Physiologically-Based Pharmacokinetic Modeling and In Vitro–In Vivo Correlation of TV-46000 (Risperidone LAI): Prediction from Dog to Human

Autor: David Bibi, Raphael Bilgraer, Lilach Steiner, Hussein Hallak

Publikováno v: Pharmaceutics, Vol 16, Iss 7, p 896 (2024)

The interest in the development and therapeutic application of long-acting injectable products for chronic or long-term treatments has experienced exponential growth in recent decades. TV-46000 (Uzedy, Teva) is a long-acting subcutaneous (sc) injecta

Externí odkaz: https://doaj.org/article/e6298492b68d4b7592574b3b7f693b17

Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative

Autor: David Bibi, Bella Shusterman, Alessio Nocentini, Claudiu T. Supuran, Meir Bialer

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1078-1082 (2019)

3-Methylpentyl(4-sulphamoylphenyl)carbamate (MSPC) came as the most potent compound out of a new series of carbamates composed of phenyl-ethanol or branched aliphatic alcohols, and 4-benzenesulphonamide-carbamic acid. In this study, the anticonvulsan

Externí odkaz: https://doaj.org/article/92bcde199f7a4c4d8bddc75382e327ec

Comparative efficacy of valnoctamide and sec ‐butylpropylacetamide ( SPD ) in terminating nerve agent–induced seizures in pediatric rats

Autor: Liana M. Matson, Robyn B. Lee-Stubbs, Kari M. Haines, David Bibi, Cherish E. Ardinger, John H. McDonough, Emily N. Dunn, Meir Bialer

Publikováno v: Epilepsia. 60:315-321

Objectives Children and adults are likely to be among the casualties in a civilian nerve agent exposure. This study evaluated the efficacy of valnoctamide (racemic-VCD), sec-butylpropylacetamide (racemic-SPD), and phenobarbital for stopping nerve age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68842d5e07302a96fdd524e036965253
https://doi.org/10.1111/epi.14630

Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide

Autor: David Bibi, Hafiz Mawasi, Bogdan J. Wlodarczyk, Meir Bialer, Alessio Nocentini, Claudiu T. Supuran, Richard H. Finnell

Publikováno v: Neurochemical Research. 42:1972-1982

Epilepsy is one of the most common neurological diseases, with between 34 and 76 per 100,000 people developing epilepsy annually. Epilepsy therapy for the past 100+ years is based on the use of antiepileptic drugs (AEDs). Despite the availability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb58f8a68f5b65a79de37979647b3362
https://doi.org/10.1007/s11064-017-2216-x

Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative

Autor: Meir Bialer, Claudiu T. Supuran, Alessio Nocentini, David Bibi, Bella Shusterman

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1078-1082 (2019)

3-Methylpentyl(4-sulphamoylphenyl)carbamate (MSPC) came as the most potent compound out of a new series of carbamates composed of phenyl-ethanol or branched aliphatic alcohols, and 4-benzenesulphonamide-carbamic acid. In this study, the anticonvulsan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a6360671aa2b7ac7c57b124c3497f
https://pubmed.ncbi.nlm.nih.gov/31124389