Zobrazeno 1 - 10
of 91
pro vyhledávání: '"David Bhella"'
Autor:
Miriam Weckener, Laura S. Woodward, Bradley R. Clarke, Huanting Liu, Philip N. Ward, Audrey Le Bas, David Bhella, Chris Whitfield, James H. Naismith
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
The enterobacterial common antigen (ECA) is a carbohydrate polymer that is associated with the cell envelope in the Enterobacteriaceae. ECA contains a repeating trisaccharide which is polymerized by WzyE, a member of the Wzy membrane protein polymera
Externí odkaz:
https://doaj.org/article/19c5542dd1c9491aa5e65f1ae1097f02
Autor:
Eleni-Anna Loundras, James Streetley, Morgan R. Herod, Rebecca Thompson, Mark Harris, David Bhella, Nicola J. Stonehouse
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Loundras et al. report on the fibril components of the RNA-dependent RNA polymerase RdRp from foot-and-mouth disease virus. They demonstrate that higher-order fibril-based interactions create multiple complex structures within which RNA replication c
Externí odkaz:
https://doaj.org/article/fd0cabf965964352a52c576ea4715475
Autor:
Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C. Morgan, Wendy Beattie, Augusto C. Montezano, Brian Hudson, Andrew B. Tobin, David Bhella, Rhian M. Touyz, Andrew G. Jamieson, George S. Baillie, Connor M. Blair
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of
Externí odkaz:
https://doaj.org/article/f0f07f9a6ed44895934fa969a58c9b5e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract White tail disease in the giant freshwater prawn Macrobrachium rosenbergii causes significant economic losses in shrimp farms and hatcheries and poses a threat to food-security in many developing countries. Outbreaks of Macrobrachium rosenbe
Externí odkaz:
https://doaj.org/article/f953ba71eea14ac0baeed379a3717712
Autor:
Kok Lian Ho, Mads Gabrielsen, Poay Ling Beh, Chare Li Kueh, Qiu Xian Thong, James Streetley, Wen Siang Tan, David Bhella
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e3000038 (2018)
Macrobrachium rosenbergii nodavirus (MrNV) is a pathogen of freshwater prawns that poses a threat to food security and causes significant economic losses in the aquaculture industries of many developing nations. A detailed understanding of the MrNV v
Externí odkaz:
https://doaj.org/article/a6b0a234275a418db02ace10ea451fd0
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2006191 (2018)
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. Herpes virions contain a large icosahedral cap
Externí odkaz:
https://doaj.org/article/4a3c82e5d2a945dc8488fac0bf646a95
Autor:
Michal Barski, Benjamin Brennan, Ona K Miller, Jane A Potter, Swetha Vijayakrishnan, David Bhella, James H Naismith, Richard M Elliott, Ulrich Schwarz-Linek
Publikováno v:
eLife, Vol 6 (2017)
Rift Valley fever phlebovirus (RVFV) is a clinically and economically important pathogen increasingly likely to cause widespread epidemics. RVFV virulence depends on the interferon antagonist non-structural protein (NSs), which remains poorly charact
Externí odkaz:
https://doaj.org/article/19588a1c3b574d549ea54582638575ab
Autor:
Suzannah J Rihn, Sam J Wilson, Nick J Loman, Mudathir Alim, Saskia E Bakker, David Bhella, Robert J Gifford, Frazer J Rixon, Paul D Bieniasz
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003461 (2013)
Genetic robustness, or fragility, is defined as the ability, or lack thereof, of a biological entity to maintain function in the face of mutations. Viruses that replicate via RNA intermediates exhibit high mutation rates, and robustness should be par
Externí odkaz:
https://doaj.org/article/34a40bd4ec5d4f0b983759833986b91d
Autor:
Swetha Vijayakrishnan, Colin Loney, David Jackson, Worawit Suphamungmee, Frazer J Rixon, David Bhella
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003413 (2013)
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical. However,
Externí odkaz:
https://doaj.org/article/bae84438e99f489a9d68774a79135066
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002961 (2012)
Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learned about the structure of the genome packaging and release machinery in the capsids of these large and complex double-stranded DNA v
Externí odkaz:
https://doaj.org/article/66c75e64b98d44a4bcb7fcb1f05ba0b2