Zobrazeno 1 - 10
of 44
pro vyhledávání: '"David Blocquel"'
Autor:
Sven Bervoets, Na Wei, Maria-Luise Erfurth, Shazie Yusein-Myashkova, Biljana Ermanoska, Ligia Mateiu, Bob Asselbergh, David Blocquel, Priyanka Kakad, Tyrone Penserga, Florian P Thomas, Velina Guergueltcheva, Ivailo Tournev, Tanja Godenschwege, Albena Jordanova, Xiang-Lei Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contribute
Externí odkaz:
https://doaj.org/article/21bb42563b3e4403b71172f684a5c1f1
Autor:
Huihao Zhou, Bernhard Kuhle, Jingjing Zhang, Zaneta Matuszek, Litao Sun, Rita Horvath, Paul Schimmel, David Blocquel, Tao Pan, Na Wei, Thomas Weber, Philippe Latour, Xiang-Lei Yang, Weiwei He, Patrick R. Griffin, Scott J. Novick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Charcot-Marie-Tooth disease (CMT) is a devastating motor and sensory neuropathy with an estimated 100,000 afflicted individuals in the US. Unexpectedly, aminoacyl-tRNA synthetases are the largest disease-associated protein family. A natu
Autor:
Edoardo Salladini, Yuko Fujioka, Marina Lotti, David Blocquel, Antoine Gruet, Noriyuki Kodera, Daisuke Noshiro, Nobuo N. Noda, Mineyuki Mizuguchi, Tetsuya Mori, Mamoru Sato, Marion Dosnon, Christophe Bignon, Takashi Oda, Sonia Longhi, Johnny Habchi, Sujit Kumar Dora, Toshio Ando
Publikováno v:
Nature Nanotechnology
Nature Nanotechnology, 2021, 16 (2), pp.181-189. ⟨10.1038/s41565-020-00798-9⟩
Nature Nanotechnology, Nature Publishing Group, 2021, 16 (2), pp.181-189. ⟨10.1038/s41565-020-00798-9⟩
Nature Nanotechnology, 2021, 16 (2), pp.181-189. ⟨10.1038/s41565-020-00798-9⟩
Nature Nanotechnology, Nature Publishing Group, 2021, 16 (2), pp.181-189. ⟨10.1038/s41565-020-00798-9⟩
International audience; High-speed AFM imaging enables a semiquantitative, realistic description of the dynamic structure of intrinsically disordered proteins.Intrinsically disordered proteins (IDPs) are ubiquitous proteins that are disordered entire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f5c66b7933600b9a34f968937c68cd
http://hdl.handle.net/10281/295727
http://hdl.handle.net/10281/295727
Autor:
David, Blocquel, Jean-Marie, Bourhis, Jean-François, Éléouët, Denis, Gerlier, Johnny, Habchi, Marc, Jamin, Sonia, Longhi, Filip, Yabukarski
Publikováno v:
Virologie (Montrouge, France). 16(4)
Viruses with a non-segmented negative-sense RNA genome, or Mononegavirales, are important pathogens for plants, animals and humans with major socio-economic and health impacts. Among them are well-known human pathogens such as measles, mumps and resp
Autor:
Guillaume Communie, Johnny Habchi, Filip Yabukarski, David Blocquel, Robert Schneider, Nicolas Tarbouriech, Nicolas Papageorgiou, Rob W H Ruigrok, Marc Jamin, Malene Ringkjøbing Jensen, Sonia Longhi, Martin Blackledge
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003631 (2013)
Hendra virus (HeV) is a recently emerged severe human pathogen that belongs to the Henipavirus genus within the Paramyxoviridae family. The HeV genome is encapsidated by the nucleoprotein (N) within a helical nucleocapsid. Recruitment of the viral po
Externí odkaz:
https://doaj.org/article/f545aa83c6b2468d878c9bf9a27c5149
Autor:
Herwin Daub, David Blocquel, Jiadong Zhou, Na Wei, Xiang-Lei Yang, Albena Jordanova, Maria-Luise Erfurth, Grace Kooi, Mathew Sajish, Ge Bai, Sheng Li, Paul Schimmel
Publikováno v:
Nucleic Acids Research
Nucleic acids research
Nucleic acids research
While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) disease suggests a common mechanism, a defect in enzymatic activity is not shared among the CMT-causing mutants. Protein misfolding is a common hypothesis underl
Autor:
Zaneta Matuszek, David Blocquel, Bernhard Kuhle, Litao Sun, Na Wei, Thomas Weber, Sheng Li, Xiang-Lei Yang, Grace Kooi, Jonathan Baets, Paul Schimmel, Tao Pan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) are the largest protein family causatively linked to neurodegenerative Charcot–Marie–Tooth (CMT) disease. Dominant mutations cause the disease, and studies of CMT disease-causing mutant glycyl-tRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544659d54080e02e0a0c1df1ac1780a6
https://europepmc.org/articles/PMC6765236/
https://europepmc.org/articles/PMC6765236/
Autor:
Albena Jordanova, David Blocquel, Derek Atkinson, Tinne Ooms, Thorsten Hornemann, Vedrana Milic Rasic, Xiang-Lei Yang, Biljana Ermanoska, Alejandro Estrada-Cuzcano, Regula Steiner, Jelena Nikodinovic Glumac, K. Peeters, Els De Vriendt, Bob Asselbergh
Publikováno v:
Neurology
Objective:To identify the unknown genetic cause in a nuclear family with an axonal form of peripheral neuropathy and atypical disease course.Methods:Detailed neurologic, electrophysiologic, and neuropathologic examinations of the patients were perfor
Autor:
David Blocquel, François Ferron, Johnny Habchi, Marion Sevajol, Eric Durand, Nicolas Papageorgiou, Sonia Longhi, Jenny Erales
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:1589-1603
The structures of two constructs of themeasles virus(MeV) phosphoprotein (P) multimerization domain (PMD) are reported and are compared with a third structure published recently by another group [Communieet al.(2013),J. Virol.87, 7166–7169]. Althou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(50)
The 20 aminoacyl tRNA synthetases (aaRSs) couple each amino acid to their cognate tRNAs. During evolution, 19 aaRSs expanded by acquiring novel noncatalytic appended domains, which are absent from bacteria and many lower eukaryotes but confer extrace