.22732051.v1